Zobrazeno 1 - 10
of 534
pro vyhledávání: '"Fronto-temporal dementia"'
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-6 (2023)
Abstract Background Fronto-Temporal Dementia (FTD) is a neurodegenerative disorder featuring frontotemporal lobe atrophy which leads to profound changes in behavior and cognition in the affected subjects. Considering that the onset of this type of de
Externí odkaz:
https://doaj.org/article/9c20344dfcd549cdbf76a02398839415
Autor:
Min Chu, Lulu Wen, Deming Jiang, Li Liu, Haitian Nan, Ailing Yue, Yingtao Wang, Yihao Wang, Miao Qu, Ningqun Wang, Liyong Wu
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Background Neuroinflammation plays a significant role in the progression of frontotemporal dementia (FTD). However, the association between peripheral inflammatory factors and brain neurodegeneration is poorly understood. We aimed to examine
Externí odkaz:
https://doaj.org/article/0f9c8328666e421bb11861be87f390c7
Akademický článek
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Autor:
A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-33 (2022)
Abstract Background Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function and memory in
Externí odkaz:
https://doaj.org/article/07d99d58976b4e01996ddce1ebeeb842
Autor:
Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-14 (2021)
Abstract Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likely to be a major culprit in the t
Externí odkaz:
https://doaj.org/article/99efacbef7004ce6bd0c304590be3071
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
The microtubule-associated protein tau (MAPT) plays an important role in Alzheimer’s disease and primary tauopathy diseases. The abnormal accumulation of tau contributes to the development of neurotoxicity, inflammation, neurodegeneration, and cogn
Externí odkaz:
https://doaj.org/article/b5e3db0362c64d3e8f384c28559fbd06
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jana Riehl, Ramesh Rijal, Leonie Nitz, Christoph S. Clemen, Andreas Hofmann, Ludwig Eichinger
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The abundant homohexameric AAA + ATPase p97 (also known as valosin-containing protein, VCP) is highly conserved from Dictyostelium discoideum to human and a pivotal factor of cellular protein homeostasis as it catalyzes the unfolding of proteins. Owi
Externí odkaz:
https://doaj.org/article/001bb8bd10004d5ca23ec3f7bb2cbecf
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
ObjectiveTranscranial direct current stimulation (tDCS) has shown promising results when used as an adjunct to behavioral training in neurodegenerative diseases. However, the underlying neural mechanisms are not understood and neuroimaging evidence f
Externí odkaz:
https://doaj.org/article/f89584b9c8fc41aea396d7706b7e9a72
Autor:
Parijat Roy, Prashant Chaudhari, Heena Merchant-Pandit, Nilesh Shah, Sagar Karia, Avinash De Sousa
Publikováno v:
Telangana Journal of Psychiatry, Vol 6, Iss 1, Pp 99-101 (2020)
Dementia as a diagnosis at any age is a clinical challenge in psychiatric practice. In recent research reports there have been many case series and anecdotal case reports of dementia with an onset below the age of 45 years. In this case report, we pr
Externí odkaz:
https://doaj.org/article/316c99d6ac9a42eca137640fb8ad5566