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Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Autor: Bannas, Peter, Lenz, Alexander, Kunick, Valentin, Fumey, William, Rissiek, Björn, Schmid, Joanna, Haag, Friedrich, Leingärtner, Axel, Trepel, Martin, Adam, Gerhard, Koch-Nolte, Friedrich

Publikováno v: Journal of Visualized Experiments : JoVE

This protocol outlines the steps required to perform ex vivo validation of in vivo near-infrared fluorescence (NIRF) xenograft imaging experiments in mice using fluorophore labelled nanobodies and conventional antibodies. First we describe how to gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f2d88f7263175da07038bdf97a13e9d4
http://europepmc.org/articles/PMC4401403

CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.

Autor: Schütze, Kerstin, Petry, Katharina, Hambach, Julia, Schuster, Niklas, Fumey, William, Schriewer, Levin, Röckendorf, Jana, Menzel, Stephan, Albrecht, Birte, Haag, Friedrich, Stortelers, Catelijne, Bannas, Peter, Koch-Nolte, Friedrich

Publikováno v: Frontiers in Immunology; 11/19/2018, pN.PAG-N.PAG, 11p

Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo

Autor: Friedrich Koch-Nolte, Ralf Fliegert, Kerstin Schütze, Mandy Unger, Friedrich Haag, Valentin Kunick, Fernando Alberto Goldbaum, Andreas H. Guse, Fabio Malavasi, William Fumey, Peter Bannas, Hon Cheung Lee, Rob van Hegelsom, Levin Schriewer, Yong Juan Zhao, Stephan Menzel, Anna Oberle, Gerhard Adam, Julia Koenigsdorf, Mascha Binder, Catelijne Stortelers

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The cell surface ecto-enzyme CD38 is a promising target antigen for the treatment of hematological malignancies, as illustrated by the recent approval of daratumumab for the treatment of multiple myeloma. Our aim was to evaluate the potential of CD38

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df67fb921991a528aa6a4feae0aaea2
http://hdl.handle.net/2318/1654403