Eight induced pluripotent stem cell lines (iPSCs) derived from two patients with Leukocyte adhesion deficiency Type I (LAD I) with mutations in the ITGB2 gene.

Autor: Fekadu-Siebald J; Goethe University, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt/Main, Germany., Fuchs NV; Section Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Zahn S; Research at the Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany., Rommel MGE; Institute for the Biology of Stem Cells, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Schenk F; Research at the Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany., Huenecke S; Goethe University, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt/Main, Germany., Bremm M; Goethe University, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt/Main, Germany., Kreyenberg H; Goethe University, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt/Main, Germany., Kuci Z; Goethe University, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt/Main, Germany., Jacobsen EM; Department of Pediatrics, University Medical Center Ulm, Ulm, Germany., Hoenig M; Department of Pediatrics, University Medical Center Ulm, Ulm, Germany., Schwarz K; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany; Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Württemberg - Hessen, Ulm, Germany., Bader P; Goethe University, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt/Main, Germany., Modlich U; Department of Gene and Cell Therapy, Institute for Regenerative Medicine - IREM, University of Zurich, Schlieren, Switzerland., König R; Section Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Bakhtiar S; Goethe University, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt/Main, Germany.

Publikováno v: Stem cell research [Stem Cell Res] 2024 Oct 24; Vol. 81, pp. 103598. Date of Electronic Publication: 2024 Oct 24.

Regulation of STING activity in DNA sensing by ISG15 modification.

Autor: Lin C; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Kuffour EO; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Fuchs NV; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Gertzen CGW; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Center for Structural Studies (CSS), Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Kaiser J; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Hirschenberger M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Tang X; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Xu HC; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Michel O; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Tao R; Institute for Virology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Haase A; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, 30625 Hannover, Germany; REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Martin U; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, 30625 Hannover, Germany; REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany., Kurz T; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Drexler I; Institute for Virology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Görg B; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Lang PA; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Luedde T; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany., König R; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Münk C; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address: carsten.muenk@med.uni-duesseldorf.de.

Publikováno v: Cell reports [Cell Rep] 2023 Nov 28; Vol. 42 (11), pp. 113277. Date of Electronic Publication: 2023 Oct 20.

Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA.

Autor: Yoh SM; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA. Electronic address: syoh@scripps.edu., Mamede JI; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612, USA., Lau D; EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia., Ahn N; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA., Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Temple J; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA., Tuckwell A; EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia., Fuchs NV; Host-Pathogen Interaction, Paul-Ehrlich-Institut, 63225 Langen, Germany., Cianci GC; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Riva L; Calibr, a Division of The Scripps Research Institute, La Jolla, CA 92037, USA., Curry H; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA., Yin X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R. China., Gambut S; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612, USA., Simons LM; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Hultquist JF; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., König R; Host-Pathogen Interaction, Paul-Ehrlich-Institut, 63225 Langen, Germany., Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Böcking T; EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia., Hope TJ; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Chanda SK; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA. Electronic address: schanda@scripps.edu.

Publikováno v: Molecular cell [Mol Cell] 2022 Aug 04; Vol. 82 (15), pp. 2871-2884.e6. Date of Electronic Publication: 2022 Jul 08.

Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1).

Autor: Fuchs NV; Host-Pathogen Interactions, Paul-Ehrlich-Institut, 63225 Langen, Germany., Schieck M; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Neuenkirch M; Host-Pathogen Interactions, Paul-Ehrlich-Institut, 63225 Langen, Germany., Tondera C; Host-Pathogen Interactions, Paul-Ehrlich-Institut, 63225 Langen, Germany., Schmitz H; Host-Pathogen Interactions, Paul-Ehrlich-Institut, 63225 Langen, Germany., Wendeburg L; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Steinemann D; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Elpers C; Department of General Pediatrics, Muenster University Children's Hospital, Münster, Germany., Rutsch F; Department of General Pediatrics, Muenster University Children's Hospital, Münster, Germany., König R; Host-Pathogen Interactions, Paul-Ehrlich-Institut, 63225 Langen, Germany; Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, United States. Electronic address: renate.koenig@pei.de.

Publikováno v: Stem cell research [Stem Cell Res] 2020 Mar; Vol. 43, pp. 101697. Date of Electronic Publication: 2020 Jan 09.

Induced pluripotent stem cells (iPSCs) derived from a renpenning syndrome patient with c.459_462delAGAG mutation in PQBP1 (PEIi001-A).

Autor: Fuchs NV; Host‑Pathogen Interactions, Paul-Ehrlich-Institut, Langen 63225, Germany., Schieck M; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Neuenkirch M; Host‑Pathogen Interactions, Paul-Ehrlich-Institut, Langen 63225, Germany., Tondera C; Host‑Pathogen Interactions, Paul-Ehrlich-Institut, Langen 63225, Germany., Schmitz H; Host‑Pathogen Interactions, Paul-Ehrlich-Institut, Langen 63225, Germany., des Portes V; National Reference Center for Fragile X and Other XLID, Biobank NeuroBioTec, Bron, France; Hospices Civils de Lyon, Université de Lyon and CNRS UMR 5304 (L2C2), Bron, France., Germanaud D; Université de Paris, UMR1141 NeuroDiderot, InDev team, Inserm, CEA, Paris, France; AP-HP, Hôpital Robert Debré, Service de Neurologie Pédiatrique et des Maladies Métaboliques, Paris, France., Steinemann D; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Göhring G; Department of Human Genetics, Hannover Medical School, Hannover, Germany., König R; Host‑Pathogen Interactions, Paul-Ehrlich-Institut, Langen 63225, Germany; Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: renate.koenig@pei.de.

Publikováno v: Stem cell research [Stem Cell Res] 2019 Dec; Vol. 41, pp. 101592. Date of Electronic Publication: 2019 Oct 15.