Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy

Autor: Lei Wang, Jia Gao, Rongsheng Ma, Yaqian Liu, Mingqing Liu, Fumei Zhong, Jie Hu, Shuju Li, Jihui Wu, Hualiang Jiang, Jiahai Zhang, Ke Ruan

Publikováno v: Magnetic Resonance Letters, Vol 2, Iss 2, Pp 107-118 (2022)

Considerable developments have been observed in fragment-based lead/drug discovery (FBLD/FBDD) recently, with four drugs approved and many others under investigation. Nuclear magnetic resonance (NMR) has gained increasing popularity in FBLD due to it

Externí odkaz: https://doaj.org/article/c2fc70698ead422fb2c1e436641197ab

Resonance assignments of the PUB domain of the RNF31 protein

Autor: Lanlan Song, Fumei Zhong, Jiahai Zhang, Xiaoming Tu

RNF31 is identified in human proteins and is involved in activities of the linear ubiquitin chain assembly complex (LUBAC) and cell growth. RNF31 plays an important role in LUBAC-mediated ubiquitination. Here, we report the backbone and side-chain re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::518b7c68b6f64f8788ca10a9b2e41d30
https://doi.org/10.21203/rs.3.rs-2442972/v1

Inhibitors against Two PDZ Domains of MDA-9 Suppressed Migration of Breast Cancer Cells.

Autor: Tang, Heng^1,2 (AUTHOR), Wang, Lei² (AUTHOR), Li, Shuju² (AUTHOR), Wei, Xiaoli² (AUTHOR), Lv, Mengqi² (AUTHOR), Zhong, Fumei² (AUTHOR), Liu, Yaqian² (AUTHOR), Liu, Jiuyang³ (AUTHOR), Fu, Bangguo² (AUTHOR), Zhu, Qizhi^1,2 (AUTHOR), Wang, Dan² (AUTHOR), Liu, Jiajia² (AUTHOR), Ruan, Ke² (AUTHOR), Gao, Jia² (AUTHOR) jiagao@ustc.edu.cn, Xu, Weiping^1,2 (AUTHOR) jiagao@ustc.edu.cn

Publikováno v: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3431. 14p.

Data on Breast Cancer Described by Researchers at Chinese Academy of Sciences (Inhibitors against Two PDZ Domains of MDA-9 Suppressed Migration of Breast Cancer Cells).

Publikováno v: Women's Health Weekly; 3/14/2023, p172-172, 1p