Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Fumi Higuchi"'
Autor:
Yoshiaki Goto, Ai Kawaguchi, Yuki Inoue, Yuki Nakamura, Yuta Oyama, Arisa Tomioka, Fumi Higuchi, Takeshi Uno, Masaaki Shojima, Taichi Kin, Masahiro Shin
Publikováno v:
Cancers, Vol 15, Iss 7, p 2148 (2023)
In endoscopic transsphenoidal skull base surgery, knowledge of tumor location on imaging and the anatomic structures is required simultaneously. However, it is often difficult to accurately reconstruct the endoscopic vision of the surgical field from
Externí odkaz:
https://doaj.org/article/726e402d51c64b88a5f16f6c264e2a05
Autor:
Nakamasa Hayashi, Hideaki Takahashi, Yuzo Hasegawa, Fumi Higuchi, Masamichi Takahashi, Keishi Makino, Masatoshi Takagaki, Jiro Akimoto, Takeshi Okuda, Yoshiko Okita, Koichi Mitsuya, Yasuyuki Hirashima, Yoshitaka Narita, Yoko Nakasu, On Behalf of the Committee of Brain Tumor Registry of Japan Supported by the Japan Neurosurgical Society
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-7 (2017)
Abstract Background The prevalence of brain metastases (BM) from uterine cancer has recently increased because of the improvement of overall survival (OS) of patients with uterine cancer due to its early detection and improved local control as a resu
Externí odkaz:
https://doaj.org/article/c01f979e4a9a43079c48d96a4d4358bd
Autor:
Satoshi Takahashi, Masamichi Takahashi, Manabu Kinoshita, Mototaka Miyake, Risa Kawaguchi, Naoki Shinojima, Akitake Mukasa, Kuniaki Saito, Motoo Nagane, Ryohei Otani, Fumi Higuchi, Shota Tanaka, Nobuhiro Hata, Kaoru Tamura, Kensuke Tateishi, Ryo Nishikawa, Hideyuki Arita, Masahiro Nonaka, Takehiro Uda, Junya Fukai, Yoshiko Okita, Naohiro Tsuyuguchi, Yonehiro Kanemura, Kazuma Kobayashi, Jun Sese, Koichi Ichimura, Yoshitaka Narita, Ryuji Hamamoto
Publikováno v:
Cancers, Vol 13, Iss 6, p 1415 (2021)
Machine learning models for automated magnetic resonance image segmentation may be useful in aiding glioma detection. However, the image differences among facilities cause performance degradation and impede detection. This study proposes a method to
Externí odkaz:
https://doaj.org/article/e0a4367e1a0a43adb1e0d11d42e6b6ce
Autor:
Hiroaki Wakimoto, Daniel P. Cahill, Mara V.A. Koerner, Julie J. Miller, Juri Kiyokawa, Alexandria L. Fink, Fumi Higuchi
Figure S1. A compound screen identifies Volasertib as potently cytotoxic to MSH6-deficient glioblastoma cells. Figure S2. The effects of temozolomide and PLK1 inhibitors on glioblastoma cells with and without MSH6 knockdown. Figure S3. Combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cd718b2ea402264d9a0713209e765a
https://doi.org/10.1158/1535-7163.22505719
https://doi.org/10.1158/1535-7163.22505719
Autor:
Daniel P. Cahill, Hiroaki Wakimoto, Julie J. Miller, Lisa Melamed, Seamus Rafferty, Megha Subramanian, Fumi Higuchi, Kensuke Tateishi, Christine K. Lee, Hiroaki Nagashima
NAD+ is an essential cofactor metabolite and is the currency of metabolic transactions critical for cell survival. Depending on tissue context and genotype, cancer cells have unique dependencies on NAD+ metabolic pathways. PARPs catalyze oligomerizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4548a0ba9bccfaa3383ec4606014a7bf
https://doi.org/10.1158/2159-8290.c.6547864.v1
https://doi.org/10.1158/2159-8290.c.6547864.v1
Autor:
Daniel P. Cahill, Hiroaki Wakimoto, Julie J. Miller, Lisa Melamed, Seamus Rafferty, Megha Subramanian, Fumi Higuchi, Kensuke Tateishi, Christine K. Lee, Hiroaki Nagashima
shRNA and Control shRNA Cell Lines, Molecular Analyses, 2-HG Quantitation, Western blot analysis, Immunohistochemistry, TUNEL assay, In Vivo Studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c8716f95ed0c3b990e58f050aa749e
https://doi.org/10.1158/2159-8290.22535455.v1
https://doi.org/10.1158/2159-8290.22535455.v1
Autor:
Hiroaki Wakimoto, Daniel P. Cahill, Mara V.A. Koerner, Julie J. Miller, Juri Kiyokawa, Alexandria L. Fink, Fumi Higuchi
Mismatch repair (MMR) deficiency through MSH6 inactivation has been identified in up to 30% of recurrent high-grade gliomas, and represents a key molecular mechanism underlying the acquired resistance to the alkylating agent temozolomide (TMZ). To de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45088be653fc7c4ec45fccf45ecbba8
https://doi.org/10.1158/1535-7163.c.6538159.v1
https://doi.org/10.1158/1535-7163.c.6538159.v1
Autor:
Daniel P. Cahill, Hiroaki Wakimoto, Mara V.A. Koerner, Jianfang Ning, Hiroaki Nagashima, Fumi Higuchi
XRCC1 inactivation does not restore the sensitivity to TMZ in MSH6-deficient cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd5a0ca4125b8fec92cb1626c0ef93f
https://doi.org/10.1158/1078-0432.22479261
https://doi.org/10.1158/1078-0432.22479261
Autor:
Daniel P. Cahill, Andrew S. Chi, Hiroaki Wakimoto, A. John Iafrate, Tracy T. Batchelor, David E. Fisher, Shota Tanaka, Ganesh M. Shankar, Nina Lelic, Mara V.A. Koerner, Julie J. Miller, Fumi Higuchi, Kensuke Tateishi
''Temozolomide induced PARP activation deregulates NAD metabolism. Additive cytotoxic effect of TMZ and NAMPT inhibitors in IDH1 mutant cancers. NAD and cell viability effects with TMZ and NAMPT inhibitors in endogenous IDH1 mutant cancers. Combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b79fb98b087ca59891878deccffc1a
https://doi.org/10.1158/0008-5472.22414470
https://doi.org/10.1158/0008-5472.22414470
Autor:
Daniel P. Cahill, Andrew S. Chi, Hiroaki Wakimoto, A. John Iafrate, Tracy T. Batchelor, David E. Fisher, Shota Tanaka, Ganesh M. Shankar, Nina Lelic, Mara V.A. Koerner, Julie J. Miller, Fumi Higuchi, Kensuke Tateishi
'Temozolomide induced PARP activation deregulates NAD metabolism. Additive cytotoxic effect of TMZ and NAMPT inhibitors in IDH1 mutant cancers. NAD and cell viability effects with TMZ and NAMPT inhibitors in endogenous IDH1 mutant cancers. Combinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db5b72ee868a5ab4604d97aa79dcc19
https://doi.org/10.1158/0008-5472.22414467.v1
https://doi.org/10.1158/0008-5472.22414467.v1