Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Fritz Costa"'
Autor:
Amy S. Lee, Susan E. Bates, John B. Patterson, Caryn Stiles, Frank Markland, Fritz Costa, Steven Swenson, Peter Baumeister, Bryce Ko, Dezheng Dong
Therapeutic targeting of the tumor vasculature that destroys preexisting blood vessels of the tumor and antiangiogenesis therapy capitalize on the requirement of tumor cells on an intact vascular supply for oxygen and nutrients for growth, expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb276a5ed007a8a768f2ba0d98125ac
https://doi.org/10.1158/0008-5472.c.6493880
https://doi.org/10.1158/0008-5472.c.6493880
Autor:
Amy S. Lee, Susan E. Bates, John B. Patterson, Caryn Stiles, Frank Markland, Fritz Costa, Steven Swenson, Peter Baumeister, Bryce Ko, Dezheng Dong
Supplementary Data from Vascular Targeting and Antiangiogenesis Agents Induce Drug Resistance Effector GRP78 within the Tumor Microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27cf682b88ff0f887819ba7ed130295
https://doi.org/10.1158/0008-5472.22363754.v1
https://doi.org/10.1158/0008-5472.22363754.v1
Autor:
Fritz Costa, Jason Chua, Toshiaki Shichinohe, Stephanie Schmitmeier, Nian Ling Zhu, Weijun Wang, Noriyuki Kasahara, Thomas C. Chen, Barbara A. Sosnowski, Steve Swenson
Publikováno v:
Journal of Neurosurgery. 103:1058-1066
Object. Adenovirus vector (AdV)—mediated gene delivery has been recently demonstrated in clinical trials as a novel potential treatment for malignant gliomas. Combined coxsackievirus B and adenovirus receptor (CAR) has been shown to function as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033d54eea63fa44f5995af24bfc96f23
https://doi.org/10.3171/jns.2005.103.6.1058
https://doi.org/10.3171/jns.2005.103.6.1058
Autor:
Bryce Ko, Fritz Costa, Dezheng Dong, John B. Patterson, Frank Markland, Peter Baumeister, Steven Swenson, Susan E. Bates, Caryn Stiles, Amy S. Lee
Publikováno v:
Cancer Research. 65:5785-5791
Therapeutic targeting of the tumor vasculature that destroys preexisting blood vessels of the tumor and antiangiogenesis therapy capitalize on the requirement of tumor cells on an intact vascular supply for oxygen and nutrients for growth, expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab4359182dfd4a35a4cf9066231733e
https://doi.org/10.1158/0008-5472.can-05-0754
https://doi.org/10.1158/0008-5472.can-05-0754
Publikováno v:
Pathophysiology of Haemostasis and Thrombosis. 34:177-183
Contortrostatin (CN) (Mr 13,500 Da) is a novel homodimeric disintegrin isolated from the venom of Agkistrodon contortrix contortrix (Southern Copperhead) snake and displays two RGD motifs (one on each chain), which modulate its interaction with integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d53b84134e0214912e596b5da8f0447
https://doi.org/10.1159/000092419
https://doi.org/10.1159/000092419
Autor:
William Ernst, Gary Fujii, Fritz Costa, Dongyun Yang, Radu O. Minea, Russell P. Sherwin, Stephen Swenson, Francis S. Markland
Publikováno v:
Toxin Reviews. 24:113-142
In this report we describe an effective method for delivery of a novel snake venom disintegrin, contortrostatin (CN), in an orthotopic, xenograft model of human mammary cancer in immunodeficient mice. Contortrostatin (Mr 13,500) is a homodimeric disi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f32fd49580107995481e1c81937308fd
https://doi.org/10.1081/txr-200046409
https://doi.org/10.1081/txr-200046409
Publikováno v:
Journal of Biological Chemistry. 276:21649-21655
Type VII collagen, the major component of anchoring fibrils, consists of a central collagenous triple-helical domain flanked by two noncollagenous domains, NC1 and NC2. The NC2 domain has been implicated in catalyzing the antiparallel dimer formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e68bd1d78557a47cbea24820193a45
https://doi.org/10.1074/jbc.m100180200
https://doi.org/10.1074/jbc.m100180200
Autor:
Francis S. Markland, Fritz Costa, Corey M. Helchowski, Radu O. Minea, Samuel J. Zidovetzki, Stephen Swenson
Publikováno v:
Toxins and Hemostasis ISBN: 9789048192946
Angiogenesis is a critical process in tumor and disease progression. A number of features are central to both tumor growth and development, and the recruitment and invasion of a growing vascular network supplying the tumor with nutrients and a mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25458c3cc01dee2331ccfe9e30a26405
https://doi.org/10.1007/978-90-481-9295-3_19
https://doi.org/10.1007/978-90-481-9295-3_19
Autor:
Corey M. Helchowski, Stephen Swenson, Samuel J. Zidovetzki, Radu O. Minea, Fritz Costa, Francis S. Markland
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 6, p e10929 (2010)
PLoS ONE, Vol 5, Iss 6, p e10929 (2010)
Similar to other integrin-targeting strategies, disintegrins have previously shown good efficacy in animal cancer models with favorable pharmacological attributes and translational potential. Nonetheless, these polypeptides are notoriously difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d275fc20111f30543777aab64a22953
https://pubmed.ncbi.nlm.nih.gov/20532165
https://pubmed.ncbi.nlm.nih.gov/20532165
Publikováno v:
Pathophysiology of haemostasis and thrombosis. 34(4-5)
Disintegrins are soluble peptides found in snake venom. They bind to Arg-Gly-Asp (RGD)-responsive integrins with high affinity (nM range) and block integrin function. Contortrostatin (CN), the disintegrin from southern copperhead venom, is a homodime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79560942e41ae34a0b024518a4ad203
https://pubmed.ncbi.nlm.nih.gov/16707922
https://pubmed.ncbi.nlm.nih.gov/16707922