Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Fritz Gerhart"'
Publikováno v:
ChemInform. 22
Publikováno v:
Journal of Fluorine Chemistry. 50:243-249
A convenient methodology for the use of fluoroacetonitrile in organic synthesis is described. The method, a low-temperature flow technique, is suitable for small scale as well as for large scale applications.
Publikováno v:
Liebigs Annalen der Chemie. 1990:1-6
The synthesis of α-amino mono-, di-, and trifluoromethyl and difluoromethylene ketones and their derivatives is described. A one-pot sequence related to the Dakin-West reaction starts from amino acids and gives the corresponding fluorinated ketone a
Publikováno v:
Journal of medicinal chemistry. 33(8)
2-(4-Amino-4-carboxybutyl)aziridine-2-carboxylic acid (3) (aziridino-DAP) was identified as the product of spontaneous hydrolysis of alpha-(halomethyl)diaminopimelic acids (alpha-halomethyl-DAPs) 2a-c. Under physiological conditions, 3 is an extremel
Publikováno v:
ChemInform. 21
Publikováno v:
European Journal of Biochemistry. 176:237-242
A series of mono-and geminal difluorinated analogues of spermidine (4-azaoctane-1, 8-diamine) have been tested as potential substrates of partially purified rat hepatoma (HTC) cell or pure bovine spleen spermine synthase (EC 2.5.1.22). Substitution o
Publikováno v:
Journal of Neurochemistry. 37:1341-1344
omega-Monofluoromethyl and omega-difluoromethyl analogues of the known substrates of GABA-T, beta-alanine, gamma-aminobutyric acid, and 5-aminopentanoic acid, are time-dependent inhibitors of purified 4-aminobutyrate: 2-oxoglutarate aminotransferase
Publikováno v:
International Journal of Biochemistry. 19:843-852
1. 1. Injection of 2,2-difluoroputrescine (DFPut) into the yolk sac of chick embryos causes the formation of 6,6-difluorospermidine (6,6DFSpd) and 6,6-difluorospermine (6,6DFSpm), demonstrating that the difluoroanalogs of putrescine and spermidine ar
Publikováno v:
Biochemical Journal. 253:481-488
5-Fluoromethylornithine (5-FMOrn) is the first specific irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT) found. Single doses (greater than 10 mg/kg) of this compound inactivate OAT to a residual OAT-like activity. This activity
Publikováno v:
European Journal of Pharmacology. 90:129-132
Cold and restraint stress in rats induced gastric mucosa lesions, increased gastric mucosa histidine decarboxylase activity and elevated hypothalamic content. Cimetidine did not modify the biochemical effects induced by stress but partially protected