Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Fu Sheng Shen"'
Publikováno v:
Journal of Biological Chemistry. 268:24910-24915
The biosynthesis of the prohormone convertase PC2 was studied in Chinese hamster ovary cells stably transfected with PC2 cDNA (CHO/PC2) and in rat insulinoma cells (Rin5f). The major form of PC2 synthesized by CHO/PC2 cells was a 75-kDa protein corre
Autor:
Robert B. Mackin, Tiffany Adams, Savita Dhanvantari, Chun-Fa Zhang, Stephen J. Morris, Fu Sheng Shen, Christopher R. Snell, Y. Peng Loh
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 17(9)
In familial hyperproinsulinemia, specific mutations in the proinsulin gene are linked with a profound increase in circulating plasma proinsulin levels. However, the molecular and cellular basis for this disease remains uncharacterized. Here we invest
Autor:
Ying Zhang, Emmanuel Normant, Lewis K. Pannell, Fu-sheng Shen, David R Cool, Y. Peng Loh, Hao-Chia Chen
Publikováno v:
Cell. 88(1)
A proposed mechanism for sorting secretory proteins into granules for release via the regulated secretory pathway in endocrine-neuroendocrine cells involves binding the proteins to a sorting receptor at the trans -Golgi network, followed by budding a
Publikováno v:
The Journal of biological chemistry. 270(9)
The human immunodeficiency virus type 1 internal structural protein precursor, p55, and its corresponding matrix proteolytic fragment, p17, are phosphorylated at Ser111 by protein kinase C. COS-7 cells transfected with plasmids encoding either the wi
Publikováno v:
Journal of Biological Chemistry. 264:15600-15605
A putative processing enzyme for proenkephalin, with activity directed toward basic residues, was purified over 2000-fold from washed bovine adrenal medullary chromaffin granule membranes. The molecular mass of this membrane-bound adrenal trypsin-lik