Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Fulya Koksalar Alkan"'
Autor:
Fulya Koksalar Alkan, Ahmet Burak Caglayan, Hilmi Kaan Alkan, Elayne Benson, Yunus Emre Gunduz, Ozge Sensoy, Serdar Durdagi, Elbrus Zarbaliyev, Greg Dyson, Hadeel Assad, Austin Shull, Ahmed Chadli, Huidong Shi, Gurkan Ozturk, Hasan Korkaya
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Triple negative breast cancer (TNBC) subtype is characterized with higher EMT/stemness properties and immune suppressive tumor microenvironment (TME). Women with advanced TNBC exhibit aggressive disease and have limited treatment options. Al
Externí odkaz:
https://doaj.org/article/4c7feb8b8c1e4a10878a6afdd1f9525f
Autor:
Nilufer Sayar-Atasoy, Connor Laule, Iltan Aklan, Hyojin Kim, Yavuz Yavuz, Tayfun Ates, Ilknur Coban, Fulya Koksalar-Alkan, Jacob Rysted, Debbie Davis, Uday Singh, Muhammed Ikbal Alp, Bayram Yilmaz, Huxing Cui, Deniz Atasoy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Norepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system is targeted by several anti-obesity drugs. To better understand the circuitry underlying adrenergic appetite control, here we investigated the paraventricu
Externí odkaz:
https://doaj.org/article/7a7b6b87fc4048c38a3160aeb85e4c0d
Autor:
Hasan Korkaya, Elayne Benson, Fulya Koksalar Alkan, Justin Wilson, Tulshi Patel, Hilmi K. Alkan, Virginia McEvoy, Nika Shekastehband, Nate Francois, Huidong Shi, Catherine C. Hedrick
Publikováno v:
Cancer Research. 83:4600-4600
Despite the advances in early diagnostics and therapeutics, women with metastatic breast cancer have limited treatment options. Women with TNBC, who constitute 15-20% of breast cancer patients, are often diagnosed with aggressive/metastatic disease.
Autor:
Fulya Koksalar Alkan, Justin Wilson, Elayne Benson, Tulshi Patel, Virginia McEvoy, Nate Francois, Emma Nguyen, Hilmi Kaan Alkan, Ahmed Chadli, Jason Gestwicki, Hasan Korkaya
Publikováno v:
Cancer Research. 83:4606-4606
We previously demonstrated that upregulation of A20 in TNBC subtype in response to TNFα protects these cells from cytotoxic cell death by upregulating HSP70 protein and maintaining EMT/CSC phenotype. In contrast, luminal MCF7 or ZR75-1 cells display
Autor:
Max S. Wicha, Hasan Korkaya, Fulya Koksalar Alkan, Z. Ece Arslan, Esra Altintas, Raziye Piranlioglu, Eunmi Lee
Publikováno v:
Immunology.
Large cohorts of recent clinical studies have firmly established that increased levels of tumor-infiltrating lymphocytes (TILs) in TNBC and HER2+ subtypes predicted better clinical outcome compared to the luminal subtype. These observations led to th
Autor:
Fulya Koksalar Alkan, Hasan Korkaya
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-2 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
In a recent article published in Cell, Molgora et al.1 reported that asubset of tumor-infiltrating macrophages with TREM2 expressioncreates an immunosuppressive microenvironment that promotestumor growth while suppressing anti-tumor immune responses.