3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments

Autor: Bronsard, J., Savary, C., Massart, J., Viel, R., Moutaux, L., Catheline, D., Rioux, V., Clement, B., Corlu, A., Fromenty, B., Ferron, P.J.

Publikováno v: In Toxicology in Vitro February 2024 94

Maternal and neonatal outcomes and prognostic factors in acute fatty liver of pregnancy

Autor: Joueidi, Y., Peoc’h, K., Le Lous, M., Bouzille, G., Rousseau, C., Bardou-Jacquet, E., Bendavid, C., Damaj, L., Fromenty, B., Lavoué, V., Moreau, C. ^⁎

Publikováno v: In European Journal of Obstetrics & Gynecology and Reproductive Biology September 2020 252:198-205

Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach.

Autor: Beausoleil C; French Agency for Food, Environmental and Occupational Health and Safety (Anses), 94701 Maisons-Alfort, France. Electronic address: claire.beausoleil@anses.fr., Thébault A; French Agency for Food, Environmental and Occupational Health and Safety (Anses), 94701 Maisons-Alfort, France., Andersson P; Chemistry Department, Umeå University, SE-901 87 Umeå, Sweden., Cabaton NJ; INRAE. UMR1331 Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UT3, 31027 Toulouse, France., Ermler S; Department of Life Sciences, Centre of Genome Engineering and Maintenance, College of Health, Medicine and Life Sciences, Brunel University London, UB8 3PH Uxbridge, United Kingdom., Fromenty B; INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR_A 1341, UMR_S 1317, F-35000 Rennes, France., Garoche C; Institut de Recherche en Cancérologie de Montpellier (IRCM), Inserm U1194, Université Montpellier, Institut Régional du Cancer de Montpellier (ICM), Montpellier, France., Griffin JL; The Rowett Institute, Foresterhill Health Campus, University of Aberdeen, Aberdeen, UK., Hoffmann S; Seh Consulting + Services, Stembergring 15, 33106 Paderborn, Germany., Kamstra JH; Institute for Risk Assessment Sciences, Department of Population Health Sciences, Utrecht University, Utrecht, the Netherlands., Kubickova B; Radiation, Chemical and Environmental Hazards (RCE), Department of Toxicology, UK Health Security Agency (UKHSA), Harwell Science and Innovation Campus, Chilton OX11 0RQ, Oxon, United Kingdom., Lenters V; Institute for Risk Assessment Sciences, Department of Population Health Sciences, Utrecht University, Utrecht, the Netherlands., Kos VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Poupin N; INRAE. UMR1331 Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UT3, 31027 Toulouse, France., Remy S; Flemish Institute for Technological Research (VITO), 2400 Mol, Belgium., Sapounidou M; Chemistry Department, Umeå University, SE-901 87 Umeå, Sweden., Zalko D; INRAE. UMR1331 Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UT3, 31027 Toulouse, France., Legler J; Institute for Risk Assessment Sciences, Department of Population Health Sciences, Utrecht University, Utrecht, the Netherlands., Jacobs MN; Radiation, Chemical and Environmental Hazards (RCE), Department of Toxicology, UK Health Security Agency (UKHSA), Harwell Science and Innovation Campus, Chilton OX11 0RQ, Oxon, United Kingdom., Rousselle C; French Agency for Food, Environmental and Occupational Health and Safety (Anses), 94701 Maisons-Alfort, France.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2024 Aug; Vol. 489, pp. 116995. Date of Electronic Publication: 2024 Jun 09.

Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure.

Autor: Imran M; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France.; Iqra University, Karachi, Pakistan., Chalmel F; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Sergent O; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Evrard B; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Le Mentec H; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Legrand A; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Dupont A; Univ Rennes, Biosit - UMS 3480, US_S 018, F-35000, Rennes, France., Bescher M; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Bucher S; Univ Rennes, Inserm, Inrae, Institut NUMECAN (Nutrition Metabolisms and Cancer)-UMR_S 13 1241, and UMR_A 1341, 35000, Rennes, France., Fromenty B; Univ Rennes, Inserm, Inrae, Institut NUMECAN (Nutrition Metabolisms and Cancer)-UMR_S 13 1241, and UMR_A 1341, 35000, Rennes, France., Huc L; Université de Toulouse, Inrae, ENVT, INP-Purpan, UPS, Toxalim (Research Centre in Food Toxicology), 31027, Toulouse, France., Sparfel L; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Lagadic-Gossmann D; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Podechard N; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085, F-35000, Rennes, France. norman.podechard@univ-rennes1.fr.

Publikováno v: Cell biology and toxicology [Cell Biol Toxicol] 2023 Apr; Vol. 39 (2), pp. 371-390. Date of Electronic Publication: 2022 Apr 12.

NAFLD et dysfonction mitochondriale

Autor: Roden, Dan, Fromenty, B.

Publikováno v: Médecine des Maladies Métaboliques
Médecine des Maladies Métaboliques, 2023, 17 (3), pp.241-247. ⟨10.1016/j.mmm.2023.03.006⟩

National audience; Numerous investigations have shown the presence of mitochondrial dysfunction in nonalcoholic fatty liver disease (NAFLD). While mitochondrial oxidation pathways are increased during simple steatosis, these adaptations wane during n

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https://hal.science/hal-04123855