An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation.

Autor: Casteels T; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, A-1090, Vienna, Austria., Zhang Y; State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Collaborative Innovation Center for Genetics and Development, Shanghai, 200438, China., Frogne T; Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark., Sturtzel C; Innovative Cancer Models, St. Anna Children's Cancer Research Institute, Vienna, Austria., Lardeau CH; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, A-1090, Vienna, Austria., Sen I; Integrated Cardio Metabolic Center, Karolinska Institutet, Novum, Blickagången 6, SE-141 57 Huddinge, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, Blickagången 16, SE-141 52 Huddinge, Sweden., Liu X; Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 20011, China., Hong S; State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Collaborative Innovation Center for Genetics and Development, Shanghai, 200438, China., Pauler FM; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, A-1090, Vienna, Austria., Penz T; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, A-1090, Vienna, Austria., Brandstetter M; Electron Microscopy Facility, Vienna BioCenter Core Facilities GmbH, Vienna, Austria., Barbieux C; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland., Berishvili E; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland., Heuser T; Electron Microscopy Facility, Vienna BioCenter Core Facilities GmbH, Vienna, Austria., Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, A-1090, Vienna, Austria., Riedel CG; Integrated Cardio Metabolic Center, Karolinska Institutet, Novum, Blickagången 6, SE-141 57 Huddinge, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, Blickagången 16, SE-141 52 Huddinge, Sweden., Meyer D; Institute of Molecular Biology / CMBI, Leopold-Franzens-University Innsbruck, Technikerstr. 25, 6020, Innsbruck, Austria., Distel M; Innovative Cancer Models, St. Anna Children's Cancer Research Institute, Vienna, Austria., Hecksher-Sørensen J; Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark., Li J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, A-1090, Vienna, Austria; State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Collaborative Innovation Center for Genetics and Development, Shanghai, 200438, China. Electronic address: li_jin_lifescience@fudan.edu.cn., Kubicek S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, A-1090, Vienna, Austria. Electronic address: skubicek@cemm.oeaw.ac.at.

Publikováno v: Molecular metabolism [Mol Metab] 2021 Dec; Vol. 54, pp. 101329. Date of Electronic Publication: 2021 Aug 25.

The Hippo Signaling Pathway, Reactive Oxygen Species Production, and Oxidative Stress: A Two-Way Traffic Regulation.

Autor: Amanda, Bella^1,2 (AUTHOR) bella.amanda@fk.unair.ac.id, Pragasta, Rangga^1,3 (AUTHOR) haris.cakrasana@gmail.com, Cakrasana, Haris¹ (AUTHOR) zakiyatul-f@fk.unair.ac.id, Mustika, Arifa⁴ (AUTHOR) arifa.mustika@fk.unair.ac.id, Faizah, Zakiyatul¹ (AUTHOR), Oceandy, Delvac⁵ (AUTHOR) delvac.oceandy@manchester.ac.uk

Publikováno v: Cells (2073-4409). Nov2024, Vol. 13 Issue 22, p1868. 13p.

