Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Fujian Wu"'
Autor:
Lei Tian, Tianwei Guo, Fujian Wu, Rui Bai, Sinan Ai, Hongyue Wang, Yuanxiu Song, Min Zhu, Youxu Jiang, Shuhong Ma, Xiaofeng Zhuang, Shuzhen Guo
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Pseudoenzymes, catalytically deficient variants of active enzymes, have a wide range of regulatory functions. ADP-ribosylhydrolase-like 1 (ADPRHL1), a pseudoenzyme belonging to a small group of ADP-ribosylhydrolase enzymes that la
Externí odkaz:
https://doaj.org/article/9a4e35e903514e36a6e5d60d17ef4ae4
Publikováno v:
Heliyon, Vol 9, Iss 9, Pp e19938- (2023)
The use of human cardiac organoids (hCOs) as 3D in vitro models for cardiovascular research has shown great promise. Human pluripotent stem cells (hPSCs) have proven to be a potent source for engineering hCOs. However, various protocols for generatin
Externí odkaz:
https://doaj.org/article/e77f743197254047a16ebaaad5d1a874
Autor:
Yun Chang, Ya-nan Li, Rui Bai, Fujian Wu, Shuhong Ma, Amina Saleem, Siyao Zhang, Youxu Jiang, Tao Dong, Tianwei Guo, Chengwen Hang, Wen-jing Lu, Hongfeng Jiang, Feng Lan
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Background Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclea
Externí odkaz:
https://doaj.org/article/f2c79cbe72364bf0a1cfbd96a93f4ff5
Establishment of human embryonic stem cell WAe009-A-88 carrying a long QT syndrome mutation in KCNH2
Publikováno v:
Stem Cell Research, Vol 62, Iss , Pp 102795- (2022)
Long-QT syndrome type 2 (LQT2) is a life-threatening Mendelian disease caused by genetic variants in KCNH2. Herein, we generated a human embryonic stem cell line (WAe009-A-88) carrying a LQT2 related mutation in KCNH2, c.1720 A>G. The WAe009-A-88 lin
Externí odkaz:
https://doaj.org/article/99ad36746a444d5f8ea3b9fe5b03abf2
Autor:
Rui Bai, Yun Chang, Amina Saleem, Fujian Wu, Lei Tian, Siyao Zhang, Ya’nan Li, Shuhong Ma, Tao Dong, Tianwei Guo, Youxu Jiang, Yi You, Wen-Jing Lu, Hong Feng Jiang, Feng Lan
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Introduction Spinal cord injury (SCI) is a neurological, medically incurable disorder. Human pluripotent stem cells (hPSCs) have the potential to generate neural stem/progenitor cells (NS/PCs), which hold promise in the treatment of SCI by t
Externí odkaz:
https://doaj.org/article/22e18ce2d8c946f593a66ae5a6ae78c0
Establishment of human embryonic stem cell WAe009-A-74 carrying a Long QT syndrome mutation in KCNH2
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102725- (2022)
Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear. Herein, we have g
Externí odkaz:
https://doaj.org/article/c632d5caee684a63b291fa102ad123c2
Autor:
Bei Wang, Mengting Xu, Miaomiao Li, Fujian Wu, Shijun Hu, Xiangbo Chen, Liqun Zhao, Zheyong Huang, Feng Lan, Dong Liu, Yongming Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 19, Iss , Pp 1299-1308 (2020)
Induction of endogenous cardiomyocyte (CM) proliferation is one of the key strategies for heart regeneration. Increasing evidence points to the potential role of microRNAs (miRNAs) in the regulation of CM proliferation. Here, we used human embryonic
Externí odkaz:
https://doaj.org/article/c7106776052a413892ab0bc26c314753
Autor:
Min Zhu, Yangong Liu, Yuanxiu Song, Shiqin Zhang, Chengwen Hang, Fujian Wu, Xianjuan Lin, Zenghui Huang, Feng Lan, Ming Xu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Cyclophosphamide (CYP)-induced cardiotoxicity is a common side effect of cancer treatment. Although it has received significant attention, the related mechanisms of CYP-induced cardiotoxicity remain largely unknown. In this study, we used cell and an
Externí odkaz:
https://doaj.org/article/e33b2b794dc84309859ac57733476427
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102467- (2021)
As a member of the voltage-gated potassium ion channels, KCNQ1 plays an important role in heart physiological functions. Numerous mutations in KCNQ1 were identified as primary causes to hereditary long-QT syndrome. To further study the role of KCNQ1
Externí odkaz:
https://doaj.org/article/223042861e414958a62391de8844f6f0
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102481- (2021)
X-linked Alport syndrome (XLAS) is the second most common inherited kidney disease which pathogenic variants related to a mutation in the COL4A5 gene encoding the type IV collagen α5 chain. Here, we have generated a COL4A5 heterozygous mutant human
Externí odkaz:
https://doaj.org/article/e22c43cd9ec241a1b97067dd5e068e3b