Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fulvia Roletto"'
Autor:
Marina Ciomei, Ciro Mercurio, Enrico Pesenti, Jurgen Moll, Antonella Isacchi, Arturo Galvani, Francesco Colotta, Fulvia Roletto, Veronica Patton, Wilma Pastori, Giuseppe Locatelli, Francesco Fiorentini, Claudio Festuccia, Maria Gabriella Brasca, Dario Ballinari, Nilla Avanzi, Nadia Amboldi, Rachele Alzani, Clara Albanese
Altered expression and activity of cyclin-dependent kinase (CDK) and tropomyosin receptor kinase (TRK) families are observed in a wide variety of tumors. In those malignancies with aberrant CDK activation, the retinoblastoma protein (pRb) pathway is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bb653415d9936d93679b97e43a99b1
https://doi.org/10.1158/1535-7163.c.6532245.v1
https://doi.org/10.1158/1535-7163.c.6532245.v1
Autor:
Matthew V. Lorenzi, Wayne Vaccaro, Marco M. Gottardis, Simona Bindi, Michael A. Poss, Sandrine Thieffine, George L. Trainor, Lata Jayaraman, Paola Vianello, Fulvia Roletto, Ashok V. Purandare, Suhong Pang, Zhong Chen, Tram N. Huynh, Arturo Galvani, Jieping Geng, Tiziano Bandiera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2924-2927
Design, synthesis, and SAR development led to the identification of the potent, novel, and selective pyrazole based inhibitor (7f) of Coactivator Associated Arginine Methyltransferase (CARM1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769baa6101ece04febd20a1b6b99029b
https://doi.org/10.1016/j.bmcl.2009.04.075
https://doi.org/10.1016/j.bmcl.2009.04.075
Autor:
Sabrina Cribioli, Eduard R. Felder, Nadia Amboldi, Laura Mancini, Dario Ballinari, Claudia Perrera, Fabio Gasparri, Daniela Asa, Elena Casale, Elena Ardini, Fulvia Roletto, Marina Fasolini, Stefania Re Depaolini, Davide Carenzi, Marina Ciomei, Daniele Casero, Simona Rizzi, Maurizio Pulici, Patrizia Banfi, Antonella Isacchi, Daniele Donati, Arturo Galvani, Ilaria Motto, Barbara Valsasina, Simona Bindi
Publikováno v:
Cancer Research. 77:5163-5163
PERK (PKR-like endoplasmic reticulum kinase) is a serine-threonine kinase associated to endoplasmic reticulum membrane. Together with ATF6 and IRE1, PERK is a key effector of the Unfolded Protein Response (UPR), a network of signaling pathways that e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::052f4395948a293c2f16ba558b863246
https://doi.org/10.1158/1538-7445.am2017-5163
https://doi.org/10.1158/1538-7445.am2017-5163
Autor:
Marco Tato, Paolo Orsini, Ermes Vanotti, Francesco Fiorentini, Arturo Galvani, Valter Croci, Fabrizio Orzi, Cristina Alli, Jurgen Moll, Maristella Colombo, Roberto D'Alessio, Alberto Bargiotti, Barbara Forte, Enrico Pesenti, Katia Martina, Clara Albanese, Matteo D'anello, Barbara Valsasina, Mario Varasi, Patrizia Giordano, Antonella Isacchi, Alessandra Cirla, Marcellino Tibolla, Antonio Pillan, Antonella Ciavolella, Alessandra Scolaro, Paola Vianello, Fulvia Roletto, Antonella Ermoli, Antonio Molinari, Daniele Volpi, Alessia Montagnoli, Corrado Santocanale, Maria Menichincheri, Francesco Colotta, Dario Ballinari, Marina Caldarelli
Publikováno v:
Journal of medicinal chemistry. 53(20)
Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small molecules causes p53 independent apoptosis in tumor cells while reversibly arresting cell cycle progression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f5eb7387810f718a9ade2872752cfa
https://pubmed.ncbi.nlm.nih.gov/20873740
https://pubmed.ncbi.nlm.nih.gov/20873740
Autor:
Francesco Fiorentini, Jürgen Moll, Marina Ciomei, Enrico Pesenti, Nilla Avanzi, Maria Gabriella Brasca, Rachele Alzani, Nadia Amboldi, Ciro Mercurio, Antonella Isacchi, Claudio Festuccia, Veronica Patton, Clara Albanese, Giuseppe Locatelli, Wilma Pastori, Dario Ballinari, Arturo Galvani, Francesco Colotta, Fulvia Roletto
Publikováno v:
Molecular cancer therapeutics. 9(8)
Altered expression and activity of cyclin-dependent kinase (CDK) and tropomyosin receptor kinase (TRK) families are observed in a wide variety of tumors. In those malignancies with aberrant CDK activation, the retinoblastoma protein (pRb) pathway is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9b3e1efa20b976b1bbb35ac903e864
https://pubmed.ncbi.nlm.nih.gov/20682657
