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Publikováno v:
Cell and Tissue Banking
Graphical abstract Recent studies have demonstrated inhibitory effects of mesenchymal stem cells on breast tumors. Likewise, the emerging interest in statins as anticancer agents is based on their pleiotropic effects. In the present study, we investi
Autor:
Steven W. Hardwick, Amir Guppy, Charlotte E. Veale, Neil J. Rzechorzek, Mairi L. Kilkenny, Luca Pellegrini, Joseph D. Maman, Dimitri Y. Chirgadze
Publikováno v:
Protein Science : A Publication of the Protein Society
The molecular mechanisms that drive the infection by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)—the causative agent of coronavirus disease 2019 (COVID‐19)—are under intense current scrutiny to understand how the virus
Autor:
Tristan Tomala, Antoine Lagarde
Publikováno v:
Mathematical Programming
We consider the problem of optimal partisan gerrymandering: a legislator in charge of redrawing the boundaries of equal-sized congressional districts wants to ensure the best electoral outcome for his own party. The so-called gerrymanderer faces two
Publikováno v:
Cell and Tissue Banking
To gather information from stakeholders involved in corneal donation and transplantation to inform discussion at the “National Consensus Forum on Improving Cornea Donation and Transplantation Access in Canada” held in February 2020, survey questi
Autor:
Neel H. Shah, Christine L. Gee, John Kuriyan, Jean M. Badroos, Helen T. Hobbs, Susan Marqusee
Publikováno v:
Protein Science : A Publication of the Protein Society
The catalytic activity of Syk‐family tyrosine kinases is regulated by a tandem Src homology 2 module (tSH2 module). In the autoinhibited state, this module adopts a conformation that stabilizes an inactive conformation of the kinase domain. The bin
Autor:
Francesca Malagrinò, Serena Rinaldo, Angelo Toto, Stefano Gianni, Caterina Nardella, Livia Pagano
Publikováno v:
Protein Science : A Publication of the Protein Society
SH2 domains are a class of protein–protein interaction modules with the function to recognize and bind sequences characterized by the presence of a phosphorylated tyrosine. SHP2 is a protein phosphatase involved in the Ras‐ERK1/2 signaling pathwa
Autor:
Giuseppe Piccolo, Barbara Micheli, Giorgio Mastroiacovo, Alice Bonomi, Francesca Capriuoli, Luca Dainese, Anna Guarino, Marco Gennari, Gianluca Polvani, Sergio Pirola
Publikováno v:
Cell and Tissue Banking
The worldwide pandemic outbreak due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has created unprecedented challenges for public health services. Lombardy, region of the Northern Italy, has been the first area in the Western world
Publikováno v:
Protein Science. 31
The cell biology and biochemistry of peptide exchange on major histocompatibility complex class I (MHC-I) proteins are of great interest in the study of immunodominance, which requires iterative optimization of peptide affinity, and cross-presentatio
Autor:
Tomonari Sumi, Hiroshi Imamura
Publikováno v:
Protein Science : A Publication of the Protein Society
Proteins are folded to avoid exposure of the non-polar groups to water because water-mediated interactions between nonpolar groups are a promising factor in the thermodynamic stabilities of proteins-which is a well-accepted view as one of the unique
Autor:
L Rodrigo Rosas-Becerra, Nelly Selem-Mojica, Robert Jedrzejczak, Natalia Maltseva, Karolina Michalska, Andrzej Joachimiak, Deborah T. Hung, Francisco Barona-Gómez, Samantha Wellington
Publikováno v:
Protein Science : A Publication of the Protein Society
Intracellular growth and pathogenesis of Chlamydia species is controlled by the availability of tryptophan, yet the complete biosynthetic pathway for l‐Trp is absent among members of the genus. Some representatives, however, preserve genes encoding