Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Fumiaki, Kojima"'
Autor:
Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikawa
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2200-2214 (2023)
Epidemiological studies have shown that abnormalities of glucose metabolism are involved in leucine‐rich repeat kinase 2 (LRRK2)‐associated Parkinson's disease (PD). However, the physiological significance of this association is unclear. In the p
Externí odkaz:
https://doaj.org/article/b45a9cfcdb4646e59fbb5d9ee09970be
Autor:
Fumiaki Kojima, Hiroki Sekiya, Yuka Hioki, Hitoshi Kashiwagi, Makoto Kubo, Masaki Nakamura, Shotaro Maehana, Yoshitaka Imamichi, Koh-ichi Yuhki, Fumitaka Ushikubi, Hidero Kitasato, Takafumi Ichikawa
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-24 (2022)
Abstract Background Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H2 to PGE2. The present study investigated the effect o
Externí odkaz:
https://doaj.org/article/78235e4fb4724385b2106c700040599e
Autor:
Go Kagiya, Ayaka Sato, Ryohei Ogawa, Masanori Hatashita, Mana Kato, Makoto Kubo, Fumiaki Kojima, Fumitaka Kawakami, Yukari Nishimura, Naoya Abe, Fuminori Hyodo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 48-58 (2021)
Necrosis, a form of cell death, occurs not only with the development of various diseases but also with a tumor tissue response to cancer treatment. Therefore, pursuing progress for cancer therapy through induction of necrosis may be one of the most e
Externí odkaz:
https://doaj.org/article/a8422860f1134a349d7729310fc023de
Autor:
Ryotaro Eda, Shotaro Maehana, Aki Hirabayashi, Masaki Nakamura, Takashi Furukawa, Shinsuke Ikeda, Kouji Sakai, Fumiaki Kojima, Kazunari Sei, Masato Suzuki, Hidero Kitasato
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 24, Iss , Pp 180-182 (2021)
Objectives: The Klebsiella pneumoniae carbapenemase (blaKPC) gene is one of the most widespread carbapenemase genes in the world. However, there are few reports on KPC-producing bacteria in Japan. The aim of this study was therefore to investigate KP
Externí odkaz:
https://doaj.org/article/090c4f68405740b78f1739ab9cf3e3bf
Autor:
Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Shun Tamaki, Rei Kawashima, Tatsunori Maekawa, Yoshifumi Kurosaki, Fumiaki Kojima, Takafumi Ichikawa
Epidemiological studies have shown that abnormalities of glucose metabolism are involved in leucine-rich repeat kinase 2 (LRRK2)-associated Parkinson's disease (PD). However, the physiological significance of this association is unclear. In the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f10bcaea7c4b00a5e57a49e1eb77089b
https://doi.org/10.21203/rs.3.rs-2184589/v1
https://doi.org/10.21203/rs.3.rs-2184589/v1
Autor:
Hitoshi Kashiwagi, Koh-ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa, Shuh Narumiya, Fumitaka Ushikubi
Publikováno v:
TH Open, Vol 01, Iss 02, Pp e122-e129 (2017)
The results of studies that were performed to determine whether cigarette smoking affects platelet function have been controversial, and the effects of nicotine- and tar-free cigarette smoke extract (CSE) on platelet function remain to be determined.
Externí odkaz:
https://doaj.org/article/fba1e4b6dccf43528bc4de002045df76
Autor:
Mana Kato, Fumitaka Kawakami, Fumiaki Kojima, Ryohei Ogawa, Fuminori Hyodo, Makoto Kubo, Naoya Abe, Masanori Hatashita, Yukari Nishimura, Ayaka Sato, Go Kagiya
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 48-58 (2021)
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 48-58 (2021)
Necrosis, a form of cell death, occurs not only with the development of various diseases but also with a tumor tissue response to cancer treatment. Therefore, pursuing progress for cancer therapy through induction of necrosis may be one of the most e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7560bad91e966d4c6a97182b747e53c
https://doi.org/10.1016/j.omto.2020.12.001
https://doi.org/10.1016/j.omto.2020.12.001
Autor:
Motoki Imai, Fumiaki Kojima, Rei Kawashima, Fumitaka Kawakami, Makoto Kanzaki, Takafumi Ichikawa, Hiroko Maruyama, Makoto Kubo, Yoshifumi Kurosaki, Tatsunori Maekawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1660-1668
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson's disease. LRRK2 is a large protein with multiple functional domains, including a guanosine 5'-triphosphate (GTP)-binding domain and a protein kinase domain. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819f9e8706d09e274b4b2c48135fd6e1
https://doi.org/10.1248/bpb.b20-00377
https://doi.org/10.1248/bpb.b20-00377
Autor:
Yoshitaka Morita, Yuki Kakio, Yoshiko Hada, Tomoyuki Mukai, Fumiaki Kojima, Nozomu Otaka, Hidemi Takeuchi, Masashi Yoshida, Jun Wada, Haruhito A. Uchida
Publikováno v:
Clinical Science. 134:2771-2787
The aim of the present study was to examine whether inhibition of Interleukin (IL)-6 signaling by MR16-1, an IL-6 receptor antibody, attenuates aortitis, cardiac hypertrophy, and arthritis in IL-1 receptor antagonist deficient (IL-1RA KO) mice. Four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af591b5552347dc3a296141a7f31b7b
https://doi.org/10.1042/cs20201036
https://doi.org/10.1042/cs20201036
Autor:
Aya Sato, Fumiaki Kojima, Toru Hayashi, Shiho Arichi, Yoshihiro Maruo, Hitoshi Ishibashi, Kei Eto
Publikováno v:
Pharmacological reports : PR. 74(4)
XE991 (10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone) is reportedly a potent and selective Kv7 (KCNQ) channel inhibitor. This study aimed to evaluate how XE991 affects nicotinic responses in intracardiac ganglion neurons.We studied how the KCNQ ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84167aac5d6ed4e7c9df3b2dad74786b
https://pubmed.ncbi.nlm.nih.gov/35672575
https://pubmed.ncbi.nlm.nih.gov/35672575