Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Fu-Ming Kuo"'
Autor:
Fu Ming Kuo, Chin Yu Lin, Chun Feng Chang, An Siou Li, Hsing Pang Hsieh, Teng Kuang Yeh, Jen Shin Song, Shu Yu Lin, Chun Hwa Chen, Mohane Selvaraj Coumar, Po Chu Kuo, Sing Yi Wang, Mu Chun Li, Wen-Hsing Lin, Chen Ming Yang, Pei Yi Chen, John T.A. Hsu
Publikováno v:
Bioorganic chemistry. 98
In an effort to develop new cancer therapeutics, we have reported clinical candidate BPR1K871 (1) as a potentanticancercompound in MOLM-13 and MV4-11 leukemia models, as well as in colorectal and pancreatic animal models. As BPR1K871 lacks oral bioav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5477e2465975a7f72145a43d0b9932
https://pubmed.ncbi.nlm.nih.gov/32171993
https://pubmed.ncbi.nlm.nih.gov/32171993
Autor:
Sing Yi Wang, Pei Yi Chen, Yung Chang Hsu, Teng Kuang Yeh, Hsu Yi Sun, Chun Hwa Chen, Kai-Chia Yeh, Shu Yu Lin, Su Ying Wu, Hsing Pang Hsieh, Ching Ping Chen, Chiung-Tong Chen, Hui Yi Shiao, Yi Hui Peng, Tzu Wen Lien, Fu Ming Kuo, Yi Yu Ke, Wen-Hsing Lin, Chang Ying Chu, Tsu An Hsu
Publikováno v:
Journal of medicinal chemistry. 62(22)
Epidermal growth factor receptor (EGFR)-targeted therapy in non-small cell lung cancer represents a breakthrough in the field of precision medicine. Previously, we have identified a lead compound, furanopyrimidine 2, which contains a (S)-2-phenylglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0a7f2358d5cec8f896161d0fefb55
https://pubmed.ncbi.nlm.nih.gov/31560541
https://pubmed.ncbi.nlm.nih.gov/31560541
Autor:
Wen Chieh Wang, Yun I. Chang, Fu Ming Kuo, Po Chu Kuo, Ching Ping Chen, Chiung-Tong Chen, Jen Shin Song, Mohane Selvaraj Coumar, Ching Chuan Kuo, Chun Wei Chang, An Siou Li, Ming Hsine Wu, Yi Yu Ke, Teng Kuang Yeh, Sing Yi Wang, Hui Yi Shiao, Kuei Jung Yen, Yung Chang Hsu, Chun Hwa Chen, Wen-Hsing Lin, Hsing Pang Hsieh, John T.A. Hsu, Pei Yi Chen, Chen Lung Huang, Chuan Shih
Publikováno v:
Oncotarget
// Yung Chang Hsu 1, * , Mohane Selvaraj Coumar 2, * , Wen-Chieh Wang 1, * , Hui-Yi Shiao 1, * , Yi-Yu Ke 1 , Wen-Hsing Lin 1 , Ching-Chuan Kuo 1 , Chun-Wei Chang 1 , Fu-Ming Kuo 1 , Pei-Yi Chen 1 , Sing-Yi Wang 1 , An-Siou Li 1 , Chun-Hwa Chen 1 , P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a2eb341741edb83e6b9a1de9e85c4
https://doi.org/10.18632/oncotarget.13369
https://doi.org/10.18632/oncotarget.13369
Publikováno v:
Tetrahedron. 60:12075-12084
Using the Pictet–Spengler reactions of tryptophan with aldehydes under acidic conditions at ambient temperature, diastereoisomers of 1,3-disubstituted-1,2,3,4-tetrahydro-β-carbolines could readily be furnished in short time (0.5–4 h) with good t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6e218e5fb4d002af1c38261a1e80aa2
https://doi.org/10.1016/j.tet.2004.10.025
https://doi.org/10.1016/j.tet.2004.10.025
Autor:
Hsing Pang Hsieh, Fu Ming Kuo, Ming Yu Fang, Teng Kuang Yeh, Jim-Tong Horng, Ta Jen Lin, Shengkai Ko, Mohane Selvaraj Coumar, Shin-Ru Shih, Hui Chen Hung, Yu-Sheng Chao, Yen Chun Lee, Yu Lin Huang, Hui Yi Shiao, John T.A. Hsu, Jiann Yih Yeh
Publikováno v:
ChemMedChem. 7(9)
From a high-throughput screening (HTS) hit with inhibitory activity against virus-induced cytophathic in the low micromolar range, we have developed a potent anti-influenza lead through careful optimization without compromising the drug-like properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acede49520cce70e3e8b876f62807686
