Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Fucheng, Qu"'
Autor:
Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1196-1205
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9c9221e9206ed0e57f44f10281d7ab
https://doi.org/10.1016/j.bmcl.2015.01.066
https://doi.org/10.1016/j.bmcl.2015.01.066
Autor:
Gary J. Grover, Narayanan Hariharan, Wei Wang, Dennis Farrelly, Jeon Yoon T, Fucheng Qu, Rajasree Golla, Zhengping Ma, Lisa Moore, Arthur M. Doweyko, Gamini Chandrasena, Pratik Devasthale, Denis E. Ryono, Lin Cheng, Chen Sean, Peter T. W. Cheng, Wei Sun, Ramakrishna Seethala, Paul G. Sleph, Hao Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2312-2316
A novel series of potent dual agonists of PPARα and PPARγ, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd833e6d647f89a09342d5bb9c6b46a1
https://doi.org/10.1016/j.bmcl.2007.01.060
https://doi.org/10.1016/j.bmcl.2007.01.060
Autor:
Narayanan Hariharan, Kasim A. Mookhtiar, Liqun Gu, Jimmy Ren, Chen Sean, Ramakrishna Seethala, Michael Cap, Lori Kunselman, Min Zhou, Peter T. W. Cheng, William Fenderson, Chunning Shao, Cuixia Chu, Scott A. Biller, Hao Zhang, Fucheng Qu, Pratik Devasthale, Dennis Farrelly, Jeon Yoon T, Randolph P. Ponticiello, John R. Wetterau, Wei Wang, Wen-Pin Yang, Thomas Harrity, Aaron Tieman, Denis E. Ryono, Richard E. Gregg
Publikováno v:
Diabetes. 55:240-248
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor (PPAR) activator, was investigated for its antidiabetic properties and its effects on metabolic abnormalities in genetically obese diabetic db/db mice. In db/db mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d94ba455d51e1e5f39b4a1484a6b08
https://doi.org/10.2337/diabetes.55.01.06.db05-0648
https://doi.org/10.2337/diabetes.55.01.06.db05-0648
Structure−Activity Relationships of l -Dioxolane Uracil Nucleosides as Anti-Epstein Barr Virus Agents
Autor:
Chung K. Chu, Elizabeth A. Gullen, Ju-Sheng Lin, Yung-Chi Cheng, Toshihiko Kira, Fucheng Qu, Yongseok Choi
Publikováno v:
Journal of Medicinal Chemistry. 42:2212-2217
A series of 1,3-dioxolanyluracil analogues was prepared from the dioxolane intermediates 2, and their anti-Epstein Barr virus (anti-EBV) activities were detemined. The potency of l-dioxolane uracil nucleosides against EBV replication is dependent on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac729a067a81f24b2298fbfdf46c2050
https://doi.org/10.1021/jm9806749
https://doi.org/10.1021/jm9806749
Publikováno v:
Tetrahedron Letters. 36:8167-8170
Asymmetric synthesis of four novel C-nucleosides, (2′R,5′R)-, (2′S,5′R)-, (2′S,5′S)- and (2′R,5′S)-2-[2-hydroxymelhy])-1,3-dioxolan-5-yl]-1 ,3-thiazole-4-carboxamide has been accomplished by the condensation of key intermediates, 2-(1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5d8ad388c3f6995732eeb81cb9ea500
https://doi.org/10.1016/0040-4039(95)01763-8
https://doi.org/10.1016/0040-4039(95)01763-8
Autor:
Haixia Wang, Stephen G. Swartz, Brian J. Murphy, James J. Li, Paul G. Sleph, Fucheng Qu, Neil Flynn, Scott A. Biller, Dorothy Slusarchyk, Ramakrishna Seethala, Gary J. Grover, Andres S. Hernandez, David A. Gordon, Jun Li, Mujing Yan, Jeffrey A. Robl, Joseph A. Tino
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(8)
A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a043bdc78bf0bf106d77a02ad3c9713
https://pubmed.ncbi.nlm.nih.gov/18378446
https://pubmed.ncbi.nlm.nih.gov/18378446
Autor:
Pratik V, Devasthale, Sean, Chen, Yoon, Jeon, Fucheng, Qu, Denis E, Ryono, Wei, Wang, Hao, Zhang, Lin, Cheng, Dennis, Farrelly, Rajasree, Golla, Gary, Grover, Zhengping, Ma, Lisa, Moore, Ramakrishna, Seethala, Wei, Sun, Arthur M, Doweyko, Gamini, Chandrasena, Paul, Sleph, Narayanan, Hariharan, Peter T W, Cheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(8)
A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba9ce72890feecec8742fc4d1948e12b
https://pubmed.ncbi.nlm.nih.gov/17292606
https://pubmed.ncbi.nlm.nih.gov/17292606
Autor:
Brian J. Murphy, Melissa Kung, Fucheng Qu, James J. Li, Gary J. Grover, Kenneth E.J. Dickinson, Neil Flynn, Dorothy Slusarchyk, Haixia Wang, David A. Gordon, Joseph A. Tino, Paul G. Sleph, Robert H. Stoffel, Ramakrishna Seethala, Leah Giupponi, Jeffrey A. Robl, Christa M. Musial, Rajasree Golla
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(7)
Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc8fb30e76b5e5e8891c88dae7768cf
https://pubmed.ncbi.nlm.nih.gov/15780609
https://pubmed.ncbi.nlm.nih.gov/15780609
Autor:
Ju-Sheng Lin, Toshihiko Kira, Yung-Chi Cheng, Yongseok Choi, Ginger E. Dutschman, Susan P. Grill, Fucheng Qu, Chung K. Chu
β- l -5-Iododioxolane uracil was shown to have potent anti-Epstein-Barr virus (EBV) activity (50% effective concentration = 0.03 μM) with low cytotoxicity (50% cytotoxic concentration = 1,000 μM). It exerts its antiviral activity by suppressing re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e21bb4c15dda9787531bca62172991
https://europepmc.org/articles/PMC90192/
https://europepmc.org/articles/PMC90192/
Autor:
Jun Li, Stephanie Y. Chen, James J. Li, Haixia Wang, Andres S. Hernandez, Shiwei Tao, Christa M. Musial, Fucheng Qu, Stephen Swartz, Sam T. Chao, Neil Flynn, Brian J. Murphy, Dorothy A. Slusarchyk, Ramakrishna Seethala, Mujing Yan, Paul Sleph, Gary Grover, Mark A. Smith, Blake Beehler, Leah Giupponi
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 24, p5890-5893, 4p