Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Frontal Lobe/metabolism"'
Autor:
Jens Hjerling-Leffler, Julien Bryois, Patrick F. Sullivan, Jonathan R. I. Coleman, Jeanne E. Savage, Sten Linnarsson, Ana B. Muñoz-Manchado, Greg E. Crawford, Gerome Breen, Robert Plomin, Helena Gaspar, Nathan G. Skene, Danielle Posthuma, Philip R. Jansen
Publikováno v:
Molecular Psychiatry, 24(2), 182-197. Nature Publishing Group
Molecular psychiatry, 24(2), 182-197. Nature Publishing Group
Coleman, J R I, Bryois, J, Gaspar, H L A, Jansen, P R, Savage, J E, Skene, N, Plomin, R, Muñoz-Manchado, A B, Linnarsson, S, Crawford, G, Hjerling-Leffler, J, Sullivan, P F, Posthuma, D & Breen, G 2019, ' Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals ', Molecular Psychiatry, vol. 24, no. 2, pp. 182-197 . https://doi.org/10.1038/s41380-018-0040-6
Coleman, J, Bryois, J, Gaspar, H A, Jansen, P R, Savage, J E, Skene, N, Plomin, R, Muñoz-Manchado, A B, Linnarsson, S, Crawford, G, Hjerling-Leffler, J, Sullivan, P F, Posthuma, D & Breen, G 2019, ' Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals ', Molecular Psychiatry, vol. 24, no. 2, pp. 182–197 . https://doi.org/10.1038/s41380-018-0040-6
Coleman, J R I, Bryois, J, Gaspar, H A, Jansen, P R, Savage, J E, Skene, N, Plomin, R, Muñoz-Manchado, A B, Linnarsson, S, Crawford, G, Hjerling-Leffler, J, Sullivan, P F, Posthuma, D & Breen, G 2018, ' Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals ', Molecular Psychiatry, vol. 2018, no. 2, pp. 1-16 . https://doi.org/10.1038/s41380-018-0040-6
Molecular Psychiatry, 2018(2), 1-16. Nature Publishing Group
Molecular psychiatry, 24(2), 182-197. Nature Publishing Group
Coleman, J R I, Bryois, J, Gaspar, H L A, Jansen, P R, Savage, J E, Skene, N, Plomin, R, Muñoz-Manchado, A B, Linnarsson, S, Crawford, G, Hjerling-Leffler, J, Sullivan, P F, Posthuma, D & Breen, G 2019, ' Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals ', Molecular Psychiatry, vol. 24, no. 2, pp. 182-197 . https://doi.org/10.1038/s41380-018-0040-6
Coleman, J, Bryois, J, Gaspar, H A, Jansen, P R, Savage, J E, Skene, N, Plomin, R, Muñoz-Manchado, A B, Linnarsson, S, Crawford, G, Hjerling-Leffler, J, Sullivan, P F, Posthuma, D & Breen, G 2019, ' Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87 740 individuals ', Molecular Psychiatry, vol. 24, no. 2, pp. 182–197 . https://doi.org/10.1038/s41380-018-0040-6
Coleman, J R I, Bryois, J, Gaspar, H A, Jansen, P R, Savage, J E, Skene, N, Plomin, R, Muñoz-Manchado, A B, Linnarsson, S, Crawford, G, Hjerling-Leffler, J, Sullivan, P F, Posthuma, D & Breen, G 2018, ' Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals ', Molecular Psychiatry, vol. 2018, no. 2, pp. 1-16 . https://doi.org/10.1038/s41380-018-0040-6
Molecular Psychiatry, 2018(2), 1-16. Nature Publishing Group
Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate resu
Autor:
HUIN, Vincent, Deramecourt, Vincent, Caparros-Lefebvre, Dominique, Maurage, Claude-Alain, Duyckaerts, Charles, Kovari, Eniko, Pasquier, Florence, Buée-Scherrer, Valérie, Labreuche, Julien, Behal, Hélène, Buée, Luc, Dhaenens, Claire-Marie, Sablonnière, Bernard
Publikováno v:
Movement Disorders, Vol. 31, No 12 (2016) pp. 1883-1890
Movement Disorders
Movement Disorders, Wiley, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩
Movement Disorders
Movement Disorders, Wiley, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩
International audience; Background: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cf2cfca09d6c3801c9d118c5299515
http://arxiv.org/abs/2011.10447
http://arxiv.org/abs/2011.10447
Publikováno v:
Journal of neurochemistry, vol. 142, no. 5, pp. 767-775
Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative ef
Autor:
