Zobrazeno 1 - 10
of 3 911
pro vyhledávání: '"FtD"'
Autor:
Yuka Koike
Publikováno v:
Neuroscience Research, Vol 208, Iss , Pp 1-7 (2024)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by nuclear depletion and cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43). TDP-43 plays a key role in regulating the splicing of numerous genes, inc
Externí odkaz:
https://doaj.org/article/b7cdb22ca57f4fe5876cca077e0710f7
Autor:
Masatsune Shibutani, Hideki Tanda, Yuki Seki, Shinichiro Kashiwagi, Tsuyoshi Nishiyama, Yasuhiro Fukui, Daiki Imanishi, Hiroaki Kasashima, Tatsunari Fukuoka, Kiyoshi Maeda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract In later-line treatment of metastatic colorectal cancer (mCRC), there may be large differences in treatment efficacy depending on cancer cachexia. Recently, the cachexia index (CXI), which was calculated from the skeletal muscle mass index (
Externí odkaz:
https://doaj.org/article/b132e705a64944378bd7831df2504c54
Publikováno v:
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 60, Iss 1, Pp 1-8 (2024)
Abstract Background Cognitive and behavioral changes in ALS are featured as an integral part of the disease. A noticeable proportion of ALS patients present with a full-blown picture of frontotemporal dementia, which is considered the most common for
Externí odkaz:
https://doaj.org/article/edec3c3647c6408e8ad567cf850d65a0
Autor:
Confidence Raymond, Dong Zhang, Jorge Cabello, Linshan Liu, Paulien Moyaert, Jorge G. Burneo, Michael O. Dada, Justin W. Hicks, Elizabeth Finger, Andrea Soddu, Andrea Andrade, Michael T. Jurkiewicz, Udunna C. Anazodo
Publikováno v:
Frontiers in Nuclear Medicine, Vol 4 (2024)
IntroductionIn Positron Emission Tomography (PET) imaging, the use of tracers increases radioactive exposure for longitudinal evaluations and in radiosensitive populations such as pediatrics. However, reducing injected PET activity potentially leads
Externí odkaz:
https://doaj.org/article/8d21803a170c4e2981c0fe4b52c0a764
Autor:
Juan I. López-Carbonero, Irene García-Toledo, Laura Fernández-Hernández, Pablo Bascuñana, María J. Gil-Moreno, Jordi A. Matías-Guiu, Silvia Corrochano
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that share the presence of aberrant, misfolded and mislocalized deposits of the protein TDP-43, as in the case of amyotrophic lateral sclerosis and some, but not
Externí odkaz:
https://doaj.org/article/e463fc941f6c458eb3db83c652187611
Autor:
Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Camille Noiray, Stéphane Lehericy, Romain Valabrègue, Fabien Caillé, Philippe Gervais, Martin Moussion, Michel Bottlaender, Marie Sarazin
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background The locus coeruleus (LC) and the nucleus basalis of Meynert (NBM) are altered in early stages of Alzheimer’s disease (AD). Little is known about LC and NBM alteration in limbic-predominant age-related TDP-43 encephalopathy (LATE
Externí odkaz:
https://doaj.org/article/283489cd1ad14008b765a46806349f86
Autor:
Riccardo Sirtori, Michelle J. Gregoire, Emily M. Potts, Alicia Collins, Liviana Donatelli, Claudia Fallini
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emer
Externí odkaz:
https://doaj.org/article/8b88ef704fdc41188bda66bde4715d39
Autor:
James W. Gilbert, Zachary Kennedy, Bruno M.D.C. Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, David Cooper, Ken Yamada, Matthew Hassler, Hélène Tran, Fen Biao Gao, Robert H. Brown, Jr., Anastasia Khvorova
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102291- (2024)
A hexanucleotide (G4C2) repeat expansion (HRE) within intron one of C9ORF72 is the leading genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). C9ORF72 haploinsufficiency, formation of RNA foci, and production of di
Externí odkaz:
https://doaj.org/article/48f420ec0d5f4364889fb47b75a6618c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Heterozygous loss-of-function mutations in the GRN gene are a common cause of frontotemporal dementia. Such mutations lead to decreased plasma and cerebrospinal fluid levels of progranulin (PGRN), a neurotrophic factor with lysosomal functions. Sorti
Externí odkaz:
https://doaj.org/article/5c802213e9ef44b4ba45e804beb97a92