Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fubao Huang"'
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::315c96d218187ab93d544ea133fd6fce
https://doi.org/10.1002/cbic.202300376
https://doi.org/10.1002/cbic.202300376
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325d95ed377de7ed93e721def7bc25bb
https://doi.org/10.1002/cbic.202300168
https://doi.org/10.1002/cbic.202300168
Publikováno v:
Medicinal Research Reviews
Inflammation is thought to play an important role in the pathogenesis of vascular diseases. Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) mediates vascular inflammation through the regulation of lipid metabolism in blood, thus, it has been ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ca0af32f51126501d047a38d746294
https://doi.org/10.1002/med.21597
https://doi.org/10.1002/med.21597
Autor:
Minjun Li, Ruimin Huang, Yishen Liu, Wenwei Xu, Jianhua Shen, Kai Wang, Chengyuan Peng, Yu Zhang, Jing Gao, Hangchen Hu, Hu Zhou, Yechun Xu, Fubao Huang
Publikováno v:
Journal of medicinal chemistry. 63(13)
Covalent ligands are of great interest as therapeutic drugs or biochemical tools. Here, we reported the discovery of highly selective and irreversible inhibitors of lipoprotein-associated phospholipase A2 (Lp-PLA2) using a covalent fragment-based app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f571c6fada7ba9099dae5a0cbaa96f8f
https://pubmed.ncbi.nlm.nih.gov/32459096
https://pubmed.ncbi.nlm.nih.gov/32459096
Autor:
Kai Wang, Xiaomei Li, Lu Chang, Hui Xu, Jianhua Shen, Fubao Huang, Xiao‐li Zheng, Feifei Lin, Jia Liu, Shilin Li, Haonan Duan, Fanghui Han
Publikováno v:
Analytical and bioanalytical chemistry. 412(13)
In the intestine, several phenols and aromatic acids are generated by microbiota and are highly related to the formation of uremic toxins. Herein, we developed a new derivatization reagent, 2-bromo-1-[4-(dimethylamino)phenyl] ethyl ketone (BDAPE), th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c33cf5065d90c504145351c5bd666ac
https://pubmed.ncbi.nlm.nih.gov/32342129
https://pubmed.ncbi.nlm.nih.gov/32342129
Publikováno v:
Journal of medicinal chemistry. 62(23)
Although intensively expressed within intestine, the precise roles of intestinal dipeptidyl peptidase IV (DPPIV) in numerous pathologies remain incompletely understood. Here, we first reported a nonsystemic intestine-targeted (NSIT) DPPIV inhibitor w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db0d8e0a76ac101dde4e663b02d791f
https://pubmed.ncbi.nlm.nih.gov/31747282
https://pubmed.ncbi.nlm.nih.gov/31747282
Publikováno v:
Journal of medicinal chemistry. 60(24)
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a promising therapeutic target for atherosclerosis, Alzheimer's disease, and diabetic macular edema. Here we report the identification of novel sulfonamide scaffold Lp-PLA2 inhibitors derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94222fa7c8049c208973c51dc2eb4ebb
https://pubmed.ncbi.nlm.nih.gov/29193967
https://pubmed.ncbi.nlm.nih.gov/29193967
Publikováno v:
Journal of Medicinal Chemistry; 12/28/2017, Vol. 60 Issue 24, p10231-10244, 14p