Organization of ATP-gated P2X1 receptor intracellular termini in apo and desensitized states.

Autor: Fryatt AG; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK., Dayl S; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.; Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq., Stavrou A; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK., Schmid R; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, UK., Evans RJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK rje6@le.ac.uk.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2019 Feb 04; Vol. 151 (2), pp. 146-155. Date of Electronic Publication: 2019 Jan 09.

Mechanistic insights from resolving ligand-dependent kinetics of conformational changes at ATP-gated P2X1R ion channels.

Autor: Fryatt AG; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom., Dayl S; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom.; Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq., Cullis PM; Department of Chemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom., Schmid R; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom.; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom., Evans RJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom.

Publikováno v: Scientific reports [Sci Rep] 2016 Sep 12; Vol. 6, pp. 32918. Date of Electronic Publication: 2016 Sep 12.

P2X receptor chimeras highlight roles of the amino terminus to partial agonist efficacy, the carboxyl terminus to recovery from desensitization, and independent regulation of channel transitions.

Autor: Allsopp RC; From the Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom., Farmer LK; From the Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom., Fryatt AG; From the Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom., Evans RJ; From the Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom. Electronic address: rje6@le.ac.uk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2013 Jul 19; Vol. 288 (29), pp. 21412-21421. Date of Electronic Publication: 2013 Jun 05.

Voltage-gated sodium channel expression in rat spiral ganglion neurons.

Autor: Fryatt AG; Department of Cell Physiology and Pharmacology, University of Leicester, University Road, Leicester LE19HN, UK. agf4@le.ac.uk, Vial C, Mulheran M, Gunthorpe MJ, Grubb BD

Publikováno v: Molecular and cellular neurosciences [Mol Cell Neurosci] 2009 Dec; Vol. 42 (4), pp. 399-407. Date of Electronic Publication: 2009 Sep 16.