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$\mathsf{G^2Retro}$ as a Two-Step Graph Generative Models for Retrosynthesis Prediction

Autor: Chen, Ziqi, Ayinde, Oluwatosin R., Fuchs, James R., Sun, Huan, Ning, Xia

Publikováno v: Commun Chem 6, 102 (2023)

Retrosynthesis is a procedure where a target molecule is transformed into potential reactants and thus the synthesis routes can be identified. Recently, computational approaches have been developed to accelerate the design of synthesis routes. In thi

Externí odkaz: http://arxiv.org/abs/2206.04882

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The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

Autor: Li Pui-Kai, Schwartz Eric B, Li Chenglong, Lin Jiayuh, Bear Misty D, Fossey Stacey L, Fuchs James R, Fenger Joelle, Kisseberth William C, London Cheryl A

Publikováno v: BMC Cancer, Vol 11, Iss 1, p 112 (2011)

Abstract Background Curcumin is a naturally occurring phenolic compound shown to have a wide variety of antitumor activities; however, it does not attain sufficient blood levels to do so when ingested. Using structure-based design, a novel compound,

Externí odkaz: https://doaj.org/article/91e36158d2fc401db3a0ed3b64c00abf

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A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

Autor: Lin Li, Deangelis Stephanie, Foust Elizabeth, Fuchs James, Li Chenglong, Li Pui-Kai, Schwartz Eric B, Lesinski Gregory B, Benson Don, Lü Jiagao, Hoyt Dale, Lin Jiayuh

Publikováno v: Molecular Cancer, Vol 9, Iss 1, p 217 (2010)

Abstract Background Targeting Signal Transducer and Activator of Transcription 3 (STAT3) signaling is an attractive therapeutic approach for most types of human cancers with constitutively activated STAT3. A novel small molecular STAT3 inhibitor, FLL

Externí odkaz: https://doaj.org/article/2b64209366c74e338d91f1619bbb867a

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The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

Autor: Young Gregory S, Fossey Stacey L, Hoyt Dale G, Lin Jiayuh, Abdelhamid Dalia, Schwartz Eric B, Benson Don M, Bakan Courtney, Yui Jennifer, Li Chenglong, Fuchs James R, Bill Matthew A, Carson William E, Li Pui-Kai, Lesinski Gregory B

Publikováno v: Molecular Cancer, Vol 9, Iss 1, p 165 (2010)

Abstract Background We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway t

Externí odkaz: https://doaj.org/article/f3aff333fbda4d3d8d697c842c935fd4

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New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells

Autor: Fuchs James R, Chen Chun-Liang, DeAngelis Stephanie, Ball Sarah, Hutzen Brian, Cen Ling, Li Chenglong, Li Pui-Kai, Lin Jiayuh

Publikováno v: BMC Cancer, Vol 9, Iss 1, p 99 (2009)

Abstract Background Colorectal carcinoma is one of the major causes of morbidity and mortality in the Western World. Novel therapeutic approaches are needed for colorectal carcinoma. Curcumin, the active component and yellow pigment of turmeric, has

Externí odkaz: https://doaj.org/article/80b7ffcae11c49798c26b6b39b7e213d

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