Towards Explainable End-to-End Prostate Cancer Relapse Prediction from H&E Images Combining Self-Attention Multiple Instance Learning with a Recurrent Neural Network

Autor: Dietrich, Esther, Fuhlert, Patrick, Ernst, Anne, Sauter, Guido, Lennartz, Maximilian, Stiehl, H. Siegfried, Zimmermann, Marina, Bonn, Stefan

Clinical decision support for histopathology image data mainly focuses on strongly supervised annotations, which offers intuitive interpretability, but is bound by expert performance. Here, we propose an explainable cancer relapse prediction network

Externí odkaz: http://arxiv.org/abs/2111.13439

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Robust, credible, and interpretable AI-based histopathological prostate cancer grading.

Autor: Westhaeusser F; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Spearpoint Analytics AB, Stockholm, Sweden., Fuhlert P; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Spearpoint Analytics AB, Stockholm, Sweden., Dietrich E; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lennartz M; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Khatri R; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kaiser N; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Röbeck P; Department of Urology, Uppsala University Hospital, Uppsala, Sweden., Bülow R; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., von Stillfried S; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Witte A; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ladjevardi S; Department of Urology, Uppsala University Hospital, Uppsala, Sweden., Drotte A; Spearpoint Analytics AB, Stockholm, Sweden., Severgardh P; Spearpoint Analytics AB, Stockholm, Sweden., Baumbach J; Institute of Computational Systems Biology, University of Hamburg, Germany., Puelles VG; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Häggman M; Department of Urology, Uppsala University Hospital, Uppsala, Sweden., Brehler M; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Boor P; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Walhagen P; Spearpoint Analytics AB, Stockholm, Sweden., Dragomir A; Department of Pathology, Uppsala University Hospital and Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Busch C; Spearpoint Analytics AB, Stockholm, Sweden.; Department of Urology, Uppsala University Hospital, Uppsala, Sweden., Graefen M; Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Bengtsson E; Spearpoint Analytics AB, Stockholm, Sweden.; Uppsala University, Department of Information Technology, Centre for Image Analysis, Uppsala, Sweden., Sauter G; Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zimmermann M; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bonn S; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Spearpoint Analytics AB, Stockholm, Sweden.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jul 10. Date of Electronic Publication: 2024 Jul 10.