Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Frosty Loechel"'
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 11:537-544
Multiplexing of GFP based and immunofluorescence translocation assays enables easy acquisition of multiple readouts from the same cell in a single assay run. Immunofluorescence assays monitor translocation, phosphorylation, and up/down regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd36e8d9a02655a6f25f2fdb1b1c4045
https://doi.org/10.2174/138620708785204081
https://doi.org/10.2174/138620708785204081
Autor:
Lisbeth Elster, Stephen P. Watson, Christiane Volbracht, Frosty Loechel, Ib Vestergaard Klewe, Laurent David, Suresh Poda, Thomas Jensen, Søren Møller Nielsen
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(22)
The identification of the novel and selective GPR3 inverse agonist AF64394, the first small molecule inhibitor of GPR3 receptor function, is described. Structure activity relationships and syntheses based around AF64394 are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a460f9a5cdfb4be4b18144ac54645127
https://pubmed.ncbi.nlm.nih.gov/25442311
https://pubmed.ncbi.nlm.nih.gov/25442311
Publikováno v:
European Journal of Biochemistry. 268:3797-3806
The laminin β2 chain is a basement membrane component expressed in a tissue- and developmental stage-specific manner. In this report we have examined the transcriptional and post-transcriptional regulation of the human laminin β2 chain in human tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dccc0d675b7e2096eb052f052f46de47
https://doi.org/10.1046/j.1432-1327.2001.02292.x
https://doi.org/10.1046/j.1432-1327.2001.02292.x
Publikováno v:
Biochemical and Biophysical Research Communications. 275:261-267
We have investigated the trafficking of the membrane-anchored form of human ADAM 12 (ADAM 12-L) fused to a green fluorescence protein tag. Subcellular localization of the protein in transiently transfected cells was determined by fluorescence microsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71fa2ac30ab8f2ccc6d9e1e07268c6d
https://doi.org/10.1006/bbrc.2000.3295
https://doi.org/10.1006/bbrc.2000.3295
Autor:
Reidar Albrechtsen, Kousuke Iba, J K Langford, Ralph D. Sanderson, Brent Gilpin, Camilla Fröhlich, Ulla M. Wewer, K Ishiguro, Frosty Loechel, A Zolkiewska, Cord Brakebusch, T Kojima, Reinhard Fässler, Wei Liu
Publikováno v:
Journal of Cell Biology. 149:1143-1156
The ADAMs (a disintegrin and metalloprotease) family of proteins is involved in a variety of cellular interactions, including cell adhesion and ecto- domain shedding. Here we show that ADAM 12 binds to cell surface syndecans. Three forms of recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e03e94e08c3049e9d35856ba61d4c542
https://doi.org/10.1083/jcb.149.5.1143
https://doi.org/10.1083/jcb.149.5.1143
Publikováno v:
Journal of Biological Chemistry. 274:13427-13433
The ADAMs (a disintegrinand metalloprotease) are a family of multidomain proteins that are believed to play key roles in cell-cell and cell-matrix interactions. We have shown recently that human ADAM 12-S (meltrin α) is an active metalloprotease. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8c0867052aec97fc6dd3cd7ec9b4480
https://doi.org/10.1074/jbc.274.19.13427
https://doi.org/10.1074/jbc.274.19.13427
Autor:
Marie-Geneviève Mattei, Ulla M. Wewer, Brent Gilpin, Eva Engvall, Frosty Loechel, Reidar Albrechtsen
Publikováno v:
Journal of Biological Chemistry. 273:157-166
The ADAM (A Disintegrin And Metalloprotease) family of cell-surface proteins may have an important role in cellular interactions and in modulating cellular responses. In this report we describe a novel, secreted form of human ADAM 12 (meltrin alpha),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e8b38dddb040ee32fae2c46b564276
https://doi.org/10.1074/jbc.273.1.157
https://doi.org/10.1074/jbc.273.1.157
Autor:
Pierre H. Vachon, K Arahata, John C. Reed, Frosty Loechel, Eva Engvall, Yukiko K. Hayashi, Huaxi Xu, Ulla M. Wewer, Ling Liu
Publikováno v:
Journal of Clinical Investigation. 100:1870-1881
Mutations in genes coding for dystrophin, for alpha, beta, gamma, and delta-sarcoglycans, or for the alpha2 chain of the basement membrane component merosin (laminin-2/4) cause various forms of muscular dystrophy. Analyses of integrins showed an abno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f3464ad90f52b69d63663123bae273
https://doi.org/10.1172/jci119716
https://doi.org/10.1172/jci119716
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 356
This chapter describes the design and development of cell-based assays, in which quantitation of the intracellular translocation of a target protein--rather than binding or catalytic activity--provides the primary assay readout. These are inherently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16c83ad33de9c1b9fee9721a4b5cd073
https://pubmed.ncbi.nlm.nih.gov/16988419
https://pubmed.ncbi.nlm.nih.gov/16988419
This chapter describes the design and development of cell-based assays, in which quantitation of the intracellular translocation of a target protein--rather than binding or catalytic activity--provides the primary assay readout. These are inherently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f87e54ad19efe338dce871cda5f3c11
https://doi.org/10.1385/1-59745-217-3:401
https://doi.org/10.1385/1-59745-217-3:401
