Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Fulvio Guano"'
Autor:
Ernesto Menta, Ambrogio Oliva, Giuseppe Zagotto, Manlio Palumbo, Fulvio Guano, Giovanni Capranico
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:121-126
New bisantrene analogues were synthesized, bearing one or two 4,5-dihydro-1H-imidazol-2-yl hydrazone side chains at positions 1,4 or 9 of the anthracene ring system. A 10-azabioisostere was also prepared. The position of substituents in structurally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f2969e3fee81b2ec3bd4c01d8cf207
https://doi.org/10.1016/s0960-894x(97)10207-4
https://doi.org/10.1016/s0960-894x(97)10207-4
Publikováno v:
Journal of Biological Chemistry. 270:28357-28363
Type II topoisomerases are essential for faithful cell division in all organisms. In human cells, the α isozyme of topoisomerase II has been implicated in catalyzing mitotic chromosome segregation via its action as a DNA unlinking enzyme. Here, we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1355ed2f4dcb6cc109bf684f94aca3d
https://doi.org/10.1074/jbc.270.47.28357
https://doi.org/10.1074/jbc.270.47.28357
Publikováno v:
Experimental Cell Research. 206:128-133
DNA topoisomerase I and the isoforms alpha and beta of DNA topoisomerase II were analyzed in different animal cells using a panel of monoclonal antibodies (MoAbs). The beta isoform is a most unstable enzyme. We investigated conditions to stabilize be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8101d7e877179998b2f9beae3f3ed1fd
https://doi.org/10.1006/excr.1993.1128
https://doi.org/10.1006/excr.1993.1128
Autor:
Ambrogio Oliva, Manlio Palumbo, Fulvio Guano, Giovanni Capranico, Ernesto Menta, Giuseppe Zagotto
Publikováno v:
ChemInform. 29
New bisantrene analogues were synthesized, bearing one or two 4,5-dihydro-1H-imidazol-2-yl hydrazone side chains at positions 1,4 or 9 of the anthracene ring system. A 10-azabioisostere was also prepared. The position of substituents in structurally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef5cc5c6cd38827953e3fa74b8ee16ed
https://doi.org/10.1002/chin.199818119
https://doi.org/10.1002/chin.199818119
Autor:
Monica Tortoreto, Rosanna Supino, Raffaella Pavesi, Federica Facchinetti, Laura Dal Bo, Gabriella Pezzoni, Ernesto Menta, Silvia Richter, Dante Torriani, Claudia Sissi, Donatella Polizzi, Nives Carenini, Giovanni Capranico, Manlio Palumbo, Silvano Spinelli, Gino Beggiolin, Fulvio Guano, Franco Zunino, Graziella Pratesi
Objectives: Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823e34adb6d76ca739b679a41c8393d0
http://hdl.handle.net/11577/2467700
http://hdl.handle.net/11577/2467700
Autor:
Yves Pommier, Stefano Manzini, Stella Tinelli, Glenda Kohlhagen, Fabio Animati, Philippe Pourquier, Giovanni Capranico, Mario Bigioni, Monica Binaschi, Fulvio Guano, Franco Zunino
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 1999, 56 (1), pp.77-84. ⟨10.1124/mol.56.1.77⟩
Scopus-Elsevier
ResearcherID
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 1999, 56 (1), pp.77-84. ⟨10.1124/mol.56.1.77⟩
Scopus-Elsevier
ResearcherID
International audience; Doxorubicin and idarubicin are very effective anticancer drugs in the treatment of human hematological malignancies and solid tumors. These agents are well known topoisomerase II poisons; however, some anthracycline analogs re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14044858990b6c0a855a5fed9e0bb301
https://doi.org/10.1124/mol.56.1.77
https://doi.org/10.1124/mol.56.1.77
Autor:
Ernesto Menta, Stefano Moro, Barbara Gatto, Fulvio Guano, Franco Zunino, Giuseppe Zagotto, Claudia Sissi, Manlio Palumbo, Giovanni Capranico
Publikováno v:
The Journal of biological chemistry. 273(21)
To identify structural determinants for the sequence-specific recognition of covalent topoisomerase II-DNA complexes by anti-cancer drugs, we investigated a number of bisantrene congeners, including a 10-azabioisoster, bearing one or two 4, 5-dihydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632579e9618a4bd0f4a5a314b1c6e698
https://pubmed.ncbi.nlm.nih.gov/9582297
https://pubmed.ncbi.nlm.nih.gov/9582297
Publikováno v:
Scopus-Elsevier
Topoisomerase II was partially purified from Daucus carota cells by a procedure including ammonium sulphate fractionation, ion-exchange, and affinity chromatography steps. The type II enzyme, identified for its ability to unknot knotted P4 DNA and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7e13476c8fc2e4133020f6d075fb9e
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029161281&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029161281&partnerID=MN8TOARS
Autor:
Fulvio Guano, Umberto Bertazzoni, Anne-Mieke Vandamme, M. Salemi, Chiara Gradozzi, E Cattaneo, Claudio Casoli
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
The complete nucleotide sequence of a human T-cell lymphotropic virus type II isolate (HTLV-II-Gu) from an Italian injecting drug user was obtained, representing the first entire sequence of a European HTLV-II isolate. The HTLV-II-Gu genome was more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba15baab5f7d68910d3fe4549c6ae4b
http://europepmc.org/abstract/med/8683207
http://europepmc.org/abstract/med/8683207