17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease and progressive supranuclear palsy converge on altered glial regulation

Autor: Bowles, KR, Pugh, DA, Farrell, K, Han, N, TCW, J, Liu, Y, Liang, SA, Qian, L, Bendl, J, Fullard, JF, Renton, AE, Casella, A, Iida, MA, Bandres-Ciga, S, Gan-Or, Z, Heutink, P, Siitonen, A, Bertelsen, S, Karch, CM, Frucht, SJ, Kopell, BH, Peter, I, Park, YJ, Crane, PK, Kauwe, JSK, Boehme, KL, Höglinger, GU, Charney, A, Roussos, P, Wang, JC, Poon, WW, Raj, T, Crary, JF, Goate, AM

Parkinson’s disease (PD) and progressive supranuclear palsy (PSP) are clinically similar neurodegenerative movement disorders that display unique neuropathological features (i.e. Lewy body pathology and Tau pathology, respectively). While each diso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::2d6706e6d97f237d2d7028adee6d4ff1

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A multi-region single nucleus transcriptomic atlas of Parkinson's disease.

Autor: N M P; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fullard JF; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Clarence T; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mathur D; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research Education and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, Bronx, NY, USA., Casey C; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hennigan E; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Alvia M; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krause-Massaguer J; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Barreda A; Brain Endowment Bank, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Davis DA; Brain Endowment Bank, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Vontell RT; Brain Endowment Bank, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Garamszegi SP; Brain Endowment Bank, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Sang L; McLean Hospital, Belmont, MA, USA., Chatigny M; McLean Hospital, Belmont, MA, USA., Vismer D; Technome LLC, Herndon, VA, USA., Landin B; Technome LLC, Herndon, VA, USA., Burstein D; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research Education and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, Bronx, NY, USA., Lee D; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Voloudakis G; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research Education and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, Bronx, NY, USA., Berretta S; McLean Hospital, Belmont, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Haroutunian V; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research Education and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Scott WK; Brain Endowment Bank, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Bendl J; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jaroslav.bendl@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jaroslav.bendl@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jaroslav.bendl@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jaroslav.bendl@mssm.edu., Roussos P; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Mental Illness Research Education and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA. panagiotis.roussos@mssm.edu.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, Bronx, NY, USA. panagiotis.roussos@mssm.edu.

Publikováno v: Scientific data [Sci Data] 2024 Nov 23; Vol. 11 (1), pp. 1274. Date of Electronic Publication: 2024 Nov 23.

Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders.

Autor: Zhou B; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Maternal and Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: bozhou@alumni.stanford.edu., Arthur JG; Department of Statistics, Stanford University, Stanford, CA 94305, USA., Guo H; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Maternal and Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Statistics, Stanford University, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA., Kim T; School of Computer Science and Engineering, Pusan National University, Busan 46241, South Korea., Huang Y; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Pattni R; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Wang T; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Kundu S; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA., Luo JXJ; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Lee H; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA., Nachun DC; Department of Pathology, Stanford University, Stanford, CA 94305, USA., Purmann C; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Maternal and Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Monte EM; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Weimer AK; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Qu PP; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Shi M; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Jiang L; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Yang X; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Fullard JF; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Bendl J; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Girdhar K; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Kim M; School of Computer Science and Engineering, Pusan National University, Busan 46241, South Korea., Chen X; Department of Statistics, Stanford University, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA., Greenleaf WJ; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Duncan L; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA., Ji HP; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA., Zhu X; Department of Statistics, Stanford University, Stanford, CA 94305, USA; Department of Statistics, Pennsylvania State University, University Park, PA 16802, USA; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA., Song G; School of Computer Science and Engineering, Pusan National University, Busan 46241, South Korea; Center for Artificial Intelligence Research, Pusan National University, Busan 46241, South Korea., Montgomery SB; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Maternal and Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University, Stanford, CA 94305, USA., Palejev D; Institute of Mathematics and Informatics, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria., Zu Dohna H; Department of Biology, American University of Beirut, Beirut 11-0236, Lebanon., Roussos P; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, Bronx, NY 10468, USA; Mental Illness Research Education and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY 10468, USA., Kundaje A; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA., Hallmayer JF; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA., Snyder MP; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Wong WH; Department of Statistics, Stanford University, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA. Electronic address: whwong@stanford.edu., Urban AE; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Maternal and Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: aeurban@stanford.edu.

Publikováno v: Cell [Cell] 2024 Nov 14; Vol. 187 (23), pp. 6687-6706.e25. Date of Electronic Publication: 2024 Sep 30.

Myocardial infarction augments sleep to limit cardiac inflammation and damage.

Autor: Huynh P; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoffmann JD; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, NYC Health and Hospitals/Elmhurst, Elmhurst, Queens, NY, USA., Gerhardt T; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Germany and Berlin Institute of Health, Berlin, Germany., Kiss MG; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zuraikat FM; Center of Excellence for Sleep and Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Cohen O; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wolfram C; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Germany and Berlin Institute of Health, Berlin, Germany., Yates AG; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Leunig A; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Heiser M; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gaebel L; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gianeselli M; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goswami S; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Khamhoung A; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Downey J; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yoon S; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen Z; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Roudko V; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dawson T; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ferreira da Silva J; Center for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Ameral NJ; Department of Pathology, Harvard Medical School, Boston, MA, USA., Morgenroth-Rebin J; Center for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., D'Souza D; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Koekkoek LL; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jacob W; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Munitz J; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee D; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fullard JF; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., van Leent MMT; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Roussos P; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shah N; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kleinstiver BP; Center for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Swirski FK; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Leistner D; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Germany and Berlin Institute of Health, Berlin, Germany.; Department of Medicine, Cardiology/Angiology, Goethe University Hospital, Frankfurt, Germany., St-Onge MP; Center of Excellence for Sleep and Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., McAlpine CS; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.

Publikováno v: Nature [Nature] 2024 Nov; Vol. 635 (8037), pp. 168-177. Date of Electronic Publication: 2024 Oct 30.