Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Fujiko Duke"'
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sen
Externí odkaz:
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Autor:
Chandra Sekhar Pedamallu, Ami S. Bhatt, Susan Bullman, Sharyle Fowler, Samuel S. Freeman, Jacqueline Durand, Joonil Jung, Fujiko Duke, Veronica Manzo, Diana Cai, Ashwin Ananthakrishnan, Akinyemi I. Ojesina, Aruna Ramachandran, Dirk Gevers, Ramnik J. Xavier, Atul K. Bhan, Matthew Meyerson, Vijay Yajnik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 5, Pp 563-566.e5 (2016)
Background & Aims: Microbial dysbiosis and aberrant hostâmicrobe interactions in the gut are believed to contribute to the development and progression of Crohnâs disease (CD). Microbiome studies in CD typically have focused on microbiota in feces o
Externí odkaz:
https://doaj.org/article/b26f792cc6da438d895f3c57043e9912
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Natasha Rekhtman, Athea Vichas, Robert K. Bradley, Jacqueline Watson, John K. Lee, Austin M. Gabel, Marina K. Baine, Amanda K. Riley, Shriya Kamlapurkar, Federica Piccioni, James D. Thomas, Iris Fung, Naomi T. Nkinsi, Emily M. Hatch, Jennifer Chen, Marc Ladanyi, Matthew G. Rees, Fujiko Duke, April Lo, Phoebe C. R. Parrish, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13965f9f552d8b88b893eeabc031c85b
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Autor:
Ashton C. Berger, Matthew Meyerson, David J. Kwiatkowski, Craig A. Strathdee, Andrew D. Cherniack, Fujiko Duke, Laura Furst, Jonathan T. Goldstein, Juliann Shih
Publikováno v:
Cancer Research. 77:6987-6998
The PPARG gene encoding the nuclear receptor PPARγ is activated in bladder cancer, either directly by gene amplification or mutation, or indirectly by mutation of the RXRA gene, which encodes the heterodimeric partner of PPARγ. Here, we show that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719d240bf76e8cbd53456428adb65bab
https://doi.org/10.1158/0008-5472.can-17-1701
https://doi.org/10.1158/0008-5472.can-17-1701
Autor:
Olga Pozdnyakova, Fujiko Duke, Nicole R. LeBoeuf, Betty Rouaisnel, Ben W. Humrighouse, Julie-Aurore Losman, Ryan Sells, Pavan K. Bendapudi, Arturo P. Saavedra, Meaghan E. Colling, Kathryn E. Stephenson, Alissa Robbins, John R. McQuiston, Ami S. Bhatt
Purpura fulminans (PF) is a rare life-threatening complication of bacterial sepsis that is characterized by a highly thrombotic subtype of disseminated intravascular coagulation (DIC) and mortality of up to 80%.[1][1] Patients with PF develop a sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7964c2842d965302e11d5fb5efab6dea
https://europepmc.org/articles/PMC6234356/
https://europepmc.org/articles/PMC6234356/
Autor:
Naiyer A. Rizvi, Thomas Boucher, Elie Fadel, Christine D. Palmer, Andrew Clark, Matthew J. Davis, Vladimir Makarov, John Hrom, Mark G. Frattini, Niki Karachaliou, Timothy A. Chan, Michele Busby, Kamilah Caldwell, Mojca Skoberne, Jennifer Busby, Karin Choquette, Ian Anderson, Joshua M. Francis, Jesse Abhyankar, Meghan G. Hart, Vincent Thomas de Montpréville, Olaf Mercier, Raphael Rousseau, Karin Jooss, Paolo Bironzo, Aaron Yang, Alexander I. Spira, Rafael Rosell, Tyler Murphy, Fujiko Duke, Roman Yelensky, Noelle C Ojo, Lauren Young, Chainarong Limvarapuss, Giorgio V. Scagliotti, Nashat Gabrail, Brendan Bulik-Sullivan, Cynthia Voong, Silvia Novello
Publikováno v:
Nature biotechnology.
Neoantigens, which are expressed on tumor cells, are one of the main targets of an effective antitumor T-cell response. Cancer immunotherapies to target neoantigens are of growing interest and are in early human trials, but methods to identify neoant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2895fb09c854c605a8f4ae6a758fcc
https://pubmed.ncbi.nlm.nih.gov/30556813
https://pubmed.ncbi.nlm.nih.gov/30556813
Autor:
Natalia P. Bosak, Mohammed Amin Koshnevisan, Cailu Lin, Danielle R. Reed, Charles J. Arayata, Michael Marquis, Maria L. Theodorides, Alexander A. Bachmanov, Mauricio Avigdor, Theodore M. Nelson, Brad D. Fesi, Lauren Shaw, Anna Lysenko, Amanda H. McDaniel, Fujiko Duke
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 29(5-6)
To fine map a mouse QTL for lean body mass (Burly1), we used information from intercross, backcross, consomic, and congenic mice derived from the C57BL/6ByJ (host) and 129P3/J (donor) strains. The results from these mapping populations were concordan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd9e6879e1a9190c563e078511871d3
https://pubmed.ncbi.nlm.nih.gov/29737391
https://pubmed.ncbi.nlm.nih.gov/29737391
Autor:
Cailu Lin, Mohammed Amin Koshnevisan, Theodore M. Nelson, Maria L. Theodorides, Danielle R. Reed, Mauricio Avigdor, Michael Marquis, Charles J. Arayata, Fujiko Duke, Brad D. Fesi, Natalia P. Bosak, Anna Lysenko, Lauren Shaw, Alexander A. Bachmanov, Amanda H. McDaniel
Our goal was to fine map a mouse QTL for lean body mass (Burly1) using information from several populations including newly created congenic mice derived from the B6 (host) and 129 (donor) strains. The results from each mapping population were concor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7ab0d9b7658ad79a8c5dfcc2f87d4f
Autor:
Cailu Lin, Anna Lysenko, Michael Marquis, Natalia P. Bosak, Brad D. Fesi, Theodore M. Nelson, Charles J. Arayata, Fujiko Duke, Amanda H. McDaniel, Mohammed Amin Koshnevisan, Danielle R. Reed, Lauren Shaw, Alexander A. Bachmanov, Maria L. Theodorides, Mauricio Avigdor
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188972 (2017)
PLoS ONE
PLoS ONE
An average mouse in midlife weighs between 25 and 30 g, with about a gram of tissue in the largest adipose depot (gonadal), and the weight of this depot differs between inbred strains. Specifically, C57BL/6ByJ mice have heavier gonadal depots on aver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3a592a5037267c756895203c0b8d19
https://doi.org/10.1101/171777
https://doi.org/10.1101/171777
Autor:
Hui Jiang, Xiao Chang, Jianguo Zhang, Chung Wen Yu, Liang-Dar Hwang, Brendan J. Keating, George Preti, Danielle R. Reed, Yiran Guo, Paul V. Fennessey, Jason Eades, Yulan Chen, Fujiko Duke, Hakon Hakonarson, Corrine Mansfield, Alexis Burdick-Will, Steven Fakharzadeh, Jiankang Li
Publikováno v:
BMC Medical Genetics
Background Trimethylaminuria (TMAU) is a genetic disorder whereby people cannot convert trimethylamine (TMA) to its oxidized form (TMAO), a process that requires the liver enzyme FMO3. Loss-of-function variants in the FMO3 gene are a known cause of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11bf9460874702708aab2ad1a29fa32
https://doi.org/10.1186/s12881-017-0369-8
https://doi.org/10.1186/s12881-017-0369-8