Výsledky vyhledávání - "Fumiaki, Kikuchi"

Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore

Publikováno v: Journal of Medicinal Chemistry. 65:4270-4290

Inhibition of glucosylceramide synthase (GCS) is a major therapeutic strategy for Gaucher's disease and has been suggested as a potential target for treating Parkinson's disease. Herein, we report the discovery of novel brain-penetrant GCS inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a407ff68d50cb206d4c182ef36b2c1cf
https://doi.org/10.1021/acs.jmedchem.1c02078

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Photoredox-based late-stage functionalization in SAR study for in vivo potent glucosylceramide synthase inhibitor

Autor: Junsi, Wang, Matthew, Reynolds, Ignacio, Ibáñez, Yusuke, Sasaki, Yuta, Tanaka, Fumiaki, Kikuchi, Tomohiro, Ohashi, Sho, Sato, Mariko, Miyabayashi, Takahiro, Fujii

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 77:129039

Glucosylceramide synthase (GCS) has drawn much attention as an attractive protein target in the disease pathways of Parkinson's Disease (PD) and lysosomal storage disorders, such as Gaucher's Disease (GD). In previous our study, T-036 and its analogu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e43699fcdad22e872a4f0e3c985b22
https://doi.org/10.1016/j.bmcl.2022.129039

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How Does the Likelihood of Categorization into Consideration Sets Decrease from the Brand Considered Most Frequently? Focusing on Think and Feel Product Classification

Autor: Fumiaki Kikuchi

Publikováno v: SSRN Electronic Journal.

This paper explores how the likelihood of categorization into a consideration set decreases from the top brand. In Study 1, based on the assumption that decreases in likelihood differ among product categories, we divided products into ‘think’ and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7217d39d485fba91a37dd53c16916e8d
https://doi.org/10.2139/ssrn.3068584

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The Influence of Consumers’ Logical and Affective Brand Evaluation Inclinations on Consideration Set Composition

Autor: Fumiaki Kikuchi

Publikováno v: Journal of Marketing Management and Consumer Behavior, Vol 1, Iss 3 (2016)

This paper explores how consumers’ brand evaluation inclinations influence the degree of brand convergence in their consideration sets. We treated consumers’ brand evaluation inclinations two-dimensionally (logical and affective) and divided cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73db5d4b5994d26a2211e1520c5b3fa4
https://journal-of-marketing-management-and-consumer-behavior.com/index.php/JMMCB/article/view/34

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Total Syntheses of (+)-Polygalolide A and (+)-Polygalolide B: Elucidation of the Absolute Stereochemistry and Biogenetic Implications

Autor: Akinori Toita, Shunichi Hashimoto, Fumiaki Kikuchi, Yukihito Sugano, Seiichi Nakamura

Publikováno v: Chemistry - A European Journal. 18:9682-9690

The total syntheses of (+)-polygalolide A and (+)-polygalolide B have been completed by using a carbonyl ylide cycloaddition strategy. Three of the four stereocenters, including two consecutive tetrasubstituted carbon atoms at C2 and C8, were incorpo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b089caea70f6ce85c195e3fa1f859c50
https://doi.org/10.1002/chem.201200542

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Stereoselective synthesis of a C1-C6 fragment of pinnatoxin A via a 1,4-addition/alkylation sequence

Autor: Shunichi Hashimoto, Fumiaki Kikuchi, Seiichi Nakamura

Publikováno v: Tetrahedron Asymmetry. 19(9):1059-1067

A C1–C6 fragment of pinnatoxin A, (5 S ,6 R )-5,6-dimethyl-3-methyleneoxepan-2-one, which features a γ,δ- trans -dimethyl-substituted α-methylene lactone, has been synthesized in an enantiomerically pure form from ethyl ( E )-4-benzyloxy-2-buten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6a09d6d003f66175c5f215e850a761
http://hdl.handle.net/2115/33049

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Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis

Autor: Akio Kihara, Shunichi Hashimoto, Fumiaki Kikuchi, Mika Ikeda, Chang-Hwan Choi, Yasuyuki Igarashi, Seiichi Nakamura, Yong-Moon Lee, Yuki Kariya

Publikováno v: Genes to Cells. 10:605-615

Sphingosine 1-phosphate (S1P) functions as a ligand for the S1P/EDG family receptors. For years, intracellular signaling roles for S1P have also been suggested, especially in cell proliferation. Now, we have generated several mouse F9 embryonic carci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01f819634ab5282124e780e96522bb10
https://doi.org/10.1111/j.1365-2443.2005.00862.x

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