Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Fukuichi Ohsawa"'
Autor:
Takashi Watanabe, Hideo Kitagawa, Jun Saito, Yasuo Takeuchi, Sho Takahata, Tomohiro Ozawa, Fukuichi Ohsawa, Mototsugu Yamada, Maiko Iida
Publikováno v:
Protein Science. 17:691-699
Enoyl-acyl carrier protein (ACP) reductases are critical for bacterial type II fatty acid biosynthesis and thus are attractive targets for developing novel antibiotics. We determined the crystal structure of enoyl-ACP reductase (FabK) from Streptococ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16fada20c9fff8f233a4605e9a2dbeb
https://doi.org/10.1110/ps.073288808
https://doi.org/10.1110/ps.073288808
Autor:
Mototsugu Yamada, Nobuyoshi Baba, Jun Saito, Takako Miyara, Takashi Watanabe, Yasuo Takeuchi, Fukuichi Ohsawa
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:3902-3907
Cefditoren is the active form of cefditoren pivoxil, an oral cephalosporin antibiotic used for the treatment of respiratory tract infections and otitis media caused by bacteria such as Streptococcus pneumoniae , Haemophilus influenzae , Streptococcus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a8eaaf4bdcf9ec13b1685ad3b3996b
https://doi.org/10.1128/aac.00743-07
https://doi.org/10.1128/aac.00743-07
Autor:
Kaoru Takanaka, Yukiharu Nakayama, Keiichi Ida, Shunichi Kametani, Toshio Inoda, Takashi Izumi, Masato Tani, Kouichi Nakamura, Eiji Kashiyama, Shigemichi Morita, Fukuichi Ohsawa, Shuichi Sakai, Meguru Achira, Akira Kagayama, Satoru Asahi, Nobuo Osawa, Jun Morita, Yoshinobu Yoshimura, Kimitoshi Saito, Yoshiaki Terauchi, Takuro Niwa, Osamu Takenaka, Takanori Hashizume, Kiyoshi Noguchi, Toshifumi Shiraga, Yasuhiro Nakai, Satoshi Omori, Akinori Aoyama, Takashi Kuwabara, Hiroyuki Kawai, Akio Nakamura, Toshiyuki Kume, Sekio Nagayama, Masahiko Iwasaki, Takuya Yoshimura, Mitsuaki Takeuchi, Hideki Nakamura, Takashi Kawashiro, Takeshi Nakabayashi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 19:444-452
As a part of the studies conducted by the Pharma SNPs Consortium (PSC), the enzyme activities of CYP1A2, CYP2A6 and CYP2B6 variants with altered amino acids as a result of single nucleotide polymorphisms (SNPs) found among the Japanese population wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8022493d1f872622e180d5d0b15d9e
https://doi.org/10.2133/dmpk.19.444
https://doi.org/10.2133/dmpk.19.444
Publikováno v:
Japanese Journal of Pharmacology. 77:147-154
Several previous studies have demonstrated that the phosphodiesterase 4 selective inhibitor rolipram affects cellular function at a much lower concentration than the reported Ki value for phosphodiesterase 4 inhibition. In this study, we examined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930073595b7a13a6dde390fbaa28084e
https://doi.org/10.1254/jjp.77.147
https://doi.org/10.1254/jjp.77.147
Autor:
Shuichi Gomi, Yasuo Takeuchi, Nobuyoshi Baba, Takashi Watanabe, Mototsugu Yamada, Fukuichi Ohsawa
Biapenem is a parenteral carbapenem antibiotic that exhibits wide-ranging antibacterial activity, remarkable chemical stability, and extensive stability against human renal dehydropeptidase-I. Tebipenem is the active form of tebipenem pivoxil, a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc65b2ad9d0e633bc0471827238f3f41
https://europepmc.org/articles/PMC2415762/
https://europepmc.org/articles/PMC2415762/
Autor:
Makoto Suzuki, Takako Miyara, Masaharu Sugai, Kenji Asai, Yuji Tabata, Kozo Aoki, Jiro Tanaka, Fukuichi Ohsawa, Yuko Nakatani, Nobukazu Kakui, Hiroshi Kitaguchi, Naomi Masuda, Naoyuki Nishikawa
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 317(2)
We evaluated the pharmacological profiles of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel tetrahydrocarbazole derivative as a neuropeptide Y (NPY) Y5 receptor antagonist. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37e4a5159b45af10d5b732876eae880
https://pubmed.ncbi.nlm.nih.gov/16436501
https://pubmed.ncbi.nlm.nih.gov/16436501
Autor:
Takahisa Suzuki, Yumi Osaki, Takashi Ida, Yumiko Sanbongi, Midori Ishikawa, Minoru Yonezawa, Hiroshi Kataoka, Fukuichi Ohsawa, Kumiko Kondo
Publikováno v:
Antimicrobial agents and chemotherapy. 48(6)
All six penicillin-binding protein (PBP) genes, namely, pbp1a , pbp1b , pbp2a , pbp2b , pbp2x , and pbp3 , of 40 Streptococcus pneumoniae clinical isolates, including penicillin-resistant S. pneumoniae isolates collected in Japan, were completely seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8de9a804e3c782769d958413c0186b
https://pubmed.ncbi.nlm.nih.gov/15155228
https://pubmed.ncbi.nlm.nih.gov/15155228
Autor:
Fujio Isono, Hans Rudolf Widmer, Gregory L. Bennett, Millicent M. Dugich-Djordjevic, Fukuichi Ohsawa, Timothy L. Denton, Franz Hefti, Christine Peterson
Publikováno v:
The European journal of neuroscience. 7(9)
A purified polyclonal antibody preparation was made against recombinant brain-derived neurotrophic factor (BDNF) in guinea pig and characterized for use in immunoassays and immunohistochemistry. The anti-BDNF antibodies specifically recognized BDNF i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1ca0240b9752bcdbeee9a908f72cf4
https://pubmed.ncbi.nlm.nih.gov/8528456
https://pubmed.ncbi.nlm.nih.gov/8528456
Autor:
T. Okazaki, Millicent M. Dugich-Djordjevic, Fukuichi Ohsawa, Jonathan R. Day, Franz Hefti, Klaus D. Beck, Nozomu Mori
Publikováno v:
Neuroscience. 66(4)
Ribonuclease protection analysis and quantitative in situ hybridization histochemistry were used to investigate the coordination and regional expression of catalytic and non-catalytic trk B messenger RNAs in the adult rat hippocampus following system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193c8dcf096e0062a263f95adf82756a
https://pubmed.ncbi.nlm.nih.gov/7651614
https://pubmed.ncbi.nlm.nih.gov/7651614