Alessandra Piersigilli, Sebastien Mosser, Michael Stumpe, Hermeto Gerber, Christine Goepfert, Joern Dengjel, Patrick C. Fraering, Benjamin Boury-Jamot, Urs Albrecht, Fulvio Magara
Publikováno v:
Acta Neuropathologica Communications
Gerber, Hermeto; Mosser, Sebastien; Boury-Jamot, Benjamin; Stumpe, Michael; Piersigilli, Alessandra; Göpfert, Christine; Dengjel, Joern; Albrecht, Urs; Magara, Fulvio; Fraering, Patrick C (2019). The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta neuropathologica communications, 7(1), p. 13. BioMed Central 10.1186/s40478-019-0660-3
Acta neuropathologica communications, vol. 7, no. 1, pp. 13
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Gerber, Hermeto; Mosser, Sebastien; Boury-Jamot, Benjamin; Stumpe, Michael; Piersigilli, Alessandra; Göpfert, Christine; Dengjel, Joern; Albrecht, Urs; Magara, Fulvio; Fraering, Patrick C (2019). The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta neuropathologica communications, 7(1), p. 13. BioMed Central 10.1186/s40478-019-0660-3
Acta neuropathologica communications, vol. 7, no. 1, pp. 13
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer’s disease
Autor:
Mizielinska, Sarah, Ridler, Charlotte E., Balendra, Rubika, Thoeng, Annora, Woodling, Nathan S., Grässer, Friedrich A., Plagnol, Vincent, Lashley, Tammaryn, Partridge, Linda, Isaacs, Adrian M.
Publikováno v:
Acta Neuropathol Commun
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-11 (2017)
Mizielinska, S, Ridler, C E, Balendra, R, Thoeng, A, Woodling, N S, Grässer, F A, Plagnol, V, Lashley, T, Partridge, L & Isaacs, A M 2017, ' Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration ', Acta Neuropathologica Communications, vol. 5, no. 1, 29 . https://doi.org/10.1186/s40478-017-0432-x
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-11 (2017)
Mizielinska, S, Ridler, C E, Balendra, R, Thoeng, A, Woodling, N S, Grässer, F A, Plagnol, V, Lashley, T, Partridge, L & Isaacs, A M 2017, ' Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration ', Acta Neuropathologica Communications, vol. 5, no. 1, 29 . https://doi.org/10.1186/s40478-017-0432-x
Acta Neuropathologica Communications
An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8cffffc8c9dbf8d06df8f513631ba9ec
https://hdl.handle.net/21.11116/0000-000B-4F59-A
https://hdl.handle.net/21.11116/0000-000B-4F59-A
Autor:
HUIN, Vincent, Deramecourt, Vincent, Caparros-Lefebvre, Dominique, Maurage, Claude-Alain, Duyckaerts, Charles, Kovari, Eniko, Pasquier, Florence, Buée-Scherrer, Valérie, Labreuche, Julien, Behal, Hélène, Buée, Luc, Dhaenens, Claire-Marie, Sablonnière, Bernard
Publikováno v:
Movement Disorders
Movement Disorders, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩
Movement Disorders, Wiley, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩
Movement Disorders, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩
Movement Disorders, Wiley, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩
International audience; Background: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5486e5a1d1f39ff8e610c1ac9455171a
https://hal.archives-ouvertes.fr/hal-03015965
https://hal.archives-ouvertes.fr/hal-03015965
Autor:
Fabienne Loup, Jean-Marc Fritschy, Heinz Gregor Wieser, Véronique M. André, Pierre Kehrli, Fabienne Picard, Yasuhiro Yonekawa
Publikováno v:
Brain, Vol. 129, No 12 (2006) pp. 3277-3289
Impaired transmission in GABAergic circuits is thought to contribute to the pathogenesis of epilepsy. Although it is well established that major reorganization of GABA(A) receptor subtypes occurs in the hippocampus of patients with medically refracto
Autor:
