Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Fulvio Grigolato"'
Autor:
Miriam Linsenmeier, Maria Hondele, Fulvio Grigolato, Eleonora Secchi, Karsten Weis, Paolo Arosio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here the authors analyze material properties and aging of active phase-separated condensates by Differential Dynamic Microscopy. Arrested states are promoted by structured RNA. Low-complexity domains and biochemical reaction keep the droplets fluid-l
Externí odkaz:
https://doaj.org/article/37e5083619774cda9c11b6dec46c61b4
Autor:
Marie R.G. Kopp, Fulvio Grigolato, Dominik Zürcher, Tapan K. Das, Danny Chou, Klaus Wuchner, Paolo Arosio
Publikováno v:
Journal of Pharmaceutical Sciences. 112:377-385
Protein stability against aggregation is a major quality concern for the production of safe and effective biopharmaceuticals. Amongst the different drivers of protein aggregation, increasing evidence indicates that interactions between proteins and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e34a8b95b9fe829c66531141ab236b8
https://doi.org/10.1016/j.xphs.2022.10.009
https://doi.org/10.1016/j.xphs.2022.10.009
Autor:
Tianjin Yang, Alessia Villois, Antonín Kunka, Fulvio Grigolato, Paolo Arosio, Zbynek Prokop, Andrew deMello, Stavros Stavrakis
Publikováno v:
Analytical Chemistry, 94 (48)
Protein folding, unfolding, and aggregation are important in a variety of biological processes and intimately linked to “protein misfolding diseases”. The ability to perform experiments at different temperatures allows the extraction of important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003960a665f5df3405c49d625e5d0def
https://pubmed.ncbi.nlm.nih.gov/36395420
https://pubmed.ncbi.nlm.nih.gov/36395420
Autor:
Fulvio Grigolato, Paolo Arosio
Publikováno v:
Biotechnology and Bioengineering. 117:417-428
During the manufacturing process, solutions of protein-based drugs are exposed to hydrodynamic forces, which can potentially affect protein stability and aggregation. Despite being an area of extensive investigation, the effect of hydrodynamic flow o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97887af05b19ea9e8ed525c81f3b8900
https://doi.org/10.1002/bit.27212
https://doi.org/10.1002/bit.27212
Autor:
Paolo Arosio, Fulvio Grigolato
Publikováno v:
Physical Chemistry Chemical Physics. 21:1435-1442
In vitro kinetic assays of amyloid formation represent a central tool in many areas of biotechnological and biomedical sciences, including drug discovery against a variety of neurodegenerative disorders. The conversion of soluble peptides and protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d030c8235cf490bb748c155dbe922152
https://doi.org/10.1039/c8cp05904g
https://doi.org/10.1039/c8cp05904g
Autor:
Lenka Faltova, Andreas M. Küffner, Umberto Capasso Palmiero, Miriam Linsenmeier, Paolo Arosio, Fulvio Grigolato, Remo Zuccarini, Marc Prodan
Publikováno v:
Chemical Science, 12 (12)
Chemical Science
Chemical Science
Biomolecular condensates are emerging as an efficient strategy developed by cells to control biochemical reactions in space and time by locally modifying composition and environment. Yet, local increase in protein concentration within these compartme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d230927fd2ebfcd9ddf1daf285a9c88a
https://hdl.handle.net/20.500.11850/478092
https://hdl.handle.net/20.500.11850/478092
Autor:
Fulvio Grigolato, Paolo Arosio
Publikováno v:
Biotechnology and Bioengineering. 117
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::028cefa706ca1d793fb7e3d75e0e2936
https://doi.org/10.1002/bit.27036
https://doi.org/10.1002/bit.27036
Publikováno v:
AllergyREFERENCES. 75(6)
Background: Regulation of neutrophil chemotaxis and activation plays crucial roles in immunity, and dysregulated neutrophil responses can lead to pathology as seen in neutrophilic asthma. Neutrophil recruitment is key for initiating immune defense an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a4fa4ac5e80718b3e611337a9e81b4
https://pubmed.ncbi.nlm.nih.gov/31971608
https://pubmed.ncbi.nlm.nih.gov/31971608
Autor:
Paolo Arosio, Marie R.G. Kopp, Umberto Capasso Palmiero, Fulvio Grigolato, Karsten Weis, Miriam Linsenmeier, Leonidas Emmanoulidis, Maria Hondele, Dany Liu, Dominik Zürcher
Publikováno v:
Angewandte Chemie. International Edition, 58 (41)
Cells can form membraneless organelles by liquid-liquid phase separation. As these organelles are highly dynamic, it is crucial to understand the kinetics of these phase transitions. Here, we use droplet-based microfluidics to mix reagents by chaotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8011f937d90dca4f3e419f3d23c24cfc
https://pubmed.ncbi.nlm.nih.gov/31797500
https://pubmed.ncbi.nlm.nih.gov/31797500
Autor:
Fulvio Grigolato, Paolo Arosio
Publikováno v:
Biophysical Chemistry, 270
Interfaces can strongly accelerate or inhibit protein aggregation, destabilizing proteins that are stable in solution or, conversely, stabilizing proteins that are aggregation-prone. Although this behaviour is well-known, our understanding of the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3436df0b0e923506796779cedc0bf8
https://doi.org/10.1016/j.bpc.2020.106533
https://doi.org/10.1016/j.bpc.2020.106533