Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Fugaku Aoki"'
Autor:
Yuan Wang, Dai Tsukioka, Shoji Oda, Masataka G. Suzuki, Yutaka Suzuki, Hiroshi Mitani, Fugaku Aoki
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Phosphorylated H2AX, known as γH2AX, forms in response to genotoxic insults in somatic cells. Despite the high abundance of H2AX in zygotes, the level of irradiation-induced γH2AX is low at this stage. Another H2A variant, TH2A, is present
Externí odkaz:
https://doaj.org/article/2136bf7aad0d4dc998d09c8a3c2f7c41
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 3, Pp 197-201 (2024)
In somatic cells, DNA repair is attenuated during mitosis to prevent the formation of anaphase bridges and facilitate the proper segregation of sister chromatids. Irradiation-induced γH2AX foci persist for hours in M phase somatic cells. However, we
Externí odkaz:
https://doaj.org/article/4403876516664913a65a54c4e25e0501
Publikováno v:
The Journal of Reproduction and Development, Vol 69, Iss 3, Pp 178-182 (2023)
Linker histone variants regulate higher-order chromatin structure and various cellular processes. It has been suggested that linker histone variant H1a loosens chromatin structure and activates transcription. However, its role in early mouse developm
Externí odkaz:
https://doaj.org/article/bbda87dfd1a342aabbea24021deed378
Autor:
Fugaku AOKI
Publikováno v:
The Journal of Reproduction and Development, Vol 68, Iss 2, Pp 79-84 (2022)
The zygotic genome is transcriptionally silent immediately after fertilization. In mice, initial activation of the zygotic genome occurs in the middle of the one-cell stage. At the mid-to-late two-cell stage, a burst of gene activation occurs after t
Externí odkaz:
https://doaj.org/article/9163058f97714fa293416f6c9242ff7e
Publikováno v:
Insects, Vol 12, Iss 10, p 849 (2021)
The doublesex (dsx) gene, which encodes a transcription factor, regulates sexual differentiation in insects. Sex-specific splicing of dsx occurs to yield male- and female-specific isoforms, which promote male and female development, respectively. Thu
Externí odkaz:
https://doaj.org/article/8fae747fd58a408faad64e9786f34c37
Autor:
Hiroki Sakai, Megumi Sumitani, Yasuhiko Chikami, Kensuke Yahata, Keiro Uchino, Takashi Kiuchi, Susumu Katsuma, Fugaku Aoki, Hideki Sezutsu, Masataka G Suzuki
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006203 (2016)
In Bombyx mori (B. mori), Fem piRNA originates from the W chromosome and is responsible for femaleness. The Fem piRNA-PIWI complex targets and cleaves mRNAs transcribed from the Masc gene. Masc encodes a novel CCCH type zinc-finger protein and is req
Externí odkaz:
https://doaj.org/article/589b0045531d49d89af21d1596aecce5
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e82087 (2014)
In mice, transcription from the zygotic genome starts at the mid-one-cell stage after fertilization. Previous studies showed that an enhancer is not required for transcription at this stage, and that the enhancer-dependent mechanism of transcription
Externí odkaz:
https://doaj.org/article/b1d766113ea848868398a97ad92df4ad
Autor:
Masashi Yukawa, Tomohiko Akiyama, Vedran Franke, Nathan Mise, Takayuki Isagawa, Yutaka Suzuki, Masataka G Suzuki, Kristian Vlahovicek, Kuniya Abe, Hiroyuki Aburatani, Fugaku Aoki
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92689 (2014)
Genome-wide distribution of the majority of H2A and H3 variants (H2A, H2AX, H2AZ, macroH2A, H3.1, H3.2 and H3.3) was simultaneously investigated in mouse embryonic stem cells by chromatin immunoprecipitation sequencing. Around the transcription start
Externí odkaz:
https://doaj.org/article/cef9bbcde2ac43aa867060a32e9d6e50
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002279 (2011)
Upon fertilization, reprogramming of gene expression is required for embryo development. This step is marked by DNA demethylation and changes in histone variant composition. However, little is known about the molecular mechanisms causing these change
Externí odkaz:
https://doaj.org/article/bd1353673040486ea0fd28230d53af21
Publikováno v:
DNA repair. 117
Mammalian zygotes are hypersensitive to radiation exposure compared with later-stage embryos and somatic cells, which may be due to an unusual DNA damage response (DDR). DNA damage checkpoints are an essential part of the DDR, allowing for faithful r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e1d58a721f129f6eded9f9be0b64c6
https://pubmed.ncbi.nlm.nih.gov/35863142
https://pubmed.ncbi.nlm.nih.gov/35863142