Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Fritz Melchers"'
Autor:
Marta Ferreira-Gomes, Yidan Chen, Pawel Durek, Hector Rincon-Arevalo, Frederik Heinrich, Laura Bauer, Franziska Szelinski, Gabriela Maria Guerra, Ana-Luisa Stefanski, Antonia Niedobitek, Annika Wiedemann, Marina Bondareva, Jacob Ritter, Katrin Lehmann, Sebastian Hardt, Christian Hipfl, Sascha Hein, Eberhard Hildt, Mareen Matz, Henrik E. Mei, Qingyu Cheng, Van Duc Dang, Mario Witkowski, Andreia C. Lino, Andrey Kruglov, Fritz Melchers, Carsten Perka, Eva V. Schrezenmeier, Andreas Hutloff, Andreas Radbruch, Thomas Dörner, Mir-Farzin Mashreghi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we de
Externí odkaz:
https://doaj.org/article/6afb3ecd327947ce81ffe2bed6522ae5
Autor:
Hiromi Kubagawa, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K. Jani, Kazuhito Honjo, Shozo Izui, Andreas Radbruch, Fritz Melchers
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
AbstractUnlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of auto
Externí odkaz:
https://doaj.org/article/5722afa10f5c4409a38943daca3eb2a0
Autor:
Peter K Jani, Georg Petkau, Yohei Kawano, Uwe Klemm, Gabriela Maria Guerra, Gitta Anne Heinz, Frederik Heinrich, Pawel Durek, Mir-Farzin Mashreghi, Fritz Melchers
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002015 (2023)
Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell lineages. This steady-state hematopoiesis from HSC and multipotent progenitors (MPPs) in BM c
Externí odkaz:
https://doaj.org/article/f5721978d1074d5487f1c9dc30066fbd
Autor:
Pedram Mahmoudi Aliabadi, Ruth Teuber, Peter K. Jani, Landon Wilson, Philipp Enghard, Stephen Barnes, Nicholas Chiorazzi, Andreas Radbruch, Fritz Melchers, Hiromi Kubagawa
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The FcR for IgM (FcµR) is the newest member of the FcR family, selectively expressed by lymphocytes, and distinct from FcRs for switched Ig isotypes that are expressed by various immune cell types and non-hematopoietic cells. From studies of Fcmr-ab
Externí odkaz:
https://doaj.org/article/6f1d02e3cf8f4a39ace658d75146e204
Autor:
Marta Ferreira-Gomes, Andrey Kruglov, Pawel Durek, Frederik Heinrich, Caroline Tizian, Gitta Anne Heinz, Anna Pascual-Reguant, Weijie Du, Ronja Mothes, Chaofan Fan, Stefan Frischbutter, Katharina Habenicht, Lisa Budzinski, Justus Ninnemann, Peter K. Jani, Gabriela Maria Guerra, Katrin Lehmann, Mareen Matz, Lennard Ostendorf, Lukas Heiberger, Hyun-Dong Chang, Sandy Bauherr, Marcus Maurer, Günther Schönrich, Martin Raftery, Tilmann Kallinich, Marcus Alexander Mall, Stefan Angermair, Sascha Treskatsch, Thomas Dörner, Victor Max Corman, Andreas Diefenbach, Hans-Dieter Volk, Sefer Elezkurtaj, Thomas H. Winkler, Jun Dong, Anja Erika Hauser, Helena Radbruch, Mario Witkowski, Fritz Melchers, Andreas Radbruch, Mir-Farzin Mashreghi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produc
Externí odkaz:
https://doaj.org/article/58a67a60b8ae4622829438abe4d63e7c
Autor:
Hiromi Kubagawa, Caren Clark, Christopher M. Skopnik, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Ruth Teuber, Peter K. Jani, Andreas Radbruch, Fritz Melchers, Niklas Engels, Jürgen Wienands
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5728 (2023)
IgM is the first antibody to emerge during phylogeny, ontogeny, and immune responses and serves as a first line of defense. Effector proteins interacting with the Fc portion of IgM, such as complement and its receptors, have been extensively studied
Externí odkaz:
https://doaj.org/article/5682210c98354bf3b7bbdae053a5c224
Autor:
Rebecca Cornelis, Stefanie Hahne, Adriano Taddeo, Georg Petkau, Darya Malko, Pawel Durek, Manja Thiem, Lukas Heiberger, Lena Peter, Elodie Mohr, Cora Klaeden, Koji Tokoyoda, Francesco Siracusa, Bimba Franziska Hoyer, Falk Hiepe, Mir-Farzin Mashreghi, Fritz Melchers, Hyun-Dong Chang, Andreas Radbruch
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107982- (2020)
Summary: The persistence of long-lived memory plasma cells in the bone marrow depends on survival factors available in the bone marrow, which are provided in niches organized by stromal cells. Using an ex vivo system in which we supply the known surv
Externí odkaz:
https://doaj.org/article/98a5523b3ebf485e83c35f6851db7f1b
Autor:
David Reismann, Jonathan Stefanowski, Robert Günther, Asylkhan Rakhymzhan, Romano Matthys, Reto Nützi, Sandra Zehentmeier, Katharina Schmidt-Bleek, Georg Petkau, Hyun-Dong Chang, Sandra Naundorf, York Winter, Fritz Melchers, Georg Duda, Anja E. Hauser, Raluca A. Niesner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Longitudinal imaging of bone marrow would shed insight into long-term cellular dynamics within this compartment. Here, the authors develop a multi-photon imaging approach for the mouse femur and reveal extensive vascular plasticity within the bone ma
Externí odkaz:
https://doaj.org/article/5461e2efd91248698ccbbea37bccb7fc
Autor:
Hiromi Kubagawa, Kazuhito Honjo, Naganari Ohkura, Shimon Sakaguchi, Andreas Radbruch, Fritz Melchers, Peter K. Jani
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
It is now evident from studies of mice unable to secrete IgM that both non-immune “natural” and antigen-induced “immune” IgM are important for protection against pathogens and for regulation of immune responses to self-antigens. Since identif
Externí odkaz:
https://doaj.org/article/c698e9fef4b7410e9a6ee008a27b89e0
Autor:
Julia Tornack, Stephen T Reece, Wolfgang M Bauer, Alexis Vogelzang, Silke Bandermann, Ulrike Zedler, Georg Stingl, Stefan H E Kaufmann, Fritz Melchers
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169119 (2017)
An estimated third of the world's population is latently infected with Mycobacterium tuberculosis (Mtb), with no clinical signs of tuberculosis (TB), but lifelong risk of reactivation to active disease. The niches of persisting bacteria during latent
Externí odkaz:
https://doaj.org/article/153fa9f26ac140558869436ab818e062