Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Fujiko Takamura"'
Autor:
Takeru Yamaguchi, Nozomu Kato, Rieko Goto, Hisao Shimizu, Ryoya Goda, Yoshiaki Ohtsu, Masahiro Utoh, Masaki Hoshino, Noriko Katori, Fujiko Takamura, Masanari Mabuchi, Akiko Ishii-Watabe, Noritaka Hashii
Publikováno v:
CHROMATOGRAPHY. 39:7-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbefd9b3d1151f15b6671c544f0c49aa
https://doi.org/10.15583/jpchrom.2017.018
https://doi.org/10.15583/jpchrom.2017.018
Autor:
Fujiko Takamura, Erik E. Karrer, Yasuyuki Higashi, Steven J. Chapin, Margaret Neighbors, Sridhar Viswanathan, Hidekazu Mizuhara, Shinsuke Oshima, Yasutomo Fujii, Bruce H. Devens
Publikováno v:
International Immunopharmacology. 40:310-317
The CTLA4-Ig fusion proteins abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2) costimulatory ligands and are clinically proven immunosuppressants used for rheumatoid arthritis and renal transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ff00ad001bd419bd264871d2b736f8
https://doi.org/10.1016/j.intimp.2016.09.009
https://doi.org/10.1016/j.intimp.2016.09.009
Autor:
Yasutomo Fujii, Takahisa Noto, Yasuyuki Higashi, Steven J. Chapin, Margaret Neighbors, Yuka Kawato, Shinsuke Oshima, B. Devens, Masashi Maeda, Sridhar Viswanathan, Susumu Tsujimoto, Jun Hirose, Hidehiko Fukahori, Fujiko Takamura, Erik E. Karrer, Koji Nakamura, Takanori Marui
Publikováno v:
Transplantation. 100(12)
Background Blockade of CD28-mediated T cell costimulation by a modified cytotoxic T lymphocyte-associated antigen 4 (CTLA4-Ig), belatacept, is a clinically effective immunosuppressive therapy for the prevention of renal allograft rejection. Use of be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fd00138a6907188d0b97a98d07cdb8
https://pubmed.ncbi.nlm.nih.gov/27861289
https://pubmed.ncbi.nlm.nih.gov/27861289
Autor:
Shigeyuki Terashita, Fumihiro Nakamori, Fujiko Takamura, Hiroya Miura, Hidetsugu Murai, Toshio Teramura, Yoichi Naritomi, Masako Furutani
Publikováno v:
Drug Metabolism and Pharmacokinetics. 26:465-473
A method for quantitatively predicting the hepatic clearance of drugs by UDP-glucuronosyltransferases (UGTs) from in vitro data has not yet been established. We examined the relationship between in vitro and in vivo intrinsic clearance by rat hepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3eb38abd5b7b9dde89ce2b308670508
https://doi.org/10.2133/dmpk.dmpk-11-rg-018
https://doi.org/10.2133/dmpk.dmpk-11-rg-018
Autor:
Kazunori Arai, Mako Numazaki, Shigetada Furukawa, Emiko Imamura, Satoshi Kubo, Hiroshi Suzuki, Kaori Hanaoka, Fujiko Takamura, Masashi Maeda, Tetsu Saito
Publikováno v:
Journal of Allergy and Clinical Immunology. 141:AB13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4d92cec66b11de9ca4ed178dc347b78
https://doi.org/10.1016/j.jaci.2017.12.042
https://doi.org/10.1016/j.jaci.2017.12.042
Autor:
Kenichi Washizuka, Yasuhiro Matsumura, Yasuyo Tomishima, Keiko Nakano, Naoko Unami, Fujiko Takamura, Takanobu Araki, Shigeo Matsui, Minoru Sakurai, Masashi Imanishi, Takao Yamamoto, Kaori Hamada, Kouji Hattori, Hitoshi Hamashima, Nobuhiro Yamamoto, Emiko Imamura, Hirofumi Ishikawa, Koji Ueshima, Yutaka Nakajima, Susumu Toda, Shinji Itou
Publikováno v:
Journal of Medicinal Chemistry. 52:3063-3072
As an extension of research conducted on beta(3)-adrenergic receptor agonists as potential drugs for treating overactive bladder (OAB), novel series containing an acylsulfonamide moiety instead of the carboxylic acid moiety were evaluated. These comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db696b5f389955fb00201a425aef2632
https://doi.org/10.1021/jm9000709
https://doi.org/10.1021/jm9000709
Autor:
Masashi, Imanishi, Yasuyo, Tomishima, Shinji, Itou, Hitoshi, Hamashima, Yutaka, Nakajima, Kenichi, Washizuka, Minoru, Sakurai, Shigeo, Matsui, Emiko, Imamura, Koji, Ueshima, Takao, Yamamoto, Nobuhiro, Yamamoto, Hirofumi, Ishikawa, Keiko, Nakano, Naoko, Unami, Kaori, Hamada, Yasuhiro, Matsumura, Fujiko, Takamura, Kouji, Hattori
Publikováno v:
Journal of Medicinal Chemistry. 51:1925-1944
A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human beta 3 adrenergic receptor (beta 3-AR) agonists with good oral bioavailability and long plasma half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3df2218288fe87564bacbf9f841e0ed
https://doi.org/10.1021/jm701324c
https://doi.org/10.1021/jm701324c
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5
Autor:
Jiro Seki, Kiyoshi Taniguchi, Akira Tanaka, Kouji Hattori, Hisashi Takasugi, Fujiko Takamura, Mie Nishio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4475-4478
A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721d7bc78a2411b0ca63044f84db057c
https://doi.org/10.1016/j.bmcl.2006.06.033
https://doi.org/10.1016/j.bmcl.2006.06.033
Autor:
Kouji, Hattori, Fujiko, Takamura, Akira, Tanaka, Hisashi, Takasugi, Kiyoshi, Taniguchi, Mie, Nishio, Satoshi, Koyama, Jiro, Seki, Kazuo, Sakane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3284-3287
A metabolism study of FR181157 (1) led to the discovery of new oxazole derivatives as active metabolites. The metabolite 6 with an epoxy ring exhibited high anti-aggregative potency with an IC(50) of 5.8 nM and potent binding affinity for the human r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc565e53a9c03d9516b3b2486ac467b
https://doi.org/10.1016/j.bmcl.2005.04.076
https://doi.org/10.1016/j.bmcl.2005.04.076
Autor:
Kazuo Sakane, Satoru Kuroda, Hiromichi Itani, Atsushi Akahane, Fujiko Takamura, Yasuyo Tomishima, Yoshiyuki Tenda
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 49:988-998
A novel series of 3-(2-substituted-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridines (5—38) were synthesized and evaluated for their in vitro adenosine A1 and A2A receptor binding activities, and in vitro metabolism by rat liver in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a50230e34ef837d9d0c35589252c6b9c
https://doi.org/10.1248/cpb.49.988
https://doi.org/10.1248/cpb.49.988