Stuart Pickering-Brown, William W. Seeley, Neill R. Graff-Radford, Jonathan D. Rohrer, Keith A. Josephs, John Collinge, David G. Munoz, Adrian M. Isaacs, Christine Van Broeckhoven, Harro Seelaar, Vivianna M. Van Deerlin, Ronald C. Petersen, Samir Kumar-Singh, John C. van Swieten, Simon Mead, Jeremy M Brown, Hazel Urwin, Han Xiang Deng, Joseph E. Parisi, Dennis W. Dickson, Astrid Authier, Peter Johannsen, Elizabeth M. C. Fisher, Charles L. White, David M. A. Mann, Ida E. Holm, Sebastiaan Engelborghs, Janice L. Holton, Ian R. A. Mackenzie, Shabnam Ghazi-Noori, Jørgen E. Nielsen, Martin N. Rossor, Gary Adamson, Bruce L. Miller, Manuela Neumann, Kimmo J. Hatanpaa, Jillian J. Kril, Tamas Revesz, Felix Geser, Rosa Rademakers, Julie van der Zee, Glenda M. Halliday, Eileen H. Bigio, John Q. Trojanowski, Myron F. Weiner, Peter Paul De Deyn, Valerie Doodeman
Publikováno v:
Urwin, H, Josephs, K A, Rohrer, J D, Mackenzie, I R, Neumann, M, Authier, A, Seelaar, H, van Swieten, J C, Brown, J M, Johannsen, P, Nielsen, J E, Holm, I E, Dickson, D W, Rademakers, R, Graff-Radford, N R, Parisi, J E, Petersen, R C, Hatanpaa, K J, White, C L, Weiner, M F, Geser, F, Van Deerlin, V M, Trojanowski, J Q, Miller, B L, Seeley, W W, van der Zee, J, Kumar-Singh, S, Engelborghs, S, de Deyn, P P, Van Broeckhoven, C, Bigio, E H, Deng, H X, Halliday, G M, Kril, J J, Munoz, D G, Mann, D M, Pickering-Brown, S M, Doodeman, V D, Adamson, G, Ghazi-Noori, S, Fisher, E M C, Holton, J L, Revesz, T, Rossor, M N, Collinge, J, Mead, S & Isaacs, A M 2010, ' FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration ', Acta Neuropathologica, vol. 120, no. 1, pp. 33-41 . https://doi.org/10.1007/s00401-010-0698-6
Acta Neuropathologica, 120(1), 33-41. Springer Verlag
Acta Neuropathologica, 120(1), 33-41. Springer-Verlag
Acta neuropathologica
Acta Neuropathologica
Acta Neuropathologica, 120(1), 33-41. Springer Verlag
Acta Neuropathologica, 120(1), 33-41. Springer-Verlag
Acta neuropathologica
Acta Neuropathologica
Through an international consortium, we have collected 37 tau- and TAR DNA-binding protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, and present here the first comprehensive analysis of these cases in terms of neuropatholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c545424334d583222f2b1385ef39ff
https://research.vumc.nl/ws/files/760631/261890.pdf
https://research.vumc.nl/ws/files/760631/261890.pdf
Autor:
Eric Tardif, Geneviève Leuba, André Vernay, Armand Savioz, Irène M. Riederer, Beat M. Riederer, Béatrice Carnal, Rudolf Kraftsik
Publikováno v:
Journal of Alzheimer's Disease, Vol. 15, No 1 (2008) pp. 139-151
We investigated how synaptic plasticity is related to the neurodegeneration process in the human dorsolateral prefrontal cortex. Pre- and postsynaptic proteins of Brodmann's area 9 from patients with Alzheimer's disease (AD) and age-matched controls
Autor:
Tim De Pooter, Bart Dermaut, Jean-Jacques Martin, Rosa Rademakers, Daniel Pirici, Cornelia M. van Duijn, Ilse Gijselinck, Samir Kumar-Singh, Peter Paul De Deyn, Rik Vandenberghe, Julie van der Zee, Krist'l Vennekens, Ivy Cuijt, Karin Peeters, Marleen Van den Broeck, Marc Cruts, Raphael Sciot, Sebastiaan Engelborghs, Christine Van Broeckhoven, Patrick Santens, Hans Wils, Maria Mattheijssens
Publikováno v:
Nature, 442(7105), 920-924. Nature Publishing Group
Nature
Nature
Frontotemporal dementia (FTD) with ubiquitin-immunoreactive neuronal inclusions ( both cytoplasmic and nuclear) of unknown nature has been linked to a chromosome 17q21 region (FTDU-17) containing MAPT (microtubule-associated protein tau)(1-3). FTDU-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c95075a59f215b76d714cf6c9547c0
https://pure.eur.nl/en/publications/9296e80b-72d8-47e9-a0f3-1e53ce95dd81
https://pure.eur.nl/en/publications/9296e80b-72d8-47e9-a0f3-1e53ce95dd81