Discovery, Synthesis, and Pharmacological Evaluation of Spiropiperidine Hydroxamic Acid Based Derivatives as Structurally Novel Histone Deacetylase (HDAC) Inhibitors

Autor: Varasi, M, Thaler, F, Abate, A, Bigogno, C, Boggio, R, Carenzi, G, Cataudella, T, DAL ZUFFO, R, Fulco, Mc, Rozio, Mg, Mai, Antonello, Dondio, G, Minucci, S, Mercurio, C.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3686::99c6ab6b2d224a73b79bc7704ef4b544
http://hdl.handle.net/11573/379616

Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands

Autor: Antonio Massa, Rosanna Filosa, Roberto Pellicciari, Christian Thomsen, Paolo De Caprariis, Antonella Peduto, Claus Tornby Christoffersen, Nicola Giacchè, Maura Marinozzi, Antonio Macchiarulo, M. Carmela Fulco

A novel series of bicyclo[1.1.1] pentane-based x-acidic amino acids, including (2S)- and (2R)-3-(3'-carboxybicyclo[1.1.1] pentyl) alanines (8 and 9), (2S)- and (2R)- 2-(30-carboxymethylbicyclo[1.1.1] pentyl) glycines (10 and 11), and (2S)- and (2R)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc9a1e8e26fbfd9ffbe57307cf0b5c9
http://hdl.handle.net/11391/151472

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

Autor: Thaler F; Genextra Group, Congenia Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy; Drug Discovery Program, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy. Electronic address: florian.thaler@ieo.eu., Moretti L; Drug Discovery Program, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy., Amici R; Genextra Group, Congenia Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy; Drug Discovery Program, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy., Abate A; Genextra Group, DAC Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy; Drug Discovery Program, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy., Colombo A; NiKem Research Srl, Via Zambeletti 25, 20021 Baranzate, MI, Italy., Carenzi G; Genextra Group, DAC Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy; Drug Discovery Program, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy., Fulco MC; Genextra Group, DAC Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy; Drug Discovery Program, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy., Boggio R; Genextra Group, Congenia Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy., Dondio G; NiKem Research Srl, Via Zambeletti 25, 20021 Baranzate, MI, Italy., Gagliardi S; NiKem Research Srl, Via Zambeletti 25, 20021 Baranzate, MI, Italy., Minucci S; European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy; University of Milan, University of Milan, Via Celoria 26, 20133 Milan, Italy., Sartori L; Genextra Group, DAC Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy; Drug Discovery Program, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy., Varasi M; Genextra Group, DAC Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy; Drug Discovery Program, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy., Mercurio C; Genextra Group, DAC Srl, Genextra Group, Via Adamello 16, 20139 Milan, Italy. Electronic address: ciro.mercurio@ieo.eu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2016 Jan 27; Vol. 108, pp. 53-67. Date of Electronic Publication: 2015 Nov 11.

Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.

Autor: Pellicciari R; Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo, 1- 06123 Perugia, Italy. rp@unipg.it, Marinozzi M, Macchiarulo A, Fulco MC, Gafarova J, Serpi M, Giorgi G, Nielsen S, Thomsen C

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2007 Sep 20; Vol. 50 (19), pp. 4630-41. Date of Electronic Publication: 2007 Aug 29.