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

Autor: Tsonkova VG; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark; University of Copenhagen, Department of Biomedical Sciences, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark., Sand FW; Novo Nordisk A/S, Diabetes Research, GLP-1 & T2D Pharmacology, Novo Nordisk Park, 2760, Maaloev, Denmark., Wolf XA; Novo Nordisk A/S, Diabetes Research, GLP-1 & T2D Pharmacology, Novo Nordisk Park, 2760, Maaloev, Denmark., Grunnet LG; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Kirstine Ringgaard A; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark; University of Copenhagen, Department of Biomedical Sciences, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark., Ingvorsen C; Novo Nordisk A/S, Diabetes Research, Histology & Imaging, Novo Nordisk Park, 2760, Maaloev, Denmark., Winkel L; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Kalisz M; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Dalgaard K; Novo Nordisk A/S, Diabetes Research, GLP-1 & T2D Pharmacology, Novo Nordisk Park, 2760, Maaloev, Denmark., Bruun C; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Fels JJ; Novo Nordisk A/S, Discovery Biology & Technology, Research Bioanalysis, Novo Nordisk Park, 2760, Maaloev, Denmark., Helgstrand C; Novo Nordisk A/S, Protein Engineering, Expression Technologies 1, Novo Nordisk Park, 2760, Maaloev, Denmark., Hastrup S; Novo Nordisk A/S, Protein Engineering, Expression Technologies 1, Novo Nordisk Park, 2760, Maaloev, Denmark., Öberg FK; Novo Nordisk A/S, Protein Engineering, Expression Technologies 1, Novo Nordisk Park, 2760, Maaloev, Denmark., Vernet E; Novo Nordisk Research Center Seattle Inc., Protein Engineering, NNRC Seattle, Inc., 530 Fairview Avenue North, 98109, Seattle, WA, USA., Sandrini MPB; Novo Nordisk A/S, Protein Engineering, Upstream Technologies, Novo Nordisk Park, 2760, Maaloev, Denmark., Shaw AC; Novo Nordisk A/S, Protein Engineering, Characterisation & Modelling Technology, Novo Nordisk Park, 2760, Maaloev, Denmark., Jessen C; Novo Nordisk A/S, Protein Engineering, Protein & Peptide Chemistry 2, Novo Nordisk Park, 2760, Maaloev, Denmark., Grønborg M; Novo Nordisk A/S, Discovery Biology & Technology, Discovery ADME, Novo Nordisk Park, 2760, Maaloev, Denmark., Hald J; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Willenbrock H; Novo Nordisk A/S, Discovery Biology & Technology, Bioinformatics, Maaloev, Denmark., Madsen D; Novo Nordisk A/S, Discovery Biology & Technology, Bioinformatics, Maaloev, Denmark., Wernersson R; Intomics A/S, Lottenborgvej 26, DK-2800, Lyngby, Denmark., Hansson L; Intomics A/S, Lottenborgvej 26, DK-2800, Lyngby, Denmark; Novo Nordisk Pharma Ltd., Research Centre Oxford, Bioinformatics, Novo Nordisk Ltd., 3 City Place Beehive Ring Road, Gatwick, RH6 0PA, West Sussex, United Kingdom., Jensen JN; Novo Nordisk Pharma Ltd., Research Centre Oxford, Bioinformatics, Novo Nordisk Ltd., 3 City Place Beehive Ring Road, Gatwick, RH6 0PA, West Sussex, United Kingdom., Plesner A; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Alanentalo T; Novo Nordisk A/S, Diabetes Research, Histology & Imaging, Novo Nordisk Park, 2760, Maaloev, Denmark., Petersen MBK; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark; University of Copenhagen, DanStem, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark., Grapin-Botton A; University of Copenhagen, DanStem, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark., Honoré C; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Ahnfelt-Rønne J; Novo Nordisk A/S, Diabetes Research, Histology & Imaging, Novo Nordisk Park, 2760, Maaloev, Denmark., Hecksher-Sørensen J; Novo Nordisk A/S, Diabetes Research, Histology & Imaging, Novo Nordisk Park, 2760, Maaloev, Denmark., Ravassard P; Institut du cerveau et de la moelle (ICM) - Hôpital Pitié-Salpêtrière, Boulevard de l'Hôpital, Sorbonne Universités, Inserm, CNRS, UPMC Univ, Paris 06, Paris, France., Madsen OD; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Rescan C; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark., Frogne T; Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark. Electronic address: tfro@novonordisk.com.

Publikováno v: Molecular metabolism [Mol Metab] 2018 Feb; Vol. 8, pp. 144-157. Date of Electronic Publication: 2017 Dec 19.

Novel Protein Biomarkers and Therapeutic Targets for Type 1 Diabetes and Its Complications: Insights from Summary-Data-Based Mendelian Randomization and Colocalization Analysis.

Autor: Zou, Mingrui^1,2 (AUTHOR) 2110301145@stu.pku.edu.cn, Yang, Jichun¹ (AUTHOR) yangj@bjmu.edu.cn

Publikováno v: Pharmaceuticals (14248247). Jun2024, Vol. 17 Issue 6, p766. 17p.

Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia.

Autor: Ye, Lusha^1,2 (AUTHOR), Gao, Yanan² (AUTHOR), Mok, Simon Wing Fai³ (AUTHOR), Liao, Wucan² (AUTHOR), Wang, Yazhou² (AUTHOR), Chen, Changjiang² (AUTHOR), Yang, Lijun¹ (AUTHOR), Zhang, Junfeng² (AUTHOR), Shi, Liyun^1,2 (AUTHOR) sly0202@zjsru.edu.cn

Publikováno v: Journal of Nanobiotechnology. 4/18/2024, Vol. 22 Issue 1, p1-20. 20p.