Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fritz Kramer"'
Publikováno v:
Science Technology and Engineering Journal (STEJ), Vol 8, Iss 2, Pp 1-16 (2022)
The murine cutaneous sarcoma cell line TSC2ang1 has been established in 1999 and recently been suggested to be a model for tuberous sclerosis-associated skin lesions/ hamartomas. This suggestion was founded in first place on the fact that the cell li
Externí odkaz:
https://doaj.org/article/286e04affec04694a9d7625238cfd341
Autor:
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decre
Externí odkaz:
https://doaj.org/article/b04d4dfb479846a2b8a0cd173136a2f2
Autor:
Zehua Bian, Qiang Wang, Xinyu Zhou, Tao Tan, Ki Ho Park, H. Fritz Kramer, Alan McDougal, Nicholas J. Laping, Sanjay Kumar, T. M. Ayodele Adesanya, Matthew Sermersheim, Frank Yi, Xinxin Wang, Junwei Wu, Kristyn Gumpper, Qiwei Jiang, Duofen He, Pei-Hui Lin, Haichang Li, Fangxia Guan, Jingsong Zhou, Mark J. Kohr, Chunyu Zeng, Hua Zhu, Jianjie Ma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
MG53 is a protein that regulates the cell membrane repair process, and it’s been suggested that it might play a role in diabetes. Here, the authors demonstrate that circulating MG53 functions as a myokine to facilitate tissue injury-repair and rege
Externí odkaz:
https://doaj.org/article/e6e90eddc7d9412a80c0edb861c8f4a1
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Autor:
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments.
Externí odkaz:
https://doaj.org/article/e1f73e6f4eda4a62a3d79d3777de791e
Autor:
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-1 (2018)
Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article.
Externí odkaz:
https://doaj.org/article/d03026fdb79744668aebcc8fa062fee1
Autor:
Shaymaa Azawi, Martina Rincic, Stefanie Kankel, Thomas Liehr, Milash Balachandran, Fritz Kramer
Publikováno v:
Molecular and Clinical Oncology
The murine tumor cell line LA-4 (also known as LA4 or LA 4) has been extensively used in ~70 studies from 1975 to present. However, the genetic characteristics have not been comprehensively delineated, apart from a single solid-stain cytogenetic stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b66ffe3a060fcb1d91f498a20b3c4b3
https://pubmed.ncbi.nlm.nih.gov/34881029
https://pubmed.ncbi.nlm.nih.gov/34881029
Autor:
David Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to lessen the inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21136c34e5f1b7bb25b07f869525d926
https://doi.org/10.21203/rs.3.rs-28529/v1
https://doi.org/10.21203/rs.3.rs-28529/v1
Autor:
Helen F. Sneddon, Rodolfo Cadilla, Young Do, Jeffrey Guss, Gordon Saxty, Paresh I. Masuria, Caterina Musetti, J. Darren Stuart, Beth Pietrak, Daniela Ennulat, Andrew G. King, Barry G. Shearer, Nicholas J. Kramer, Peckham Gregory, Chuck Poole, Alan R. Rendina, Daniel J. Price, H. Fritz Kramer, Tiahshun Xu, Girish Sati, Stephen A. Thomson, Patricia A. Elkins, Jason A. Holt, Alan V. McDougal, Joseph W. Wilson, Susan B. Laffan, Michael R. Jeune, Jan Klapwijk, Dean N. Thomas, Mark Youngman, Paris Ward, Paul N. Mortenson, Lisa M. Shewchuk, Eugene L. Stewart, David N. Deaton
Publikováno v:
Bioorganicmedicinal chemistry. 28(23)
GlaxoSmithKline and Astex Pharmaceuticals recently disclosed the discovery of the potent H-PGDS inhibitor GSK2894631A 1a (IC50 = 9.9 nM) as part of a fragment-based drug discovery collaboration with Astex Pharmaceuticals. This molecule exhibited good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464fe491c8ae02c9501daac98d3f990
https://pubmed.ncbi.nlm.nih.gov/33059303
https://pubmed.ncbi.nlm.nih.gov/33059303
Autor:
Young Do, Lisa A. Orband-Miller, Anthony Shillings, Joelle Le, Caterina Musetti, Gordon Saxty, Beth Pietrak, Simon Teanby Hodgson, Petrov Kimberly, Daniel J. Price, Stephen A. Thomson, Eugene L. Stewart, Christie Schulte, Ashley Paul Hancock, Terrence L. Smalley, Michael R. Jeune, H. Fritz Kramer, Chuck Poole, Heather Hobbs, Kirsten M. Kahler, J. Darren Stuart, Paul N. Mortenson, Robert T. Nolte, Jason A. Holt, David N. Deaton, Don O. Somers, Elsie Diaz, Jeffrey Guss, Robert T. Gampe, Peckham Gregory
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 47:128113
Through an internal virtual screen at GlaxoSmithKline a distinct class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors were discovered. Careful evaluation of crystal structures and SAR led to a novel, potent, and orally active imida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e5ec2ff7577c529db47e5be2c91881
https://doi.org/10.1016/j.bmcl.2021.128113
https://doi.org/10.1016/j.bmcl.2021.128113
Autor:
Qiang Wang, Alan V. McDougal, Nicholas J. Laping, Ki Ho Park, Duofen He, Jingsong Zhou, Xinyu Zhou, Matthew Sermersheim, Hua Zhu, Sanjay Kumar, Fangxia Guan, Xinxin Wang, T.M. Ayodele Adesanya, Junwei Wu, Jianjie Ma, Zehua Bian, Kristyn Gumpper, Haichang Li, Mark J. Kohr, Pei-Hui Lin, Chunyu Zeng, Frank Yi, Tao Tan, Qiwei Jiang, H. Fritz Kramer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show that MG53 present in blood circulation acts as a myokine to facilitate tissue injury-repair and regeneration. Transgenic mice with susta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686d625c2d8e8841e8e9d7d74a09a0fc
https://doi.org/10.1038/s41467-019-12483-0
https://doi.org/10.1038/s41467-019-12483-0