Výsledky vyhledávání - "Frits van der Ham"

Akademický článek

A pathogenic proteolysis–resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function

Autor: Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song

Publikováno v: JCI Insight, Vol 7, Iss 17 (2022)

Huntington’s disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N

Externí odkaz: https://doaj.org/article/4386a98caf404dd9a84e53f674710b00

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Akademický článek

Profiling the secretion of soluble mediators by end stage osteoarthritis synovial tissue explants reveals a reduced responsiveness to an inflammatory trigger.

Autor: Lobke M Gierman, Benno van El, Frits van der Ham, Angela Koudijs, Reinout Stoop, Jan H Verheijen, Margreet Kloppenburg, Gerjo J V M van Osch, Vedrana Stojanovic-Susulic, Tom W J Huizinga, Anne-Marie Zuurmond

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62634 (2013)

OBJECTIVE: Evidence is accumulating that synovial tissue plays an active role in osteoarthritis (OA), however, exact understanding of its contribution is lacking. In order to further elucidate its role in the OA process, we aimed to identify the secr

Externí odkaz: https://doaj.org/article/cb24ac37455648b7995b492bcc1307e5

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A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function

Publikováno v: JCI insight. 7(17)

Huntington's disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890bc2b9ceb3800a14c6fbdae590d289
https://pubmed.ncbi.nlm.nih.gov/35943803

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I01 QRX-704, a novel antisense oligonucleotide therapy, designed to prevent hd pathology while maintaining htt function

Autor: Gerard Platenburg, Willeke M. C. van Roon-Mom, Herma Anthonijsz, Hyeongju Kim, Lodewijk J.A. Toonen, Nicholas S. Caron, Levi Buil, Michael R. Hayden, Zhana Karneva, Geert van der Horst, Frits van der Ham, Linda M. van der Graaf, Pontus Klein, Wouter Beumer, Ji-Joon Song

Publikováno v: Experimental therapeutics – preclinical.

Background QRX-704 is a novel antisense oligonucleotide-based therapeutic approach, aiming to mitigate mutant Huntingtin (mHTT) toxicity, while maintaining physiological HTT function. Proteolytic cleavage of mHTT generates toxic N-terminal fragments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5fa5570ed52547349af2c57b84d5030
https://doi.org/10.1136/jnnp-2018-ehdn.237

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Autor: Ellen Wachtel, Jeroen DeGroot, Sarit Sivan, Peter J. Roughley, Eve Tsitron, Alice Maroudas, Nico Sakkee, Frits van der Ham

Publikováno v: Biochemical Journal, 1, 399, 29-35

During aging and degeneration, many changes occur in the structure and composition of human cartilaginous tissues, which include the accumulation of the AGE (advanced glycation end-product), pentosidine, in long-lived proteins. In the present study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3074b9903ad620bd9f02f5fbb28f8c
https://doi.org/10.1042/bj20060579

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Collagen turnover in normal and degenerate human intervertebral discs as determined by the racemization of aspartic acid

Autor: Jeroen DeGroot, Sarit-Sara Sivan, Nico Sakkee, Eve Tsitron, Sally Roberts, Frits van der Ham, Ellen Wachtel, Alice Maroudas

Publikováno v: The Journal of biological chemistry. 283(14)

Knowledge of rates of protein turnover is important for a quantitative understanding of tissue synthesis and catabolism. In this work, we have used the racemization of aspartic acid as a marker for the turnover of collagen obtained from healthy and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78a342f7730b79e084bef1b21ace72c
https://pubmed.ncbi.nlm.nih.gov/18250164

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Aggrecan turnover in human intervertebral disc as determined by the racemization of aspartic acid

Autor: Sarit Sivan, Sally Roberts, Peter J. Roughley, Alice Maroudas, Jeroen DeGroot, Frits van der Ham, Eve Tsitron, Nico Sakkee, Ellen Wachtel

Publikováno v: Journal of Biological Chemistry, 19, 281, 13009-13014

We have used the racemization of aspartic acid as a marker for the "molecular age" of aggrecan components of the human intervertebral disc matrix (aggregating and non-aggregating proteoglycans as well as the different buoyant density fractions of agg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23110f6d6ef3c016413e1e21c141e783
https://pubmed.ncbi.nlm.nih.gov/16537531

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Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen cross-links

Autor: Christopher J. Hernandez, Bethany M. Baumbach, Frits van der Ham, Ruud A. Bank, A. Nico Sakkee, Jeroen DeGroot, Paul B. Hwu, Tony M. Keaveny, Simon Y. Tang

Publikováno v: Bone. 37(6)

The propensity of individual trabeculae to fracture (microfracture) may be important clinically since it could be indicative of bone fragility. Whether or not an overloaded trabecula fractures is determined in part by its structural ductility, a mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855a1d7b20d4e1af371ee5982b385138
https://pubmed.ncbi.nlm.nih.gov/16140600

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Profiling the Secretion of Soluble Mediators by End Stage Osteoarthritis Synovial Tissue Explants Reveals a Reduced Responsiveness to an Inflammatory Trigger

Autor: Gerjo J.V.M. van Osch, Benno van El, Anne-Marie Zuurmond, Reinout Stoop, Frits van der Ham, Jan H. Verheijen, Margreet Kloppenburg, A. Koudijs, Vedrana Stojanovic-Susulic, Tom W J Huizinga, Lobke Gierman

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62634 (2013)
PLoS ONE, 8(5)
PLoS ONE, 5, 8
PLoS ONE
PLoS One (print), 8(5). Public Library of Science

Objective:Evidence is accumulating that synovial tissue plays an active role in osteoarthritis (OA), however, exact understanding of its contribution is lacking. In order to further elucidate its role in the OA process, we aimed to identify the secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59312abd5d2fd4d5b7997eccf0537fa8
https://doi.org/10.1371/journal.pone.0062634

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