The immune profile of small HER2-positive breast cancers: a secondary analysis from the APT trial

Autor: Barroso-Sousa, R. ^†, Barry, W.T., Guo, H., Dillon, D., Tan, Y.B., Fuhrman, K., Osmani, W., Getz, A., Baltay, M., Dang, C., Yardley, D., Moy, B., Marcom, P.K., Mittendorf, E.A., Krop, I.E., Winer, E.P., Tolaney, S.M. ^*

Publikováno v: In Annals of Oncology April 2019 30(4):575-581

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.

Autor: Hwang WL; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Jagadeesh KA; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Guo JA; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA., Hoffman HI; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard-MIT MD/PhD and Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA., Yadollahpour P; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Reeves JW; NanoString Technologies, Seattle, WA, USA., Mohan R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Drokhlyansky E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Van Wittenberghe N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ashenberg O; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Farhi SL; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schapiro D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Institute for Computational Biomedicine and Institute of Pathology, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany., Divakar P; NanoString Technologies, Seattle, WA, USA., Miller E; NanoString Technologies, Seattle, WA, USA., Zollinger DR; NanoString Technologies, Seattle, WA, USA., Eng G; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Schenkel JM; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Su J; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Shiau C; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yu P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Freed-Pastor WA; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Abbondanza D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mehta A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gould J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lambden C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Porter CBM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tsankov A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dionne D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waldman J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuoco MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen L; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Delorey T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Phillips D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Barth JL; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kem M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Rodrigues C; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ciprani D; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Roldan J; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zelga P; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jorgji V; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Chen JH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ely Z; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhao D; New York Medical College, Valhalla, NY, USA., Fuhrman K; NanoString Technologies, Seattle, WA, USA., Fropf R; NanoString Technologies, Seattle, WA, USA., Beechem JM; NanoString Technologies, Seattle, WA, USA., Loeffler JS; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ryan DP; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Weekes CD; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ferrone CR; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Qadan M; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Aryee MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jain RK; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Neuberg DS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Wo JY; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hong TS; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Xavier R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aguirre AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Rozenblatt-Rosen O; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Mino-Kenudson M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Castillo CF; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Liss AS; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ting DT; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jacks T; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA. tjacks@mit.edu.; Genentech, South San Francisco, CA, USA. tjacks@mit.edu.

Publikováno v: Nature genetics [Nat Genet] 2022 Aug; Vol. 54 (8), pp. 1178-1191. Date of Electronic Publication: 2022 Jul 28.

Digital quantitative assessment of PD-L1 using digital spatial profiling.

Autor: Gupta S; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Zugazagoitia J; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Martinez-Morilla S; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Fuhrman K; Nanostring Technologies®, Seattle, WA, USA., Rimm DL; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. david.rimm@yale.edu.; Department of Internal Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, USA. david.rimm@yale.edu.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2020 Oct; Vol. 100 (10), pp. 1311-1317. Date of Electronic Publication: 2020 Apr 06.

Po-309 Characterisation of the immune microenvironment of colorectal cancer using a novel high-plex protein analysis technology

Autor: Fuhrman, K., Doug, H., Sarah, C., Chris, M., Yan, L., Sarah, W., Joe, B.

Publikováno v: In ESMO Open 30 June-3 July 2018 3 Supplement 2:A349-A349

Gene expression profiling distinguishes prefibrotic from overtly fibrotic myeloproliferative neoplasms and identifies disease subsets with distinct inflammatory signatures.

Autor: Wong WJ; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Baltay M; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Getz A; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Fuhrman K; Nanostring Technologies Inc., Seattle, Washington, United States of America., Aster JC; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Hasserjian RP; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Pozdnyakova O; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

Publikováno v: PloS one [PLoS One] 2019 May 09; Vol. 14 (5), pp. e0216810. Date of Electronic Publication: 2019 May 09 (Print Publication: 2019).