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Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo

Autor: Minegishi, Genki, Kazuki, Yasuhiro, Yamasaki, Yuki, Fuka Okuya, Akita, Hidetaka, Oshimura, Mitsuo, Kobayashi, Kaoru

1. To investigate cytochrome P450 3A (CYP3A)-mediated metabolism in vivo, plasma concentrations of triazolam (TRZ) are often monitored as a CYP3A marker in CYP3A-humanised mice. However, it has not been determined whether plasma concentrations of TRZ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d08bfaf116e49f5559b6e8c8a54c7e4

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Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans

Autor: Shoko Takehara, Kaoru Kobayashi, Kanako Kazuki, Fuka Okuya, Sumio Ohtsuki, Yuki Yamasaki, Genki Minegishi, Satoshi Abe, Kan Chiba, Hidetaka Akita, Yasuhiro Kazuki, Mitsuo Oshimura, Seiryo Ogata, Naoyo Kajitani, Tatsuki Uemura, Shingo Ito

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 46(11)

P-glycoprotein (P-gp), encoded by the MDR1 gene in humans and by the Mdr1a/1b genes in rodents, is expressed in numerous tissues and performs as an efflux pump to limit the distribution and absorption of many drugs. Owing to species differences of P-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5b7b5568f09f527112e1b94827704e
https://pubmed.ncbi.nlm.nih.gov/29777024

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