Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Fuao Cao"'
Autor:
Hao Fan, Xuefei Hu, Fuao Cao, Leqi Zhou, Rongbo Wen, Hao Shen, Yating Fu, Xiaoming Zhu, Hang Jia, Zixuan Liu, Guimin Wang, Guanyu Yu, Wenjun Chang, Wei Zhang
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract Protein tyrosine phosphatase SHP2 activates RAS signaling, which is a novel target for colorectal cancer (CRC) therapy. However, SHP2 inhibitor monotherapy is ineffective for metastatic CRC and a combination therapy is required. In this stud
Externí odkaz:
https://doaj.org/article/5452f55c0d5640f2a58081fe82de3dbe
Autor:
Hao Shen, Jie Yuan, Dafeng Tong, Bingchen Chen, Enda Yu, Guanglei Chen, Cheng Peng, Wenjun Chang, Jifu E, Fuao Cao
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-13 (2024)
Abstract Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking effective biomarkers and therapeutic targets. Revealing the critical pathogenic factors of CRC and the underlying mechanisms would offer potential ther
Externí odkaz:
https://doaj.org/article/6891a688014545cfa0888d04bd95ae5f
Autor:
Jie Yuan, Fan Jiang, Xiaochao Fu, Yun Hou, Yali Hu, Qishun Yang, Liyang Liu, Yufu Wang, Wangwang Sheng, Fuao Cao, Jinghu He, Guanglei Chen, Cheng Peng, Wei Jiang
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundEnterostomy is important for radical resection of colorectal cancer (CRC). Nevertheless, the notable occurrence of complications linked to enterostomy results in a reduction in patients’ quality of life and impedes adjuvant therapy. This
Externí odkaz:
https://doaj.org/article/60fe2a7375944089aa893a55f5cd2139
Autor:
Rongbo Wen, Leqi Zhou, Zhiying Peng, Hao Fan, Tianshuai Zhang, Hang Jia, Xianhua Gao, Liqiang Hao, Zheng Lou, Fuao Cao, Guanyu Yu, Wei Zhang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Colorectal Cancer (CRC) is one of the most common gastrointestinal tumors, and its high tumor heterogeneity makes traditional sequencing methods incapable of obtaining information about the heterogeneity of individual cancer cells in CRC. Therefore,
Externí odkaz:
https://doaj.org/article/93eecc2f9458445b98bf392df90b9f43
Autor:
Nanxin Zheng, Rongbo Wen, Leqi Zhou, Qingying Meng, Kuo Zheng, Zhixuan Li, Fuao Cao, Wei Zhang
Publikováno v:
Translational Oncology, Vol 27, Iss , Pp 101570- (2023)
Background: : The tumor microenvironment (TME) plays a critical role in shaping tumor progression and determining the outcome of the therapeutic response. In this study, we aimed to generate a comprehensive cellular landscape of the colorectal cancer
Externí odkaz:
https://doaj.org/article/4aafdbabcc6945d9ad2d577da041f4c0
Autor:
Guanyu Yu, Mengnan Xu, Leqi Zhou, Kuo Zheng, Xiaoming Zhu, Jinke Sui, Cheng Xin, Wenjun Chang, Wei Zhang, Fuao Cao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Phosphorylated Focal adhesion kinase (FAK) has been reported to be intimately involved in various malignant tumors. The effect of p-FAK on colorectal cancer (CRC) is still disputable. The purpose of this study is to investigate the role o
Externí odkaz:
https://doaj.org/article/e16449fd2e1a4b698da75f3b02a4b966
Autor:
Mengmeng Song, Ye Li, Mingyong Miao, Fan Zhang, Hao Yuan, Fuao Cao, Wenjun Chang, Hanping Shi, Chunhua Song
Publikováno v:
Cancer Medicine, Vol 9, Iss 6, Pp 2030-2038 (2020)
Abstract Purpose Nicotinamide n‐methyltransferase (NNMT) has good biochemical activity and epigenetic regulation, and has been reported as a major metabolic regulator of cancer. The goal of this study was to investigate the significance of stromal
Externí odkaz:
https://doaj.org/article/dcd8ada73dd04f0e883974804c7972ce
Autor:
Ye Li, Yuncang Yuan, Fan Zhang, Aizhen Guo, Fuao Cao, Mengmeng Song, Yating Fu, Xiaowen Xu, Hao Shen, Shangyong Zheng, Yamin Pan, Wenjun Chang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
SHP2 mediates signaling from multiple receptor tyrosine kinases (RTKs) to extracellular signal-regulated kinase (ERK) and Ser and Thr kinase AKT, and its inhibitors offer an unprecedented opportunity for cancer treatment. Although the ERK signaling v
Externí odkaz:
https://doaj.org/article/5b77e158ef9f4631b187c840f6022ce3
Autor:
Peng Liu, Fuao Cao, Jinke Sui, Yonggang Hong, Qizhi Liu, XianHua Gao, Haifeng Gong, Liqiang Hao, Zheng Lou, Wei Zhang
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
BackgroundAltered expression profile of microRNAs (miRNAs) was reported to be associated with colorectal cancer (CRC). The aims of this study are to identify the changed miRNAs in the plasma of CRC patients and explore the underlying mechanism of the
Externí odkaz:
https://doaj.org/article/95597212a0cf4949b083264e3586ded1
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Extracellular and/or intracellular manipulation of pH in tumor may have noticeable potential in cancer treatment. Although the assembly factor genes of V0 domain of the V-ATPase complex are required for intracellular pH homeostasis, their significanc
Externí odkaz:
https://doaj.org/article/331832ebb9ab4916b78588af23993464