Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators

Autor: Shoda, Takuji, Kato, Masashi, Harada, Rintaro, Fujisato, Takuma, Okuhira, Keiichiro, Demizu, Yosuke, Inoue, Hideshi, Naito, Mikihiko, Kurihara, Masaaki

Publikováno v: In Bioorganic & Medicinal Chemistry 1 July 2015 23(13):3091-3096

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Design and synthesis of novel selective estrogen receptor degradation inducers based on the diphenylheptane skeleton.

Autor: Misawa T; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Fujisato T; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Kanda Y; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Ohoka N; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Shoda T; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Yorioka M; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Makishima M; Nihon University Itabashi , Tokyo , 173-8610 , Japan., Sekino Y; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Naito M; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Demizu Y; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp., Kurihara M; National Institute of Health Sciences Setagaya , Tokyo , 158-8501 , Japan . Email: misawa@nihs.go.jp ; Email: masaaki@nihs.go.jp.

Publikováno v: MedChemComm [Medchemcomm] 2016 Dec 08; Vol. 8 (1), pp. 239-246. Date of Electronic Publication: 2016 Dec 08 (Print Publication: 2017).