https://pubmed.ncbi.nlm.nih.gov/22821876
https://pubmed.ncbi.nlm.nih.gov/22821876
Autor:
John T.A. Hsu, In Chun Chen, Jiann Yih Yeh, Fu Ming Kuo, Shin-Ru Shih, Wen Fang Tang, Hsing Pang Hsieh, Chun Wei Chang, Sung Nain Tseng, Mohane Selvaraj Coumar, Chi Jene Chen, Yu-Sheng Chao, Chun-Chen Liao, Hui Ling Lee, Jim-Tong Horng, HY Shiao
Publikováno v:
Journal of medicinal chemistry. 53(4)
By using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza A (H1N1) virus induced cytopathic effect in Madin-Darby canine kidney cell culture in low micromolar range. Detailed structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271727769090c4fd175cf3f734e23654
https://pubmed.ncbi.nlm.nih.gov/20092255
https://pubmed.ncbi.nlm.nih.gov/20092255
Autor:
Chin Yu Lin, Jang Yang Chang, Ching Ping Chen, Chiung-Tong Chen, Ying Jun Chen, Hsing Pang Hsieh, Ching Chuan Kuo, Fu Ming Kuo, Jing Ping Liou, Uan Kang Tan, Su Ying Wu, Hsu Yi Sun, Chang Ying Chu, Yu-Shan Wu, Hsien-Tsung Yao, Yi Kun Chiang, Teng Kuang Yeh, Chia Ling Hsiao, Mohane Selvaraj Coumar, Chi Yen Chang
Publikováno v:
Journal of medicinal chemistry. 52(15)
BPR0L075 (2) is a potential anticancer drug candidate designed from Combretastatin A-4 (1) based on the bioisosterism principle. Metabolites of 2, proposed from in vitro human microsome studies, were synthesized, leading to the identification of meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537ac34fa49b095db12ac1bad9a25dcd
https://pubmed.ncbi.nlm.nih.gov/19586033
https://pubmed.ncbi.nlm.nih.gov/19586033
Publikováno v:
ChemInform. 36
Using the Pictet–Spengler reactions of tryptophan with aldehydes under acidic conditions at ambient temperature, diastereoisomers of 1,3-disubstituted-1,2,3,4-tetrahydro-β-carbolines could readily be furnished in short time (0.5–4 h) with good t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2975879c315a51dfafd15f20443ba545
https://doi.org/10.1002/chin.200514160
https://doi.org/10.1002/chin.200514160
Autor:
Hsing Pang Hsieh, Shiow Ju Lee, Yi Ling Chang, Jang Yang Chang, Chun Wei Chang, Fu Ming Kuo, Jing Ping Liou, Yung Ning Yang, Chiung Chiu Wang, Huan Yi Tseng
Publikováno v:
Journal of medicinal chemistry. 47(17)
The synthesis and study of the structure-activity relationships of two new classes of synthetic antitubulin compounds based on 1-aroylindole and 3-aroylindole skeletons are described. Lead compounds 3, 10, and 14 displayed potent cytotoxicities with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30de400a8d9a293d2661da384e11aafc
https://pubmed.ncbi.nlm.nih.gov/15293996
https://pubmed.ncbi.nlm.nih.gov/15293996
Autor:
Chun Wei Chang, Chi Yen Chang, Jing Ping Liou, Fu Ming Kuo, Hsing Pang Hsieh, Neeraj Mahindroo, Jang Yang Chang
Publikováno v:
Journal of medicinal chemistry. 47(11)
A new series of 3-aminobenzophenone compounds as potent inhibitors of tubulin polymerization was discovered based on the mimic of the aminocombretastatin molecular skeleton. Lead compounds 5 and 11, with alkoxy groups at the C-4 position of B-ring, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1494e597e27b6580c48947cceec2ab
https://pubmed.ncbi.nlm.nih.gov/15139768
https://pubmed.ncbi.nlm.nih.gov/15139768