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Computer-aided molecular modeling, synthesis, and biological evaluation of 8-(benzyloxy)-2-phenylpyrazolo[4,3-c]quinoline as a novel benzodiazepine receptor agonist ligand

Autor: Thierry Langer, Zi Qiang Gu, Skolnick P, Fryer Ri, Kamath Pg, Wang Cg

Publikováno v: Journal of medicinal chemistry. 38(6)

Using computer-aided conformational analysis, based on molecular dynamics simulation, cluster analysis, and Monte Carlo techniques, we have designed and synthesized compounds in which a benzyloxy substituent has been incorporated into a series of pyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7113496c41f71ef9c4ad3a24a3e9d36
https://pubmed.ncbi.nlm.nih.gov/7699711

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2-Benzazepines. [1,2,3]Triazolo[4,5-d][2]benzazepines and dibenzo[c,f][1,2,3]triazolo[3,4-a]azepines. Synthesis and evaluation as central nervous system agents

Autor: Armin Walser, Fryer Ri, Lorna Smith Benjamin, Eugene John Trybulski, S. Vitone

Publikováno v: Journal of Medicinal Chemistry. 26:367-372

The facile synthesis of [1,2,3]triazolo((4,5-d][2]benzazepines and dibenzo[c,f][1,2,3]triazolo[3,4-a]azepines by the addition of sodium azide to acetylenic benzophenones is described. Examination of the pharmacological data indicates that selected tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b7946a0446655c82e7a6245d96e584c
https://doi.org/10.1021/jm00357a011

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2-benzazepines. 5. Synthesis of pyrimido[5,4-d][2]benzazepines and their evaluation as anxiolytic agents

Autor: Armin Walser, Fryer Ri, W. D. Horst, Louis E. Benjamin, J. Sepinwall, Eugene John Trybulski, Norman W. Gilman, Reeder E, A. B. Davidson, Earley Jv

Publikováno v: Journal of medicinal chemistry. 26(11)

A series of 5H-pyrimido[5,4-d][2]benzazepines has been synthesized, starting from the corresponding 2-benzazepin-5-ones, and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca52361a2cd84d4f0f56b1d4278f2be3
https://pubmed.ncbi.nlm.nih.gov/6138436

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ChemInform Abstract: 2-BENZAZEPINES. 6. SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF THE METABOLITES OF 9-CHLORO-7-(2-CHLOROPHENYL)-5H-PYRIMIDO(5,4-D)(2)BENZAZEPINE

Autor: Armin Walser, John F. Blount, Fryer Ri, Reeder E, Eugene John Trybulski

Publikováno v: Chemischer Informationsdienst. 15

The 2-benzazepine 9-chloro-7-(2-chlorophenyl)-5H-pyrimido[5,4-d] [2]benzazepine (1) has been selected for development as an anxiolytic agent. In support of this program, we have confirmed by chemical synthesis the structures of three in vitro (rat li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e1ce6b0dce08dca5569284d007be294
https://doi.org/10.1002/chin.198415258

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2-benzazepines. 6. Synthesis and pharmacological properties of the metabolites of 9-chloro-7-(2-chlorophenyl)-5H-pyrimido[5,4-d] [2]benzazepine

Autor: Reeder E, John F. Blount, Armin Walser, Eugene John Trybulski, Fryer Ri

Publikováno v: Journal of medicinal chemistry. 26(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7475c09d2e7d39ee41c9aabf6f14ecc
https://pubmed.ncbi.nlm.nih.gov/6138437

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