Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Fucheng Qu"'
Autor:
Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1196-1205
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was sh
Autor:
Gary J. Grover, Narayanan Hariharan, Wei Wang, Dennis Farrelly, Jeon Yoon T, Fucheng Qu, Rajasree Golla, Zhengping Ma, Lisa Moore, Arthur M. Doweyko, Gamini Chandrasena, Pratik Devasthale, Denis E. Ryono, Lin Cheng, Chen Sean, Peter T. W. Cheng, Wei Sun, Ramakrishna Seethala, Paul G. Sleph, Hao Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2312-2316
A novel series of potent dual agonists of PPARα and PPARγ, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists
Autor:
Narayanan Hariharan, Kasim A. Mookhtiar, Liqun Gu, Jimmy Ren, Chen Sean, Ramakrishna Seethala, Michael Cap, Lori Kunselman, Min Zhou, Peter T. W. Cheng, William Fenderson, Chunning Shao, Cuixia Chu, Scott A. Biller, Hao Zhang, Fucheng Qu, Pratik Devasthale, Dennis Farrelly, Jeon Yoon T, Randolph P. Ponticiello, John R. Wetterau, Wei Wang, Wen-Pin Yang, Thomas Harrity, Aaron Tieman, Denis E. Ryono, Richard E. Gregg
Publikováno v:
Diabetes. 55:240-248
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor (PPAR) activator, was investigated for its antidiabetic properties and its effects on metabolic abnormalities in genetically obese diabetic db/db mice. In db/db mice
Publikováno v:
Tetrahedron. 55:9073-9088
In view of biological activities of both 1,3-dioxolanyl nucleosides and C-nucleosides, d - and l -1,3-dioxolanyl C-nucleosides have been synthesized as potential antiviral and/or anticancer agents. Asymmetric synthesis of four new optically pure d -
Structure−Activity Relationships of l -Dioxolane Uracil Nucleosides as Anti-Epstein Barr Virus Agents
Autor:
Chung K. Chu, Elizabeth A. Gullen, Ju-Sheng Lin, Yung-Chi Cheng, Toshihiko Kira, Fucheng Qu, Yongseok Choi
Publikováno v:
Journal of Medicinal Chemistry. 42:2212-2217
A series of 1,3-dioxolanyluracil analogues was prepared from the dioxolane intermediates 2, and their anti-Epstein Barr virus (anti-EBV) activities were detemined. The potency of l-dioxolane uracil nucleosides against EBV replication is dependent on
Autor:
Denis E. Ryono, Chen Sean, Pratik Devasthale, Shu Y Chang, John R. Wetterau, W. Griffith Humphreys, Gary J. Grover, Dennis Farrelly, Jeon Yoon T, Fucheng Qu, Ramakrishna Seethala, Narayanan Hariharan, Wei Wang, Zhengping Ma, Scott A. Biller, Rajasree Golla, Lisa Moore, Arthur M. Doweyko, Michael Cap, Fred Selan, Jimmy Ren, Paul G. Sleph, Hao Zhang, Aaron Tieman, Vito G. Sasseville, Thomas Harrity, Gamini Chandrasena, Chunning Shao, Peter T. W. Cheng, Lin Cheng, Wei Sun
Publikováno v:
Journal of Medicinal Chemistry. 48:2248-2250
Muraglitazar/BMS-298585 (2) has been identified as a non-thiazolidinedione PPAR alpha/gamma dual agonist that shows potent activity in vitro at human PPARalpha (EC(50) = 320 nM) and PPARgamma(EC(50) = 110 nM). Compound 2 shows excellent efficacy for
Publikováno v:
Tetrahedron Letters. 36:8167-8170
Asymmetric synthesis of four novel C-nucleosides, (2′R,5′R)-, (2′S,5′R)-, (2′S,5′S)- and (2′R,5′S)-2-[2-hydroxymelhy])-1,3-dioxolan-5-yl]-1 ,3-thiazole-4-carboxamide has been accomplished by the condensation of key intermediates, 2-(1
Autor:
Haixia Wang, Stephen G. Swartz, Brian J. Murphy, James J. Li, Paul G. Sleph, Fucheng Qu, Neil Flynn, Scott A. Biller, Dorothy Slusarchyk, Ramakrishna Seethala, Gary J. Grover, Andres S. Hernandez, David A. Gordon, Jun Li, Mujing Yan, Jeffrey A. Robl, Joseph A. Tino
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(8)
A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetiz
Autor:
Mujing Yan, Jeffrey A. Robl, Hongjian Zhang, Haixia Wang, Ramakrishna Seethala, Christa M. Musial, Bharat P. Patel, David A. Gordon, Terry R. Stouch, James J. Li, Kenneth E.J. Dickinson, Peter T. W. Cheng, Blake C. Beehler, Brian J. Murphy, Jun Li, Leah Giupponi, Shiwei Tao, Fucheng Qu, Gary J. Grover, Joseph A. Tino, Sam T. Chao, Mark A. Smith, William G. Humphreys, Neil Flynn, Dorothy Slusarchyk, William R. Ewing, Stephanie Y. Chen, Andres S. Hernandez, Stephen G. Swartz, Mark D. Schwinden, Paul G. Sleph, Scott A. Biller
Publikováno v:
Journal of medicinal chemistry. 50(24)
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced
Autor:
Pratik V, Devasthale, Sean, Chen, Yoon, Jeon, Fucheng, Qu, Denis E, Ryono, Wei, Wang, Hao, Zhang, Lin, Cheng, Dennis, Farrelly, Rajasree, Golla, Gary, Grover, Zhengping, Ma, Lisa, Moore, Ramakrishna, Seethala, Wei, Sun, Arthur M, Doweyko, Gamini, Chandrasena, Paul, Sleph, Narayanan, Hariharan, Peter T W, Cheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(8)
A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamm