Zobrazeno 1 - 10
of 3 984
pro vyhledávání: '"Fu-An Li"'
Autor:
Yi-Cheng Chang, Hsiao-Lin Lee, Wenjin Yang, Meng-Lun Hsieh, Cai-Cin Liu, Tung-Yuan Lee, Jing-Yong Huang, Jiun-Yi Nong, Fu-An Li, Hsiao-Li Chuang, Zhi-Zhong Ding, Wei-Lun Su, Li-Yun Chueh, Yi-Ting Tsai, Che-Hong Chen, Daria Mochly-Rosen, Lee-Ming Chuang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydroxynonenal. A missense Glu504Lys mutati
Externí odkaz:
https://doaj.org/article/aa0c7baef0c6434fba0dad49f77f4be3
Autor:
Siow-Wey Hee, Yi-Cheng Chang, Lynn Su, Ing-Jung Chen, Yung-Ming Jeng, Meng-Lun Hsieh, Yu-Chia Chang, Fu-An Li, Daniel Liao, Shiau-Mei Chen, Lee-Ming Chuang
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107997- (2023)
Summary: 15-keto-PGE2 is one of the eicosanoids with anti-inflammatory properties. In this study, we demonstrated that 15-keto-PGE2 post-translationally modified the nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) subunits p105/p
Externí odkaz:
https://doaj.org/article/412f87713f30478d98d29cbdcee7fa14
Autor:
Kai-Hsuan Wang, Jing-Yang Chang, Fu-An Li, Kuan-Yi Wu, Shu-Hao Hsu, Yen-Ju Chen, Tse-Ling Chu, Jessica Lin, Hong-Ming Hsu
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Cytoadherence and migration are crucial for pathogens to establish colonization in the host. In contrast to a nonadherent isolate of Trichomonas vaginalis, an adherent one expresses more actin-related machinery proteins with more active flag
Externí odkaz:
https://doaj.org/article/a0845fe6e27543aab897e30daa81f339
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-18 (2022)
Abstract Background We recently showed that fucosyltransferase 8 (FUT8)-mediated core fucosylation of transforming growth factor-β receptor enhances its signaling and promotes breast cancer invasion and metastasis. However, the complete FUT8 target
Externí odkaz:
https://doaj.org/article/60314cc7a70a412882c45c08bb050d3e
Autor:
Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Chien-Chin Lin, Wei-Ju Liao, Fu-An Li, Ling-Hui Li, Kurt Yun Mou, Steve R. Roffler, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang
Publikováno v:
Haematologica, Vol 108, Iss 5 (2022)
A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia that offers an opportunity for targeted therapy is addiction to protein tyrosine kinase signaling. One such signal is the receptor tyrosine kinase Fms-like receptor t
Externí odkaz:
https://doaj.org/article/d8f955e1c015423ea6018dcfad0ba05e
Autor:
Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker, Lee-Young Chau
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)
Abstract Background The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expres
Externí odkaz:
https://doaj.org/article/2f0f3b273fa448dba3cf937927f8cb07
Autor:
Janaki N. Sudhakar, Hsueh-Han Lu, Hung-Yu Chiang, Ching-Shu Suen, Ming-Jing Hwang, Sung-Yu Wu, Chia-Ning Shen, Yao-Ming Chang, Fu-An Li, Fu-Tong Liu, Jr-Wen Shui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Galectins are carbohydrate binding proteins previously implicated in sensing and repairing damaged lysosomes. Here, the authors show that galectin-9 has specific lysosomal roles in autophagy and contributes to cell degeneration and apoptosis in colit
Externí odkaz:
https://doaj.org/article/79593cb82cac49f1bc288649e78208de
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-18 (2020)
Abstract Background Serglycin (SRGN), previously recognized as an intracellular proteoglycan involved in the storage processes of secretory granules, has recently been shown to be upregulated in several solid tumors. We have previously shown that SRG
Externí odkaz:
https://doaj.org/article/f35c09d5df52404ba9bc239716e5061f
Autor:
Hsiang-Chi Huang, Yun-Ju Lai, Chun-Che Liao, Wang-Feng Yang, Ke-Bin Huang, I-Jung Lee, Wen-Cheng Chou, Shih-Han Wang, Ling-Hui Wang, Jung-Mao Hsu, Cheng-Pu Sun, Chun-Tse Kuo, Jyun Wang, Tzu-Chun Hsiao, Po-Jiun Yang, Te-An Lee, Wilson Huang, Fu-An Li, Chen-Yang Shen, Yi-Ling Lin, Mi-Hua Tao, Chia-Wei Li
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103712- (2021)
Background: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and vaccines has been compromised by rapidly spreading SARS-CoV-2 variants. Viruses can hijack the glycosylation machinery of host cells to sh
Externí odkaz:
https://doaj.org/article/8fed32a6141e421c81852255ebc22345
Autor:
Shuo-Ming Ou, Ming-Tsun Tsai, Huan-Yuan Chen, Fu-An Li, Wei-Cheng Tseng, Kuo-Hua Lee, Fu-Pang Chang, Yao-Ping Lin, Ruey-Bing Yang, Der-Cherng Tarng
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Background: Galectin-3 (Gal-3) is a multifunctional glycan-binding protein shown to be linked to chronic inflammation and fibrogenesis. Plasma Gal-3 is associated with proteinuria and renal dysfunction, but its role has never been confirmed with kidn
Externí odkaz:
https://doaj.org/article/56cb477fab1946c390ed0f1710c1d258