Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2.

Autor: Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Fiala B; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Wrenn S; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Pham MN; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Murphy M; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Tse LV; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Shehata L; Department of Immunology, University of Washington, Seattle, WA 98109, USA., O'Connor MA; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, Seattle, WA 98121, USA., Chen C; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.; Biological Physics Structure and Design Program, University of Washington, Seattle, WA 91895, USA., Navarro MJ; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Miranda MC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Pettie D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Ravichandran R; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Kraft JC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Ogohara C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Palser A; Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom., Chalk S; Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom., Lee EC; Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom., Kepl E; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Chow CM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Sydeman C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Hodge EA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., Brown B; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, Seattle, WA 98121, USA., Fuller JT; Department of Microbiology, University of Washington, Seattle, WA 98109, USA., Dinnon KH 3rd; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Gully KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Lewis TB; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, Seattle, WA 98121, USA., Guttman M; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., Chu HY; Department of Medicine, University of Washington, Seattle, WA 98109, USA., Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.; Biological Physics Structure and Design Program, University of Washington, Seattle, WA 91895, USA., Fuller DH; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, Seattle, WA 98121, USA.; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Kellam P; Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.; Department of Infectious Disease, Imperial College London, United Kingdom., Carter L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Pepper M; Department of Immunology, University of Washington, Seattle, WA 98109, USA., Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., King NP; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; institute for Protein Design, University of Washington, Seattle, WA 98195, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Aug 12. Date of Electronic Publication: 2020 Aug 12.