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Noncovalent Engineering of Apoferritin with a PEGylated [FeFe] Hydrogenase Mimic for In Situ Polymerization

Autor: Xiaoxuan Wei, Luyang Ji, Jinlei Peng, Ke Du, Fude Feng

Publikováno v: ACS Applied Bio Materials. 5:1756-1765

Apoferritin can act as a scaffold for functionalization in the inner and outer surfaces. However, traditional covalent modification methods have a risk of disrupting the structure and physicochemical properties of apoferritin. Herein, we report a met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef52d294b74a9439481265f4e029fe7
https://doi.org/10.1021/acsabm.2c00124

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Photocatalytic Generation of Hydrogen Radical (H•) with GSH for Photodynamic Therapy

Autor: Jinlei Peng, Ke Du, Jian Sun, Xianli Yang, Xia Wang, Xiaoran Zhang, Gang Song, Fude Feng

Publikováno v: Angewandte Chemie (International ed. in English).

As a reactive hydrogen species, hydrogen radical (H•) scarcely sees applications in tumor biological therapy due to very limited resources of bio-friendly H• generator. In this work, we report that TAF can act as an organic photosensitizer as wel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8a53f0e77abb63160387d3cd5d79b9
https://pubmed.ncbi.nlm.nih.gov/36537886

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Visible Light and Glutathione Dually Responsive Delivery of a Polymer-Conjugated Temozolomide Intermediate for Glioblastoma Chemotherapy

Autor: Ke Du, Qiuyu Xia, Jian Sun, Fude Feng

Publikováno v: ACS Applied Materials & Interfaces. 13:55851-55861

Temozolomide (TMZ) is a prodrug of 5-(3-methyltriazene-1-yl)imidazole-4-carboxamide (MTIC, short-lived) and used as a first-line therapy drug for glioblastoma multiforme (GBM). However, little progress has been made in regulating the kinetics of TMZ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0a8d4cc7b09335803db37bd4ccdc23
https://doi.org/10.1021/acsami.1c16962

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Dithiol‐Activated Bioorthogonal Chemistry for Endoplasmic Reticulum‐Targeted Synergistic Chemophototherapy

Autor: Jian Sun, Xiaoran Zhang, Xia Wang, Jinlei Peng, Gang Song, Yufei Di, Fude Feng, Shu Wang

Publikováno v: Angewandte Chemie. 134

The controlled intracellular release of nitrite is still an unmet challenge due to the lack of bio-friendly donors, and the antitumor effect of nitrite is limited by its physiologically inert activity. Herein, we designed benzothiadiazole-based organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2103c983c8882661771876f2084750f3
https://doi.org/10.1002/ange.202213765

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Photoactivated In Situ Generation of Near Infrared Cyanines for Spatiotemporally Controlled Fluorescence Imaging in Living Cells

Autor: Gang Song, Hao Heng, Jiaqi Wang, Ronghua Liu, Yiming Huang, Huan Lu, Ke Du, Fude Feng, Shu Wang

Publikováno v: Angewandte Chemie International Edition. 60:16889-16893

Photoactivated trimerization of 2,3,3-trimethyl-3 H -indole derivatives created near infrared fluorophore Cy5. The synthetic method is air-tolerant, photosensitizer free, metal free, and condensation agent free. Living cells make Cy5 on a time scale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e2720156867ff7f3bb4430c38e5ed4
https://doi.org/10.1002/anie.202103706

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Intrinsic Mitochondrial Reactive Oxygen Species (ROS) Activate the In Situ Synthesis of Trimethine Cyanines in Cancer Cells

Autor: Hao Heng, Gang Song, Xuetong Cai, Jian Sun, Ke Du, Xiaoran Zhang, Xia Wang, Fude Feng, Shu Wang

Publikováno v: Angewandte Chemie (International ed. in English). 61(38)

Environment-responsive in situ synthesis of molecular fluorescent dyes is challenging. Herein, we develop a photoextension strategy to make trimethine cyanines with decent conversion efficiency (up to 81 %) using 1-butyl 2,3,3-trimethyl 3H-indole der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667353eca2b7f051b81eecdc7c91f6e9
https://pubmed.ncbi.nlm.nih.gov/35763340

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Temozolomide–Doxorubicin Conjugate as a Double Intercalating Agent and Delivery by Apoferritin for Glioblastoma Chemotherapy

Autor: Hao Heng, Fude Feng, Ke Du, Qiuyu Xia

Publikováno v: ACS Applied Materials & Interfaces. 12:34599-34609

We designed a conjugated compound by coupling temozolomide (TMZ) with doxorubicin (DOX) via an acylhydrazone linkage as a potential prodrug used for glioblastoma multiforme (GBM) treatment. Viscosity and spectroscopic studies revealed that the drug c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232874ef1993bd277cbc882e61b13b83
https://doi.org/10.1021/acsami.0c08531

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GSH and H 2 O 2 Co‐Activatable Mitochondria‐Targeted Photodynamic Therapy under Normoxia and Hypoxia

Autor: Jiajie Diao, Fude Feng, Shu Wang, Jian Sun, Xuetong Cai, Ke Du

Publikováno v: Angewandte Chemie International Edition. 59:12122-12128

Currently, photosensitizers (PSs) that are microenvironment responsive and hypoxia active are scarcely available and urgently desired for antitumor photodynamic therapy (PDT). Presented herein is the design of a redox stimuli activatable metal-free p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936ef4727d9f3889248c4dff6f5051c6
https://doi.org/10.1002/anie.202003895

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