Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Frontotemporal dementia and parkinsonism linked to chromosome 17"'
Autor:
Manuel Schweighauser, Alexey G. Murzin, Jennifer Macdonald, Isabelle Lavenir, R. Anthony Crowther, Sjors H.W. Scheres, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-
Externí odkaz:
https://doaj.org/article/43edd87f5ecc46a6b3d9100ebbe7d73f
Akademický článek
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Publikováno v:
Neurobiology of Disease, Vol 125, Iss , Pp 232-244 (2019)
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ) and hyperphosphorylated Tau protein (P-Tau). Our recent data showed a differential accumulation of Tau protein phosphorylated at residue Thr231 (pThr231) in dis
Externí odkaz:
https://doaj.org/article/f5e7bad8aa5f4cb38f17b47632e64f20
Akademický článek
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Autor:
Lindsay A. Welikovitch, A. Claudio Cuello, Sonia Do Carmo, Hélène Hall, Lionel Breuillaud, Jennifer A. Macdonald, Janice C. Malcolm, Michel Goedert
Publikováno v:
Neurobiology of Disease
Neurobiology of Disease, Vol 127, Iss, Pp 323-338 (2019)
Neurobiology of Disease, Vol 127, Iss, Pp 323-338 (2019)
The assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. Se
Akademický článek
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Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics
Frontiers in Genetics
Alternative splicing is a fundamental mechanism of eukaryotic RNA regulation that increases the transcriptomic and proteomic complexity within an organism. Moreover, alternative splicing provides a framework for generating unique yet complex tissue-
Autor:
Measho Abreha, Allan I. Levey, Shamsideen A. Ojelade, Duc M. Duong, Zachary T. McEachin, Gary J. Bassell, Eric B. Dammer, Nicholas T. Seyfried, James J. Lah, Joshua M. Shulman, Marla Gearing
Publikováno v:
The Journal of Biological Chemistry
One of the defining pathological features of Alzheimer’s Disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD has been suggested to enhance phosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f79bdc687578d84246e18e1f234fa5
https://doi.org/10.1101/2020.06.17.157552
https://doi.org/10.1101/2020.06.17.157552
Autor:
Nobutaka Hattori, Kenya Nishioka, Hiroyo Yoshino, Yuji Ueno, Yuanzhe Li, Tetsuya Suhara, Makoto Higuchi, Manabu Funayama, Masashi Takanashi, Taku Hatano, Aya Ikeda, Arisa Hayashida, Hitoshi Shimada, Naruhiko Sahara
Publikováno v:
Movement Disorders
Background While mechanistic links between tau abnormalities and neurodegeneration have been proven in frontotemporal dementia and parkinsonism linked to chromosome 17 caused by MAPT mutations, variability of the tau pathogenesis and its relation to
Autor:
Yamini Mutreja, Mel B. Feany, T. Chris Gamblin, Mythili Yenjerla, Liqun Wang, Farah H. Bardai
Publikováno v:
The Journal of Neuroscience. 38:108-119
The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau.In vitro, FTDP-17 mutant ver