https://pubmed.ncbi.nlm.nih.gov/20682657
Autor:
Michele Caruso, Francesco Fiorentini, Francesco Sola, Maria Laura Giorgini, Laura Gianellini, Italo Beria, Fulvia Roletto, Maria Gabriella Brasca, Maristella Colombo, Barbara Valsasina, Ron Ferguson, Gabriele Fachin, Dania Tesei, Helena Posteri, Jurgen Moll, Walter Ceccarelli, Daniele Pezzetta, Sabrina Cribioli
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
A series of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives was optimized as Polo-like kinase 1 inhibitors. Extensive SAR afforded a highly potent and selective PLK1 compound. The compound showed good antiproliferative activity when tested in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93859b798e1a9fac70cabff937780dcf
https://pubmed.ncbi.nlm.nih.gov/20932759
https://pubmed.ncbi.nlm.nih.gov/20932759
Autor:
Achille Panzeri, Anna Vulpetti, Francesco Colotta, Wilma Pastori, Gabriella Traquandi, Valter Croci, Nadia Amboldi, Maria Gabriella Brasca, Elena Casale, Maristella Colombo, Antonella Isacchi, Alexander D. Cameron, Moretti W, Francesco Fiorentini, Paola Vianello, Fulvia Roletto, Roberto D'Alessio, Ciro Mercurio, Dario Ballinari, Giovanni Cervi, Francesca Quartieri, Paolo Pevarello, Marina Ciomei
Publikováno v:
Journal of medicinal chemistry. 52(16)
The discovery of a novel class of inhibitors of cyclin dependent kinases (CDKs) is described. Starting from compound 1, showing good potency as inhibitor of CDKs but being poorly selective against a panel of serine−threonine and tyrosine kinases, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee8f21041e8c8948548ffa3bb73ea40
https://pubmed.ncbi.nlm.nih.gov/19603809
https://pubmed.ncbi.nlm.nih.gov/19603809
Autor:
Maria Menichincheri, Alessia Montagnoli, Antonella Ciavolella, Katia Martina, Ermes Vanotti, Mario Varasi, Alessandra Cirla, Roberto D'Alessio, Cinzia Cristiani, Daniele Volpi, Alessandra Scolaro, Alberto Bargiotti, Barbara Valsasina, Marcellino Tibolla, Roberta Bosotti, Antonella Isacchi, Raffaella Amici, Antonio Pillan, Paolo Orsini, Barbara Forte, Antonio Molinari, Fulvia Roletto, Jens Berthelsen, Corrado Santocanale
Cdc7 kinase is an essential protein that promotes DNA replication in eukaryotic organisms. Genetic evidence indicates that Cdc7 inhibition can cause selective tumor-cell death in a p53-independent manner, supporting the rationale for developing Cdc7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8177c69e67dae7b2d00ac0785fd36e
http://hdl.handle.net/2318/93819
http://hdl.handle.net/2318/93819
Autor:
Wilma Pastori, Francesco Fiorentini, Paolo Orsini, Ettore Perrone, Dario Ballinari, Federico Riccardi-Sirtori, Maria Gabriella Brasca, Paolo Pevarello, Valter Croci, Enrico Pesenti, Patrick Roussel, Luca Corti, Ciro Mercurio, Daniele Fancelli, Clara Albanese, Fulvia Roletto, Raffaella Amici, Anna Vulpetti, Marcella Nesi, Fabrizio Orzi, Mario Varasi
Publikováno v:
ChemMedChem. 2(6)
We have recently reported a new class of CDK2/cyclin A inhibitors based on a bicyclic tetrahydropyrrolo[3,4-c]pyrazole scaffold. The introduction of small alkyl or cycloalkyl groups in position 6 of this scaffold allowed variation at the other two di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20a860cacea03a3a1e9e414f0993e51
https://pubmed.ncbi.nlm.nih.gov/17450625
https://pubmed.ncbi.nlm.nih.gov/17450625
Autor:
Patrizia Carpinelli, Paolo Cappella, Walter Croci, D. Berta, Aurelio Marsiglio, Paola Zugnoni, Paola Storici, Maurizio Rocchetti, Jan Klapwijk, Barbara Forte, Enrico Pesenti, Chiara Soncini, Ilaria Candiani, Paola Vianello, Fulvia Roletto, Simona Bindi, Alexander D. Cameron, Dino Severino, Maria Laura Giorgini, Roberta Artico, Jurgen Moll, Roberto Tonani, Daniele Fancelli, Mario Varasi, Rodrigo Bravo
Publikováno v:
Journal of medicinal chemistry. 49(24)
The optimization of a series of 5-phenylacetyl 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives toward the inhibition of Aurora kinases led to the identification of compound 9d. This is a potent inhibitor of Aurora kinases that also shows low nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd08cc812dadec488b873749bc6bc115
https://pubmed.ncbi.nlm.nih.gov/17125279
https://pubmed.ncbi.nlm.nih.gov/17125279