Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma.

Autor: Tempora P; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., D'Amico S; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Gragera P; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Damiani V; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Krol K; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Scaldaferri V; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Pandey K; Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia., Chung S; Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia., Lucarini V; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Giorda E; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Scarsella M; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Volpe G; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Pezzullo M; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., De Stefanis C; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., D'Oria V; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., De Angelis L; Plaisant Polo Tecnologico S.R.L, Castel Romano, Rome, Italy., Giovannoni R; Department of Biology, Genetic Unit, University of Pisa, Pisa, Italy., De Ioris MA; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Melaiu O; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., Purcell AW; Department of Biochemistry and Molecular Biology, Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia., Locatelli F; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Department of Life Sciences, Catholic University of the Sacred Heart, Rome, Italy., Fruci D; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. doriana.fruci@opbg.net.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Oct 22; Vol. 43 (1), pp. 292. Date of Electronic Publication: 2024 Oct 22.

From the identification of actionable molecular targets to the generation of faithful neuroblastoma patient-derived preclinical models.

Autor: Capasso M; Department of Medical Biotechnology, University of Naples Federico II, 80138, Naples, Italy.; CEINGE Advanced Biotecnology, 80138, Naples, Italy., Brignole C; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy., Lasorsa VA; CEINGE Advanced Biotecnology, 80138, Naples, Italy., Bensa V; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy., Cantalupo S; Department of Medical Biotechnology, University of Naples Federico II, 80138, Naples, Italy.; CEINGE Advanced Biotecnology, 80138, Naples, Italy., Sebastiani E; CIBIO, University of Trento, 38122, Trento, Italy., Quattrone A; CIBIO, University of Trento, 38122, Trento, Italy., Ciampi E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy., Avitabile M; Department of Medical Biotechnology, University of Naples Federico II, 80138, Naples, Italy.; CEINGE Advanced Biotecnology, 80138, Naples, Italy., Sementa AR; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Mazzocco K; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Cafferata B; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Gaggero G; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Vellone VG; Pathological Anatomy, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Cilli M; Animal Facility, IRCCS Policlinico San Martino, 16100, Genoa, Italy., Calarco E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy., Giusto E; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy., Perri P; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy., Aveic S; Pediatric Research Institute Città Della Speranza, 35127, Padua, Italy., Fruci D; Department of Emato-Oncology, Bambino Gesù Children's Hospital, 00146, -Rome, Italy., Tondo A; Department of Emato-Oncology, Anna Meyer Children's Hospital, 50139, Florence, Italy., Luksch R; Emato-Oncology Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy., Mura R; Emato-Oncology Unit, Azienda Ospedaliera Brotzu, 09047, Cagliari, Italy., Rabusin M; Pediatric Department, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137, Trieste, Italy., De Leonardis F; Department of Pediatric Oncology, Polyclinic Hospital, 70124, Bari, Italy., Cellini M; Emato-Oncology Unit, University-Hospital Polyclinic of Modena, 41124, Modena, Italy., Coccia P; University-Hospital of Marche, Presidio Ospedaliero 'G. Salesi', 60126, Ancona, Italy., Iolascon A; Department of Medical Biotechnology, University of Naples Federico II, 80138, Naples, Italy.; CEINGE Advanced Biotecnology, 80138, Naples, Italy., Corrias MV; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy., Conte M; Clinical Oncology Unit, IRCCS Istituto Giannina Gaslini, 16147, -Genoa, Italy., Garaventa A; Clinical Oncology Unit, IRCCS Istituto Giannina Gaslini, 16147, -Genoa, Italy., Amoroso L; Clinical Oncology Unit, IRCCS Istituto Giannina Gaslini, 16147, -Genoa, Italy., Ponzoni M; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy. mircoponzoni@gaslini.org., Pastorino F; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, Genoa, Italy.

Publikováno v: Journal of translational medicine [J Transl Med] 2024 Feb 13; Vol. 22 (1), pp. 151. Date of Electronic Publication: 2024 Feb 13.

Nutlin-3a Enhances Natural Killer Cell-Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors.

Autor: Veneziani I; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Infante P; Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy., Ferretti E; Department of Experimental Medicine, University of Genoa, Genova, Italy.; Centre of Excellence for Biomedical Research, University of Genoa, Genova, Italy., Melaiu O; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Battistelli C; Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Lucarini V; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Compagnone M; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Nicoletti C; Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.; DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy., Castellano A; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Petrini S; Confocal Microscopy, Core Facility, Research Laboratories, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Ognibene M; Laboratorio Cellule Staminali Post Natali e Terapie Cellulari, IRCCS Giannina Gaslini Institute, Genoa, Italy., Pezzolo A; Laboratorio Cellule Staminali Post Natali e Terapie Cellulari, IRCCS Giannina Gaslini Institute, Genoa, Italy., Di Marcotullio L; Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Bei R; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata,' Rome, Italy., Moretta L; Department of Immunology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Pistoia V; Department of Immunology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Fruci D; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy., Barnaba V; Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.; Cellular and Molecular Immunology Unit, Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Sapienza University of Rome, Rome, Italy., Locatelli F; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.; Department of Pediatrics, Sapienza University of Rome, Rome, Italy., Cifaldi L; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy. cifaldi@med.uniroma2.it.; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata,' Rome, Italy.; Academic Department of Pediatrics (DPUO), Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2021 Feb; Vol. 9 (2), pp. 170-183. Date of Electronic Publication: 2020 Dec 10.

Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma.

Autor: Lucarini V; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy., Melaiu O; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., D'Amico S; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy., Pastorino F; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Tempora P; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy., Scarsella M; Flow Cytometry Core Facility, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy., Pezzullo M; Research Laboratories, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy., De Ninno A; CNR Institute for Photonics and Nanotechnology, Rome, 00156, Italy., D'Oria V; Confocal Microscopy Core Facility, Research Center, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy., Cilli M; IRCCS Ospedale Policlinico San Martino, Animal Facility, 16132, Genoa, Italy., Emionite L; IRCCS Ospedale Policlinico San Martino, Animal Facility, 16132, Genoa, Italy., Infante P; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., Di Marcotullio L; Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy., De Ioris MA; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy., Barillari G; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., Alaggio R; Pathology Unit, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy., Businaro L; CNR Institute for Photonics and Nanotechnology, Rome, 00156, Italy., Ponzoni M; Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Locatelli F; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, 00168, Rome, Italy., Fruci D; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146, Rome, Italy. doriana.fruci@opbg.net.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Nov 17; Vol. 41 (1), pp. 326. Date of Electronic Publication: 2022 Nov 17.

Targeting the antigen processing and presentation pathway to overcome resistance to immune checkpoint therapy.

Autor: D'Amico S; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy., Tempora P; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy., Melaiu O; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy., Lucarini V; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy., Cifaldi L; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Academic Department of Pediatrics (DPUO), Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy., Locatelli F; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.; Catholic University of the Sacred Heart, Rome, Italy., Fruci D; Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Jul 22; Vol. 13, pp. 948297. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).