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Akademický článek

Tetrandrine Induces Apoptosis of Human Nasopharyngeal Carcinoma NPC-TW 076 Cells through Reactive Oxygen Species Accompanied by an Endoplasmic Reticulum Stress Signaling Pathway

Autor: Ya-Jing Lin, Shu-Fen Peng, Meng-Liang Lin, Chao-Lin Kuo, Kung-Wen Lu, Ching-Lung Liao, Yi-Shih Ma, Fu-Shin Chueh, Kuo-Ching Liu, Fu-Shun Yu, Jing-Gung Chung

Publikováno v: Molecules, Vol 21, Iss 10, p 1353 (2016)

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck and the incidence is higher in Southeast Asia. Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid, a natural product, and exhibits biological activities including acti

Externí odkaz: https://doaj.org/article/f3bf3711ea054d92ad45aab2dbc10c52

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Gypenosides induce cell death and alter gene expression in human oral cancer HSC-3 cells

Autor: Yi Ping Huang, Jing Gung Chung, Ching Lung Liao, Yung Lin Chu, Fu Shun Yu, Rick Sai-Chuen Wu, Yi Shih Ma, Kung Wen Lu, Fu Shin Chueh

Publikováno v: Experimental and Therapeutic Medicine

Gypenosides (Gyp), the primary components of Gynostemma pentaphyllum Makino, have long been used as a Chinese herbal medicine. In the present study, the effects of Gyp on cell viability, the cell cycle, cell apoptosis, DNA damage and chromatin conden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a438259dcc6f22e339c9294ab60d7d5f
https://doi.org/10.3892/etm.2017.4840

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Fisetin-induced apoptosis of human oral cancer SCC-4 cells through reactive oxygen species production, endoplasmic reticulum stress, caspase-, and mitochondria-dependent signaling pathways

Autor: Yi Shih Ma, Chen Hsuan Su, Jing Gung Chung, Yung Lin Chu, Jiun Long Yang, Kung Wen Lu, Chao Lin Kuo, Fu Shin Chueh, Fu Shun Yu, Kuo Ching Liu

Publikováno v: Environmental Toxicology. 32:1725-1741

Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98a3579bc82468c18fcd6d552743b4a
https://doi.org/10.1002/tox.22396

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Anticancer effects of cantharidin in A431 human skin cancer (Epidermoid carcinoma) cells in vitro and in vivo

Autor: Fu Shun Yu, Chi Chuan Li, Jin-Cherng Lien, Ming Jen Fan, Jing Gung Chung, Yu Cheng Chou, Shu Fen Peng, Ya Yin Chen, Hsu Feng Lu, Wen Wen Huang, Nou Ying Tang

Publikováno v: Environmental Toxicology. 32:723-738

Cantharidin (CTD), a potential anticancer agent of Traditional Chinese Medicine has cytotxic effects in different human cancer cell lines. The cytotoxic effects of CTD on A431 human skin cancer (epidermoid carcinoma) cells in vitro and in A431 cell x

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e65447cb69bafa1db933a2b50238ee83
https://doi.org/10.1002/tox.22273

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Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy

Autor: Kuang Chi Lai, Shu Jen Chang, Jin-Cherng Lien, An Cheng Huang, Fu Shun Yu, Meng Wei Lin, Jing Gung Chung

Publikováno v: Environmental Toxicology. 32:329-343

Tetrandrine, a bisbenzylisoquinoline alkaloid, is extracted from the root of the Chinese herb Radix Stephania tetrandra S Moore. This compound has antitumor activity in different cancer cell types. In this study, the effects of tetrandrine on human o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a8b5a488b84dd2c4a9804aff7643917
https://doi.org/10.1002/tox.22238

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Allyl Isothiocyanate Induces Cell Toxicity by Multiple Pathways in Human Breast Cancer Cells

Autor: Yu Cheng Chou, Chun Shu Yu, Fu Shun Yu, Jing Gung Chung, Peng Bo, Jin-Cherng Lien, Chien Chih Yu, Hsu Feng Lu, Ya Yin Chen

Publikováno v: The American Journal of Chinese Medicine. 44:415-437

Isothiocyanates (ITCs) occur in many cruciferous vegetables. These compounds, which have significant anticancer actions, can induce apoptosis in different human cancer cell lines. In the present study, we investigated if allyl isothiocyanate (AITC) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1854a66a41af1cde0b63a12ac94c7f2
https://doi.org/10.1142/s0192415x16500245

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Antitumor effects of deguelin on H460 human lung cancer cellsin vitroandin vivo: Roles of apoptotic cell death and H460 tumor xenografts model

Autor: Chun Shu Yu, Yu Chieh Hsu, Rick Sai-Chuen Wu, Fu Shun Yu, Jo Hua Chiang, Kuang Chi Lai, Te Chun Hsia, Jin-Cherng Lien, Jing Gung Chung

Publikováno v: Environmental Toxicology. 32:84-98

Deguelin, a naturally occurring rotenoid of the flavonoid family, is known to be an Akt inhibitor, to have chemopreventive activities and anti-tumor effect on several cancers. In this study, investigation to elucidate the effect of deguelin on apopto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3035ea1410127f5c5c66a442aa3a39d
https://doi.org/10.1002/tox.22214

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Suppression of the migration and invasion is mediated by triptolide in B16F10 mouse melanoma cells through the NF-kappaB-dependent pathway

Autor: Chun Shu Yu, Shu Jen Chang, Hui Yu Jao, Jing Gung Chung, Bin Chuan Ji, Fu Shun Yu, Kuo Ching Liu, Da Tian Bau, Ching Lung Liao

Publikováno v: Environmental Toxicology. 31:1974-1984

Melanoma cancer is one of the major causes of death in humans worldwide. Triptolide is one of the active components of Tripterygium wilfordii Hook F, and has biological activities including induced cell cycle arrest and induction of apoptosis but its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b44b0fe78f8d19421ef027fec95a3ea8
https://doi.org/10.1002/tox.22198

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PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, Rho A, and Ras with inhibition of MMP-2, -7 and -9 gene expression

Autor: Hsin Chung Liu, Mei Jen Wang, Chih Huang Hung, Meng Ya Chang, Tomor Harnod, Hsu Tung Lee, Yu Cheng Chou, Jing Gung Chung, Fu Shun Yu

Publikováno v: Oncology Reports. 34:2489-2496

Glioblastoma is the most aggressive primary brain malignancy, and the efficacy of multimodality treatments remains unsatisfactory. Phenethyl isothiocyanate (PEITC), one member of the isothiocyanate family, was found to inhibit the migration and invas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629b0828f209136639e11ac552e29dde
https://doi.org/10.3892/or.2015.4260

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Bufalin Inhibits NCI-H460 Human Lung Cancer Cell MetastasisIn Vitroby Inhibiting MAPKs, MMPs, and NF-κB Pathways

Autor: Shu Chun Hsu, Jaw-Chyun Chen, Hsin Chung Liu, Fu Shun Yu, Chao Lin Kuo, Yung Ting Hsiao, Te Chun Hsia, Ping Ping Wu, Shin Hwar Wu, Wu-Huei Hsu, Jing Gung Chung

Publikováno v: The American Journal of Chinese Medicine. 43:1247-1264

Bufalin, a component of Chan Su (a traditional Chinese medicine), has been known to have antitumor effects for thousands of years. In this study, we investigated its anti-metastasis effects on NCI-H460 lung cancer cells. Under sub-lethal concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3104eaf6c2400c6bcda0b108083752dd
https://doi.org/10.1142/s0192415x15500718

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