Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Fujio Asanuma"'
Autor:
Akira Kugimiya, Fujio Asanuma, William M. Abraham, Go Takahashi, Shingo Sakamoto, Goro Kuwajima, Masashi Deguchi, Michitaka Shichijo, Maki Hattori, Akinori Arimura, Yasuhiko Tomita, Noriko Suzuki
Publikováno v:
European Journal of Pharmacology. 765:15-23
Prostaglandin (PG) D2 elicits responses through either the DP1 and/or DP2 receptor. Experimental evidence suggests that stimulation of the DP1 receptor contributes to allergic responses, such that antagonists are considered to be directed therapies f
Autor:
Fujio Asanuma, Hirotaka Kumada, Yoko Hurue, Masako Sugiura, Yuichi Inagaki, Susumu Mitsutake, Urara Yokose, Masahiko Soga, Takafumi Kohama, Yasuyuki Igarashi, Masashi Deguchi, Morio Nagira, Tomomi Date
Publikováno v:
Prostaglandins & Other Lipid Mediators. 93:109-112
Ceramide kinase (CerK) catalyzes the conversion of ceramide to ceramide 1-phosphate (C1P). We previously revealed that CerK is involved in the activation of mast cells. In this study, we performed an advanced investigation into the role of CerK on th
Autor:
Masashi Deguchi, Michitaka Shichijo, Fujio Asanuma, Kiyoshi Yasui, Yosuke Hirano, Akinori Arimura
Publikováno v:
European Journal of Pharmacology. 578:286-291
We examined the role of prostanoid DP receptor in nasal blockage in an experimental allergic rhinitis model in guinea pigs. Local inhalation of prostaglandin D(2) (PGD(2)) to the nasal cavity resulted in an increase in intranasal pressure in guinea p
Autor:
Susumu Mitsumori, Masanao Inagaki, Fujio Asanuma, Hiroshi Hashizume, Toshihiko Okada, Junji Kishino, Kiyoshi Yasui, Tatsuo Tsuri, Yoshiharu Hiramatsu, Akinori Arimura, Mitsuaki Ohtani, Tsunetoshi Honma
Publikováno v:
Journal of Medicinal Chemistry. 40:3504-3507
Publikováno v:
International Archives of Allergy and Immunology. 112:400-405
To estimate the involvement of thromboxane (Tx) A2 in the onset of nasal blockage, we examined the effect of the selective TxA2 receptor antagonist, S-1452, as well as an H1-antihistamine, diphenhydramine, on the antigen-induced increase in intranasa
Autor:
María Isabel Esteban, Vincenzo Izzo, Luis Caraballo, Masatsugu Kurokawa, Akemi Morita, Tadao Kasahara, Mina Ike, Miki Nyui, Dilia Mercado, Qunwei Zhang, Tamás Gesztesi, Silvia Jiménez, Takako Matsuoka, Takako Oshiro, Thomas Baumruker, Masayuki Ando, A. Eshel, Asil Avjiouglu, Yukinori Kusaka, Y. Waisel, Yasunori Kakuta, Yasuharu Nishimura, Kazuhiro Sato, Pilar García-Ortega, Hideo Kikkawa, Borja Bartolomé, Paolo Colombo, Kana Ueno, Giovanni Locorotondo, Katsuo Ikezawa, B. Grubeck-Loebenstein, Tadashi Ariga, Shigeki Matsubara, Robert N. Pike, Nikolaus Romani, Manfred Auer, Z. Bodnár, Leonardo Puerta, James Travis, Toshiaki Fushimi, Maria Assunta Costa, Ichiro Kobayashi, Laureano Fernández-Távora, Nobuaki Kawamura, Rossana Porcasi, Sho Matsushita, Hiroshi Okayama, E. Kosman, Roberta Cocchiara, M.M. Steger, Hirotsugu Kohrogi, M. Raulf-Heimsoth, Gunther G. Pendl, Nathalie E. Harrer, Alberto Martínez, Ilona Kaszás, Kenta Kawazu, Werner Thumb, Mitsuru Adachi, Beatrice Thurner, Eva E. Prieschl, Giovanni Duro, Fujio Asanuma, Ricardo Palacios, Nobuhiro Maruyama, Montserrat de Molina, Renata Di Fiore, Dennis A. Bagarozzi, Gen Tamura, Atsushi Tame, M. Saurwein-Teissl, Akinori Arimura, Y. Yanagihara, M. Düser, Yukio Sakiyama, Sanae Shimura, Motohiko Okano, Osamu Kaminuma, János M. Jákó, Jorge Martínez, Beatriz Martínez, Hirofumi Furuta, C. Maczek, A. Flagge, Javier Fernández, David G. Marsh, Ken Tomita, Gerold Schuler, Domenico Geraci, Shin-ichi Konno, Yoshiki Gonokami, Kunio Shirato, Angel Vallverdú, A.B. Czuppon, Kiyoshi Yasui, X. Baur, Yoko Furue, I. Sander
Publikováno v:
International Archives of Allergy and Immunology. 112:I-IV
Autor:
Atsushi Kurosawa, Hiroichi Nagai, Hirokuni Jyoyama, Yoko Matsumoto, Fujio Asanuma, Akinori Arimura
Publikováno v:
European Journal of Pharmacology. 260:201-209
Long-lasting bronchial hyperresponsiveness to i.v. acetylcholine was observed in actively sensitized guinea-pigs after aerosol ovalbumin exposure. The response became significant at 7 h post-challenge and persisted for at least 120 h compared to the
Publikováno v:
British Journal of Pharmacology. 111:339-345
1 IgG1-mediated anaphylactic bronchoconstriction was elicited by intravenous administration of antigen to guinea-pig 2 days after passive sensitization with IgG1-rich serum, and this response was not affected by heating the serum (at 56°C, for 4 h).
Publikováno v:
Drug Development Research. 30:62-71
The thromboxane A, (TXA,) receptor antagonist, S-1452, calcium salt of a sterose- lectively synthesized d-enantiomer of the racemate 5-145, calcium 5(Z)-1 R,2S,3S,4S-7-(3-phenyl- sulfonylaminobicyclo(2.2.1) hept-2-yll-5-heptenoate di hydrate, was exa
Publikováno v:
Drug Development Research. 30:78-82
The thromboxane A2 receptor antagonist S-1452, d-S-145 Ca, calcium 5(Z)-1R,2S,3S,4S-7-[3-phenylsulfonylaminobicyclo[2.2.1]hept-2-yl]-5-heptenoate dihydrate, is a partial agonist and transiently alters platelet shape and smooth muscle contraction in v