Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma.

Autor: Sharma A; Genome Institute of Singapore, A(∗)STAR, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore. Electronic address: sharmaa@gis.a-star.edu.sg., Seow JJW; Genome Institute of Singapore, A(∗)STAR, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore., Dutertre CA; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore; Program in Emerging Infectious Disease, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore., Pai R; Genome Institute of Singapore, A(∗)STAR, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore., Blériot C; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore., Mishra A; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore., Wong RMM; Genome Institute of Singapore, A(∗)STAR, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore., Singh GSN; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore., Sudhagar S; Genome Institute of Singapore, A(∗)STAR, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore., Khalilnezhad S; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore., Erdal S; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore., Teo HM; Genome Institute of Singapore, A(∗)STAR, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore., Khalilnezhad A; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore., Chakarov S; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore., Lim TKH; Department of Pathology, Singapore General Hospital, Singapore 169608, Singapore., Fui ACY; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Chieh AKW; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, National University of Hospital, Singapore 119074, Singapore., Chung CP; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Bonney GK; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, National University of Hospital, Singapore 119074, Singapore., Goh BK; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Chan JKY; Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore 229899, Singapore; Experimental Fetal Medicine Group, Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, NUS, Singapore 117597, Singapore; Academic Clinical Program in Obstetrics and Gynaecology, Duke-NUS Medical School, Singapore 169857, Singapore., Chow PKH; Division of Surgery and Surgical Oncology, National Cancer Centre, Singapore 169610, Singapore; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore 169857, Singapore. Electronic address: pierce.chow.k.h@singhealth.com.sg., Ginhoux F; Singapore Immunology Network (SIgN), A(∗)STAR, 8A Biomedical Grove, Immunos Building, Level 3 and 4, Singapore 138648, Singapore; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore 169856, Singapore. Electronic address: florent_ginhoux@immunol.a-star.edu.sg., DasGupta R; Genome Institute of Singapore, A(∗)STAR, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore. Electronic address: dasguptar@gis.a-star.edu.sg.

Publikováno v: Cell [Cell] 2020 Oct 15; Vol. 183 (2), pp. 377-394.e21. Date of Electronic Publication: 2020 Sep 24.

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.

Autor: Simoni Y; Agency for Science, Technology and Research (A(∗)STAR), Singapore Immunology Network (SIgN), 138648 Singapore. Electronic address: yannick_simoni@immunol.a-star.edu.sg., Fehlings M; Agency for Science, Technology and Research (A(∗)STAR), Singapore Immunology Network (SIgN), 138648 Singapore., Kløverpris HN; Africa Health Research Institute (AHRI), 4001 Durban, South Africa; Department of Immunology and Microbiology, University of Copenhagen, 1165 Copenhagen, Denmark., McGovern N; Agency for Science, Technology and Research (A(∗)STAR), Singapore Immunology Network (SIgN), 138648 Singapore., Koo SL; Division of Medical Oncology, National Cancer Centre Singapore (NCCS), 169610 Singapore., Loh CY; Agency for Science, Technology and Research (A(∗)STAR), Singapore Immunology Network (SIgN), 138648 Singapore., Lim S; Agency for Science, Technology and Research (A(∗)STAR), Singapore Immunology Network (SIgN), 138648 Singapore., Kurioka A; Peter Medawar Building for Pathogen Research, University of Oxford, OX1 3SY Oxford, UK., Fergusson JR; Peter Medawar Building for Pathogen Research, University of Oxford, OX1 3SY Oxford, UK., Tang CL; Department of Colorectal surgery, Singapore General Hospital, 169856 Singapore., Kam MH; Department of Colorectal surgery, Singapore General Hospital, 169856 Singapore., Dennis K; Department of Colorectal surgery, Singapore General Hospital, 169856 Singapore; Colorectal Practice, Mount Elizabeth Medical Centre, 228510 Singapore., Lim TKH; Department of Anatomical Pathology, Singapore General Hospital, 169608 Singapore., Fui ACY; Department of Hepatopancreatobiliary/Transplant Surgery, Singapore General Hospital, 169608 Singapore., Hoong CW; Department of Upper GI/Bariatric Surgery, Singapore General Hospital, 169608 Singapore., Chan JKY; KK Women's and Children's Hospital, Department of Reproductive Medicine, 229899 Singapore; Duke-NUS Graduate Medical School, 169857 Singapore., Curotto de Lafaille M; Agency for Science, Technology and Research (A(∗)STAR), Singapore Immunology Network (SIgN), 138648 Singapore; New York University School of Medicine, 10012 New york, USA., Narayanan S; Agency for Science, Technology and Research (A(∗)STAR), Institute of Molecular and Cell Biology (IMCB), 138673 Singapore., Baig S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore., Shabeer M; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore., Toh SES; Duke-NUS Graduate Medical School, 169857 Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore; Department of Medicine, National University Health System, 119228 Singapore; Perelman School of Medicine, University of Pennsylvania, 19104 USA., Tan HKK; KK Women's and Children's Hospital, Department of Otolaryngology, 229899 Singapore., Anicete R; KK Women's and Children's Hospital, Department of Otolaryngology, 229899 Singapore., Tan EH; Division of Medical Oncology, National Cancer Centre Singapore (NCCS), 169610 Singapore., Takano A; Department of Anatomical Pathology, Singapore General Hospital, 169608 Singapore., Klenerman P; Peter Medawar Building for Pathogen Research, University of Oxford, OX1 3SY Oxford, UK., Leslie A; Africa Health Research Institute (AHRI), 4001 Durban, South Africa., Tan DSW; Division of Medical Oncology, National Cancer Centre Singapore (NCCS), 169610 Singapore; Agency for Science, Technology and Research (A(∗)STAR), Genome Institute of Singapore (GIS), 138672 Singapore., Tan IB; Division of Medical Oncology, National Cancer Centre Singapore (NCCS), 169610 Singapore; Duke-NUS Graduate Medical School, 169857 Singapore; Agency for Science, Technology and Research (A(∗)STAR), Genome Institute of Singapore (GIS), 138672 Singapore., Ginhoux F; Agency for Science, Technology and Research (A(∗)STAR), Singapore Immunology Network (SIgN), 138648 Singapore., Newell EW; Agency for Science, Technology and Research (A(∗)STAR), Singapore Immunology Network (SIgN), 138648 Singapore. Electronic address: evan_newell@immunol.a-star.edu.sg.

Publikováno v: Immunity [Immunity] 2017 Jan 17; Vol. 46 (1), pp. 148-161. Date of Electronic Publication: 2016 Dec 13.